Q17QK1

PR
Gene name
RUNDC3A
Protein name
RUN domain-containing protein 3A
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:614322
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q17QK1

Entry ID Method Resolution Chain Position Source
AF-Q17QK1-F1 Predicted AlphaFoldDB

189 variants for Q17QK1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs480853288 17 K>N No EVA
rs449580013 24 V>L No EVA
rs463661252 27 E>A No EVA
rs477337322 29 R>S No EVA
rs445848319 30 N>S No EVA
rs445848319 30 N>T No EVA
rs434536384 33 T>P No EVA
rs447815743 35 C>W No EVA
rs478445446 74 K>R No EVA
rs479113663 91 Y>C No EVA
rs447747127 94 L>Q No EVA
rs467812019 112 N>T No EVA
rs876608308 115 T>P No EVA
rs479575638 126 V>G No EVA
rs447813694 127 A>E No EVA
rs461390849 133 M>K No EVA
rs481504162 136 Y>C No EVA
rs449999533 137 I>T No EVA
rs470149196 138 T>P No EVA
rs436259357 142 R>L No EVA
rs465023332 148 R>S No EVA
rs433734565 150 F>C No EVA
rs453375167 153 S>P No EVA
rs435634212 154 G>E No EVA
rs473522867 154 G>R No EVA
rs475772759 161 E>D No EVA
rs444766829 165 L>R No EVA
rs472023266 168 M>L No EVA
rs460250115 171 G>V No EVA
rs480353738 174 A>P No EVA
rs448843509 176 D>A No EVA
rs448843509 176 D>V No EVA
rs462568046 177 F>V No EVA
rs465326213 184 E>K No EVA
rs434291778 185 V>A No EVA
rs434291778 185 V>E No EVA
rs454319565 186 L>M No EVA
rs474452762 187 D>A No EVA
rs442985788 189 K>E No EVA
rs476116352 189 K>N No EVA
rs456119575 189 K>T No EVA
rs438417618 190 T>A No EVA
rs438417618 190 T>P No EVA
rs458390456 192 V>G No EVA
rs478382267 193 V>F No EVA
rs441124496 194 I>F No EVA
rs461188701 194 I>S No EVA
rs469930699 195 D>E No EVA
rs449801329 195 D>G No EVA
rs481303042 195 D>H No EVA
rs481303042 195 D>Y No EVA
rs445324221 199 Y>D No EVA
rs445324221 199 Y>N No EVA
rs465389540 201 K>N No EVA
rs433953046 203 T>A No EVA
rs459021316 212 E>V No EVA
rs479100297 214 E>A No EVA
rs479100297 214 E>G No EVA
rs467748989 216 H>N No EVA
rs436693688 217 S>N No EVA
rs450266755 218 A>D No EVA
rs470236566 220 S>N No EVA
rs432535105 224 E>D No EVA
rs452130372 225 D>H No EVA
rs472272106 226 N>H No EVA
rs434430550 226 N>T No EVA
rs454454011 227 S>P No EVA
rs443569546 229 E>A No EVA
rs463631851 230 H>P No EVA
rs470820493 232 Y>S No EVA
rs459499324 235 L>I No EVA
rs479158071 236 V>A No EVA
rs479158071 236 V>D No EVA
rs461327505 240 D>E No EVA
rs481440546 241 S>R No EVA
rs450331311 246 W>L No EVA
rs470301561 247 H>P No EVA
rs477456068 248 K>Q No EVA
rs446208113 250 E>D No EVA
rs466344723 251 Q>K No EVA
rs434495175 254 R>L No EVA
rs454585525 258 A>S No EVA
rs435433634 261 G>S No EVA
rs455532293 261 G>V No EVA
rs475374007 262 Y>H No EVA
rs437282368 263 L>P No EVA
rs457253368 264 E>A No EVA
rs470842461 265 E>G No EVA
rs439576670 266 L>M No EVA
rs460049928 267 V>A No EVA
rs460049928 267 V>G No EVA
rs473733326 268 R>G No EVA
rs442254153 269 L>P No EVA
rs442254153 269 L>R No EVA
rs462363750 277 L>R No EVA
rs482391296 278 E>K No EVA
rs450651349 279 A>V No EVA
rs457820250 281 N>T No EVA
rs477902940 283 R>L No EVA
rs446436809 285 Q>P No EVA
rs466484663 286 L>P No EVA
rs449069422 287 Q>P No EVA
rs469037570 288 L>P No EVA
rs470906059 289 E>D No EVA
rs457316836 289 E>G No EVA
rs437742484 289 E>K No EVA
rs433229664 290 E>* No EVA
rs453293779 290 E>A No EVA
rs453293779 290 E>G No EVA
rs433229664 290 E>Q No EVA
rs473356141 300 R>P No EVA
rs442333182 301 E>G No EVA
rs456012225 304 G>V No EVA
rs458277207 311 E>G No EVA
rs440229268 312 Q>H No EVA
rs474137057 317 I>V No EVA
rs456194951 318 P>L No EVA
rs476276147 321 H>D No EVA
rs458897457 330 D>E No EVA
rs472166080 331 L>R No EVA
rs440823940 337 N>K No EVA
rs449466043 351 A>P No EVA
rs483248943 353 N>K No EVA
rs463160964 353 N>T No EVA
rs445484751 354 P>R No EVA
rs433954782 355 K>Q No EVA
rs447676526 355 K>R No EVA
rs447676526 355 K>T No EVA
rs436465896 357 Y>C No EVA
rs467672696 357 Y>H No EVA
rs436465896 357 Y>S No EVA
rs456129901 358 R>G No EVA
rs385436842 358 R>Q No EVA
rs432197495 359 R>G No EVA
rs461520197 366 E>D No EVA
rs450023107 378 S>T No EVA
rs470082882 381 L>P No EVA
rs477553882 383 E>D No EVA
rs465981037 391 W>C No EVA
rs434625696 393 P>A No EVA
rs468504444 394 I>M No EVA
rs448378923 394 I>S No EVA
rs475922833 397 D>G No EVA
rs444185515 398 P>R No EVA
rs440290699 401 S>P No EVA
rs480003385 402 M>I No EVA
rs460315722 402 M>K No EVA
rs448823671 403 L>P No EVA
rs462452834 404 G>V No EVA
rs482799578 405 L>F No EVA
rs451032744 405 L>P No EVA
rs433410832 406 C>F No EVA
rs464726177 406 C>G No EVA
rs464726177 406 C>R No EVA
rs447159621 407 G>C No EVA
rs467298089 408 S>A No EVA
rs467298089 408 S>P No EVA
rs435553219 409 L>M No EVA
rs455744590 409 L>P No EVA
rs455744590 409 L>R No EVA
rs475859678 410 A>G No EVA
rs438090060 411 S>A No EVA
rs438090060 411 S>P No EVA
rs451826050 411 S>Y No EVA
rs471563843 412 I>L No EVA
rs460254833 414 S>R No EVA
rs473923807 415 C>R No EVA
rs462391438 416 K>N No EVA
rs442340408 416 K>T No EVA
rs482721340 417 S>C No EVA
rs444886459 420 S>C No EVA
rs458684961 420 S>N No EVA
rs447090250 421 F>L No EVA
rs478430002 421 F>V No EVA
rs467232729 422 K>I No EVA
rs435885132 423 S>Y No EVA
rs449255630 425 E>* No EVA
rs469355201 425 E>D No EVA
rs438029484 426 C>G No EVA
rs471944005 430 D>N No EVA
rs433724317 431 S>G No EVA
rs473860407 433 E>G No EVA
rs476191230 435 S>N No EVA
rs462728717 435 S>R No EVA
rs438414232 437 A>G No EVA
rs478770994 439 S>G No EVA
rs440600018 439 S>I No EVA
rs460743236 441 S>R No EVA
rs449593510 442 S>W No EVA

