AiPD: Autoinhibited Protein Database

Gene name	Gsdmc2
Protein name	Gasdermin-C2
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:331063
EC number	3.1.3.36: Phosphoric monoester hydrolases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

270-441 (C-terminal gasdermin domain) SS

270-441 (C-terminal gasdermin domain)

5-232 (N-terminal gasdermin domain)

Cleavage (Interdomain cleavage by inflammatory caspases)

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q2KHK6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs579437847	246	I>T	No	Ensembl
rs586704464	247	Y>S	No	Ensembl
rs583059385	250	E>Q	No	Ensembl
rs864293245	251	L>F	No	Ensembl
rs581778296	354	L>P	No	Ensembl
rs241742155	375	Q>R	No	Ensembl
rs1134277916	387	E>A	No	Ensembl
rs252605414	407	L>V	No	Ensembl
rs1135348662	465	R>Q	No	Ensembl

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q2KHK6

		Description
EC Number	3.1.3.36	Phosphoric monoester hydrolases
Subcellular Localization	Cytoplasmic vesicle, phagosome membrane Early endosome membrane Membrane, clathrin-coated pit Cell projection, cilium, photoreceptor outer segment Cell projection, cilium Cytoplasmic vesicle Endosome Golgi apparatus, trans-Golgi network	Also found on macropinosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
phosphatidylinositol-4,5-bisphosphate binding	Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
phosphatidylinositol-4-phosphate binding	Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
phosphatidylserine binding	Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.

Name	Definition
defense response to bacterium	Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
intestinal epithelial cell development	The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure.
pyroptosis	A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P57764	GSDMD	Gasdermin-D	Homo sapiens (Human)	EV
Q96QA5	GSDMA	Gasdermin-A	Homo sapiens (Human)	SS
Q9BYG8	GSDMC	Gasdermin-C	Homo sapiens (Human)	SS
Q8TAX9	GSDMB	Gasdermin-B	Homo sapiens (Human)	EV
Q8CB12	Gsdmc3	Gasdermin-C3	Mus musculus (Mouse)	SS
Q3TR54	Gsdmc4	Gasdermin-C4	Mus musculus (Mouse)	SS
Q5Y4Y6	Gsdma3	Gasdermin-A3	Mus musculus (Mouse)	EV
Q99NB5	Gsdmc	Gasdermin-C	Mus musculus (Mouse)	SS
Q9D8T2	Gsdmd	Gasdermin-D	Mus musculus (Mouse)	SS
Q9EST1	Gsdma	Gasdermin-A	Mus musculus (Mouse)	SS
Q32M21	Gsdma2	Gasdermin-A2	Mus musculus (Mouse)	SS
P85967	Gsdmc	Gasdermin-C	Rattus norvegicus (Rat)	SS