Q1T7C0

PR
Gene name
CENPL (RCJMB04_9b13)
Protein name
Centromere protein L
Names
CENP-L
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:426563
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1T7C0

Entry ID Method Resolution Chain Position Source
AF-Q1T7C0-F1 Predicted AlphaFoldDB

14 variants for Q1T7C0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1058327033 6 P>A No Ensembl
rs1057964718 12 E>D No Ensembl
rs735721497 85 S>N No Ensembl
rs737060159 104 Q>R No Ensembl
rs735647138 112 D>G No Ensembl
rs736907141 115 L>R No Ensembl
rs736192803 117 I>V No Ensembl
rs739558740 127 L>P No Ensembl
rs738841945 140 Q>R No Ensembl
rs740662753 181 L>F No Ensembl
rs732360626 230 V>G No Ensembl
rs737089865 231 D>E No Ensembl
rs733626024 235 A>P No Ensembl
rs312970698 344 Q>R No Ensembl

No associated diseases with Q1T7C0

No regional properties for Q1T7C0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q1T7C0

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, centromere
  • Localizes exclusively in the centromeres
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N0S6 CENPL Centromere protein L Homo sapiens (Human) PR
Q28HN9 cenpl Centromere protein L Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MAGGRPAGSA IEMEGAMRTL PSSGRPSGTG WQSRGPLFGR NYGLSPGSRL LPPRCQENAD
70 80 90 100 110 120
PQKMAFLLRK QWTLYSVSPL YKFSSADLKD YARMLGVFIA AEKQKGLAVD VDGELGIKVA
130 140 150 160 170 180
MSGLPELRGS EQDPAAVLVQ LSLRSSVSPK NSEEKLIWSG WFCCVAGDDL LENLPENFTC
190 200 210 220 230 240
LPLFLVNGAE SYTAIVGSWF QKTFDCCFRR LAISPLNLTW MAAMWTGCKV DKNTAATELL
250 260 270 280 290 300
FSVPHLPQPL DISYAIHPED AKALWDTVQK TPGEITQEEV DVFMECLYSH FHRHFKIHLS
310 320 330 340
ATKLVKVSTG IASAHCDGII KFLQSQYLIG VLMLLTELAI SQIQ