AiPD: Autoinhibited Protein Database

Q16186

Gene name	ADRM1 (GP110)
Protein name	Proteasomal ubiquitin receptor ADRM1
Names	110 kDa cell membrane glycoprotein, Gp110, Adhesion-regulating molecule 1, ARM-1, Proteasome regulatory particle non-ATPase 13, hRpn13, Rpn13 homolog
Species	Homo sapiens (Human)
KEGG Pathway	hsa:11047
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

178-250 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

178-250 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

19 structures for Q16186

Entry ID	Method	Resolution	Chain	Position	Source
2KQZ	NMR	-	A	253-407	PDB
2KR0	NMR	-	A	1-407	PDB
2L5V	NMR	-	A	260-407	PDB
2MKZ	NMR	-	A	270-407	PDB
2NBV	NMR	-	A	1-150	PDB
4UEL	X-ray	230 A	C	266-388	PDB
4UEM	X-ray	282 A	B	266-388	PDB
4WLQ	X-ray	285 A	B	286-384	PDB
4WLR	X-ray	200 A	B	285-386	PDB
5IRS	X-ray	180 A	A	2-150	PDB
5V1Y	X-ray	142 A	A/B	19-132	PDB
5V1Z	X-ray	200 A	A/B	19-132	PDB
5YMY	NMR	-	C	1-150	PDB
6CO4	NMR	-	A	1-150	PDB
6OI4	X-ray	176 A	A/B	20-132	PDB
6UYI	NMR	-	A	1-150	PDB
6UYJ	NMR	-	A	1-150	PDB
7KXI	NMR	-	A	1-150	PDB
AF-Q16186-F1	Predicted				AlphaFoldDB

