O08576
Gene name |
Rundc3a (Rap2ip, Rpip8) |
Protein name |
RUN domain-containing protein 3A |
Names |
Rap2-interacting protein 8, RPIP-8 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:51799 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O08576
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O08576-F1 | Predicted | AlphaFoldDB |
17 variants for O08576
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389141362 | 6 | V>A | No | EVA | |
| rs3389207559 | 7 | Q>R | No | EVA | |
| rs3389216976 | 14 | L>V | No | EVA | |
| rs3389207552 | 18 | K>* | No | EVA | |
| rs3389194525 | 63 | A>G | No | EVA | |
| rs3389214128 | 77 | A>T | No | EVA | |
| rs3389199972 | 108 | C>S | No | EVA | |
| rs3389207526 | 131 | V>M | No | EVA | |
| rs3389221362 | 132 | A>V | No | EVA | |
| rs3389207570 | 134 | M>L | No | EVA | |
| rs3389216910 | 300 | N>H | No | EVA | |
| rs3389199949 | 302 | R>G | No | EVA | |
| rs3389194554 | 304 | K>M | No | EVA | |
| rs3389199993 | 313 | E>D | No | EVA | |
| rs3389204681 | 314 | L>Q | No | EVA | |
| rs3402834232 | 380 | S>T | No | EVA | |
| rs3402693184 | 381 | S>T | No | EVA |
No associated diseases with O08576
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of cGMP-mediated signaling | Any process that increases the rate, frequency or extent of cGMP-mediated signaling. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q08E29 | RUNDC3B | RUN domain-containing protein 3B | Bos taurus (Bovine) | PR |
| Q17QK1 | RUNDC3A | RUN domain-containing protein 3A | Bos taurus (Bovine) | PR |
| Q59EK9 | RUNDC3A | RUN domain-containing protein 3A | Homo sapiens (Human) | PR |
| Q6PDC0 | Rundc3b | RUN domain-containing protein 3B | Mus musculus (Mouse) | PR |
| Q0V9V7 | rundc3a | RUN domain-containing protein 3A | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEASFVQTTM | ALGLPSKKAS | SRNVIVERRN | LITVCRFSVK | TLLEKYTAEP | IDDSSEEFVN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FAAILEQILS | HRFKACAPAG | PASWFSSDGQ | RGFWDYIRLA | CSKVPNNCVS | SIENMENIST |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ARAKGRAWIR | VALMEKRMSE | YITTALRDNR | TTRRFYDSGA | IMLREEATVL | TGMLIGLSAI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DFSFCLKGEV | LDGKTPVVID | YTPYLKFTQS | YDYLTDEEER | HSAESSTSED | NSPEHPYLPL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VTDEDSWYNK | WHKMEQKFRI | VYAQKGYLEE | LVRLRESQLK | DLEAENRRLQ | LQLEEAAAQN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QREKRELEGV | ILELQEQLTG | LIPGDHAPLA | QGSKELTTSL | VNQWPSLSTL | HRPEGASNSK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LYRRHSFMST | EPLSAEASLS | SDSQRLGEAK | RDEEPWGPIG | KDPTPSMLGL | CGSLASIPSC |
| 430 | 440 | ||||
| KSLASFKSNE | CLVSDSPEGS | PALSPS |