Q28269
Gene name |
OCLN |
Protein name |
Occludin |
Names |
|
Species |
Canis lupus familiaris (Dog) (Canis familiaris) |
KEGG Pathway |
cfa:403844 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q28269
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q28269-F1 | Predicted | AlphaFoldDB |
No variants for Q28269
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q28269 | |||||
No associated diseases with Q28269
No regional properties for Q28269
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q28269 | |||
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| bicellular tight junction | An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. |
| cell leading edge | The area of a motile cell closest to the direction of movement. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cell-cell junction | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| bicellular tight junction assembly | The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. |
| positive regulation of lamellipodium assembly | Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. |
| positive regulation of microtubule polymerization | Any process that activates or increases the frequency, rate or extent of microtubule polymerization. |
| positive regulation of wound healing | Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. |
| protein localization to cell leading edge | A process in which a protein is transported to, or maintained in, a location within a cell leading edge. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSRPFESPP | PYRPDEFKPN | HYAPSNDVYG | GDMHVRPMLS | QPAYSFYPED | EILHFYKWTS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPGVIRILSM | LVIVMCIAIF | GCVASTLAWD | RGYGTGLMGG | SIGYPYGSGF | GSYGTGYGYG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FGYGYGYGGY | TDPRAAKGFL | LAMVAFCFIA | ALVIFVTSVI | RSDISRTRRY | YLTVIILSAF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGVMMFIATI | VYIMGVNPTA | QASGSLYSSQ | IYAMCNQFYA | STATGLYMDQ | YLYHYCVVDP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QEAIAIVLGF | MVIVAFALII | FFAVKTRRKM | DRYDKSNILW | DKEHIYDEQP | PNVEEWVKNV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SAGTQDMPPP | PSDYVERVDS | PMAYSSNGKV | NDKRLYPESS | YKSTPVPEVV | QELPATSPAD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DFRQPRYSSS | GHLEPPSKRA | PSKGRTGRPK | RLEQDHYETD | YTTGGESCDE | LEEDWIREYP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PITSDQQRQL | YKRNFDTGLQ | EYKSLQAELD | EINKELSRLD | KELDDYREES | EEYMAAADEY |
| 490 | 500 | 510 | 520 | ||
| NRLKQVKGSP | DYKNKRNYCK | QLKSKLSHIK | KMVGDYDRQK | T |