321 variants for Q16186

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
COSM1179094 RCV000149189 CA174535 rs193921052	218	P>Q	Malignant tumor of prostate prostate [ClinVar, Cosmic]	Yes	ClinGen cosmic curated ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1433148831 CA409526289	3	T>I		No	ClinGen TOPMed gnomAD
CA9938889 rs748129088	7	L>P		No	ClinGen ExAC gnomAD
rs779163179 CA9938891	9	P>A		No	ClinGen ExAC gnomAD
rs745995688 CA409526330	10	S>I		No	ClinGen ExAC TOPMed gnomAD
rs745995688 CA9938892	10	S>N		No	ClinGen ExAC TOPMed gnomAD
CA9938894 rs775922708	12	V>A		No	ClinGen ExAC TOPMed gnomAD
rs376432621 CA9938893	12	V>L		No	ClinGen ESP ExAC gnomAD
CA9938895 rs760882891	13	P>A		No	ClinGen ExAC TOPMed gnomAD
CA317216881 rs760882891	13	P>S		No	ClinGen ExAC TOPMed gnomAD
CA9938897 rs776958178	14	G>D		No	ClinGen ExAC gnomAD
CA409526353 rs1396753568	15	S>P		No	ClinGen gnomAD
CA317216901 rs989027684	16	R>Q		No	ClinGen gnomAD
rs762417497 CA9938898	18	A>T		No	ClinGen ExAC gnomAD
TCGA novel	19	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373700307 CA9938899	20	N>D		No	ClinGen ESP ExAC gnomAD
rs11544169 CA9938900	20	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1568867112 CA409526392	22	Y>N		No	ClinGen Ensembl
rs1306284727 CA409526405	23	L>F		No	ClinGen gnomAD
rs1287233103 CA409526440	29	G>R		No	ClinGen gnomAD
CA409526451 rs1189701918	30	K>R		No	ClinGen Ensembl
CA9938903 rs751228802	32	S>F		No	ClinGen ExAC gnomAD
CA317216930 rs754671282	33	L>V		No	ClinGen ExAC gnomAD
CA409526480 rs1213835915	35	G>R		No	ClinGen gnomAD
CA409526507 rs1437796350	39	T>I		No	ClinGen gnomAD
CA9938908 rs777917151	40	P>A		No	ClinGen ExAC TOPMed gnomAD
rs777917151 CA9938909	40	P>S		No	ClinGen ExAC TOPMed gnomAD
CA317216961 rs1045759176	47	V>L		No	ClinGen TOPMed
rs780084719 CA9938911	49	I>V		No	ClinGen ExAC gnomAD
TCGA novel	50	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1411180422 CA409526589	50	Q>E		No	ClinGen TOPMed
CA9938913 rs369612978	52	T>M		No	ClinGen ESP ExAC
RCV000896064 CA9938914 rs115562292	53	D>E		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
COSM1632387 CA9938916 rs770269675	56	L>F	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs922386747 CA317217042	60	C>Y		No	ClinGen Ensembl
CA409526743 rs1568867381	63	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1446754521 CA409526751	63	D>V		No	ClinGen gnomAD
rs765886959 CA9938919	64	R>K		No	ClinGen ExAC gnomAD
CA409526772 rs1475080316	65	T>M		No	ClinGen TOPMed
CA9938921 rs759262763	68	N>K		No	ClinGen ExAC TOPMed gnomAD
rs767113789 CA9938922	69	V>L		No	ClinGen ExAC gnomAD
CA9938960 rs760438229	72	D>E		No	ClinGen ExAC TOPMed gnomAD
CA409527659 rs1187308173	77	P>S		No	ClinGen TOPMed gnomAD
rs998425225 CA317218236	84	R>P		No	ClinGen TOPMed
CA409527810 rs998425225	84	R>Q		No	ClinGen TOPMed
rs1431472743 CA409527802	84	R>W		No	ClinGen gnomAD
CA409527850 rs1396149314	86	P>L		No	ClinGen gnomAD
CA9938962 rs761574396	88	C>R		No	ClinGen ExAC gnomAD
CA409527902 rs1360250730	89	P>R		No	ClinGen gnomAD
rs765212539 CA9938963	89	P>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	93	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750328793 CA9938964	94	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs543759050 CA409528043	99	K>E		No	ClinGen gnomAD
rs543759050 CA317218284	99	K>Q		No	ClinGen gnomAD
CA409528120 rs1306870770	106	F>L		No	ClinGen gnomAD
rs750843932 CA9938992	112	P>S		No	ClinGen ExAC TOPMed gnomAD
CA9938993 rs758813628	113	K>R		No	ClinGen ExAC gnomAD
rs780767547 CA9938994	114	T>P		No	ClinGen ExAC gnomAD
rs202092326 CA9938995	115	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1202099270 CA409529179	119	E>D		No	ClinGen gnomAD
CA409529163 rs1462499483	119	E>Q		No	ClinGen gnomAD
rs539577971 CA9938996	120	H>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9938997 rs780931363	122	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA317220525 rs373713350	122	R>W		No	ClinGen ESP gnomAD
