Q23288

PR
Gene name
spe-39 (vipar, ZC404.3)
Protein name
Spermatogenesis-defective protein 39
Names
SPE-39, VPS33B-interacting protein in polarity and apical restriction
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_ZC404.3
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

105-177 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q23288

Entry ID Method Resolution Chain Position Source
AF-Q23288-F1 Predicted AlphaFoldDB

No variants for Q23288

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q23288

No associated diseases with Q23288

No regional properties for Q23288

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q23288

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasmic vesicle
  • Early endosome
  • Recycling endosome
  • Late endosome
  • Localizes in both residual bodies and budding spermatids (PubMed:14504223)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

5 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
vacuolar protein processing Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes.
vacuolar transport The directed movement of substances into, out of or within a vacuole.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8SZ63 Golgin84 Golgin-84 Drosophila melanogaster (Fruit fly) PR
Q9QYE6 Golga5 Golgin subfamily A member 5 Mus musculus (Mouse) PR
10 20 30 40 50 60
MALRRKFTFE LPEDSYWNES DSNSSGLFDD LQSKQLQARA AVDNLFGGDE TPKPYVRPQN
70 80 90 100 110 120
PTPTPTNVPL QIDGRAAAVS DKANIRITDT SPRASGKIVD DFLNMKFAEN VNVAPVIQTA
130 140 150 160 170 180
PSVVSEASAS SLPSEAQRLD LDYNRLRQEH RKLKDQHEVL RHERFQPLTI EASIKRMLQG
190 200 210 220 230 240
HTVTLDYYRS LRDKTQLLKQ AVATYDNNTI FKIVIFLERT LKENIFCKIM DGQKSACRVY
250 260 270 280 290 300
TRHLQITGEW DKMNKFLRSI GQYQHASVIE FEATRKYKRN PDKRVPLLRT MLHGSFSIPE
310 320 330 340 350 360
MKFEARQMEA LMRNYEIQLQ MEKMDAGDKG EHFRKFPKTS SLIGLPALSS LYYSAMYHYD
370 380 390 400 410 420
DSPTSAASLP SVQTLIRFND RLATQTIVSA LTRLSRWPDI DKLLQPKTIT MTFSAAKSVF
430 440 450 460 470 480
KGKKSTSKWG VSINNHNLLT IVKRSHPSPP TDFIYRILKG ESDAQERLRL ALLFDVPEMV
490 500 510 520
IECLTQKGDR LSLASYAKSL KTNSVESFKA VAALNNPSIK WK