No associated diseases with Q17QK1

2 regional properties for Q17QK1

Type Name Position InterPro Accession
domain RUN domain 52 - 184 IPR004012
domain RUN domain-containing protein 3A, RUN domain 30 - 180 IPR047338

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
positive regulation of cGMP-mediated signaling Any process that increases the rate, frequency or extent of cGMP-mediated signaling.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q08E29 RUNDC3B RUN domain-containing protein 3B Bos taurus (Bovine) PR
Q59EK9 RUNDC3A RUN domain-containing protein 3A Homo sapiens (Human) PR
Q6PDC0 Rundc3b RUN domain-containing protein 3B Mus musculus (Mouse) PR
O08576 Rundc3a RUN domain-containing protein 3A Mus musculus (Mouse) PR
Q0V9V7 rundc3a RUN domain-containing protein 3A Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MEASFVQTTM ALGLSSKKAS SRNVAVERRN LITVCRFSVK TLLEKYTTEP IDDSSEEFVN
70 80 90 100 110 120
FAAILEQILS HRFKGPVSWF SSDGQRGFWD YIRLACSKVP NNCVSSIENM ENISTARAKG
130 140 150 160 170 180
RAWIRVALME KRMSEYITTA LRDTRTTRRF YDSGAIMMRE EATVLTGMLI GLSAIDFSFC
190 200 210 220 230 240
LKGEVLDGKT PVVIDYTPYL KFTQSYDYLT DEEERHSAES STSEDNSPEH PYLPLVTDED
250 260 270 280 290 300
SWYSKWHKME QKFRIVYAQK GYLEELVRLR ESQLKDLEAE NRRLQLQLEE AAAQNQREKR
310 320 330 340 350 360
ELEGVILELQ EQLTGLIPGD HAPLAQGSKD LTTRLVNQWP SLGTLSGAEG ANNPKLYRRH
370 380 390 400 410 420
SFMSTEPLSA EASLSSDSQR LGEGKRDEEP WGPIGKDPTP SMLGLCGSLA SIPSCKSLAS
430 440
FKSNECLVSD SPEGSPALSP S