rs769591009 CA9938999	123	K>E		No	ClinGen ExAC gnomAD
rs201000756 CA317220553	124	V>I		No	ClinGen 1000Genomes
rs1179427338 CA409529307	126	E>D		No	ClinGen TOPMed
rs1216810393 CA409529366	130	N>D		No	ClinGen gnomAD
CA9939003 rs774277993	131	P>S		No	ClinGen ExAC gnomAD
CA9939004 rs774277993	131	P>T		No	ClinGen ExAC gnomAD
rs145275540 CA9939005	132	P>L		No	ClinGen ESP ExAC gnomAD
COSM478368 rs145275540 CA9939006	132	P>Q	kidney [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA317220606 rs1057259916	133	M>I		No	ClinGen TOPMed
rs200439129 CA317220600	133	M>T		No	ClinGen 1000Genomes TOPMed
rs1483106467 CA409529433	134	P>S		No	ClinGen TOPMed gnomAD
rs1483106467 CA409529435	134	P>T		No	ClinGen TOPMed gnomAD
rs1245018179 CA409529466	135	G>A		No	ClinGen TOPMed
CA409529495 rs1475975195	137	L>P		No	ClinGen gnomAD
rs1311018782 CA409529528	139	A>V		No	ClinGen TOPMed
TCGA novel	141	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409529570 rs1410512783	141	G>R		No	ClinGen gnomAD
rs1568871313 CA409529586	142	S>N		No	ClinGen Ensembl
CA409529618 rs1413865761	144	G>D		No	ClinGen gnomAD
CA9939012 rs752123074	144	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1357677542 CA409529646	146	E>G		No	ClinGen gnomAD
CA409529658 rs1269730034	147	L>F		No	ClinGen gnomAD
CA9939016 rs369505590	149	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs369505590 CA9939017	149	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA317220699 rs1018968857	150	L>P		No	ClinGen Ensembl
CA409529969 rs1364854465	152	G>D		No	ClinGen TOPMed
rs1418758071 CA409529756	152	G>S		No	ClinGen TOPMed
rs1568872209 CA409529991	153	E>D		No	ClinGen Ensembl
rs1371372995 CA409530003	154	G>S		No	ClinGen gnomAD
CA409530026 rs1461942314	155	G>A		No	ClinGen TOPMed gnomAD
CA409530023 rs1461942314	155	G>D		No	ClinGen TOPMed gnomAD
rs1568872257 CA409530087	158	S>G		No	ClinGen Ensembl
rs775820410 CA9939073	158	S>R		No	ClinGen ExAC gnomAD
rs887887586 CA317221325	158	S>T		No	ClinGen TOPMed gnomAD
CA9939074 rs140415181	163	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA317221339 rs1041429242	166	S>R		No	ClinGen TOPMed
CA409530262 rs1312643241	166	S>T		No	ClinGen gnomAD
rs1414989583 CA409530326	169	M>I		No	ClinGen gnomAD
rs1354505250 CA409530324	169	M>T		No	ClinGen TOPMed gnomAD
TCGA novel	169	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9939076 rs753336958	172	I>V		No	ClinGen ExAC gnomAD
CA317221372 rs867737023	173	G>E		No	ClinGen Ensembl
rs764807664 CA9939078	173	G>R		No	ClinGen ExAC gnomAD
CA9939080 rs758075935	174	P>R		No	ClinGen ExAC
CA409530389 rs1208533507	174	P>T		No	ClinGen gnomAD
CA9939082 rs751349690	176	G>S		No	ClinGen ExAC TOPMed gnomAD
CA409530416 rs1259782524	177	L>F		No	ClinGen TOPMed gnomAD
CA409530427 rs1375349899	178	G>E		No	ClinGen gnomAD
rs1194534286 CA409530423	178	G>R		No	ClinGen gnomAD
CA409530548 rs1334583060	182	G>A		No	ClinGen gnomAD
CA409530558 rs1159315719	184	G>E		No	ClinGen gnomAD
rs1459364101 CA409530562	185	A>P		No	ClinGen gnomAD
CA9939117 rs766049673	187	T>P		No	ClinGen ExAC gnomAD
CA409530585 rs1395214693	189	P>S		No	ClinGen TOPMed gnomAD
rs867947871 CA317222364	190	G>D		No	ClinGen Ensembl
CA409530597 rs1296291061	191	L>P		No	ClinGen gnomAD
rs1455121781 CA409530603	192	A>G		No	ClinGen TOPMed
CA409530600 rs1157808760	192	A>S		No	ClinGen TOPMed
rs1240521993 CA409530613	194	L>I		No	ClinGen gnomAD
CA409530625 rs1392217594	196	G>R		No	ClinGen gnomAD
CA409530632 rs1200847177	197	S>G		No	ClinGen TOPMed
TCGA novel	199	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA409530655 rs1232809136	200	P>S		No	ClinGen gnomAD
CA9939121 rs372346185	201	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	201	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9939123 rs760667216	204	S>T		No	ClinGen ExAC
CA317222429 rs916016683	205	S>A		No	ClinGen TOPMed
CA409530687 rs764186844	205	S>C		No	ClinGen ExAC TOPMed gnomAD
CA9939124 rs764186844	205	S>F		No	ClinGen ExAC TOPMed gnomAD
CA409530685 rs916016683	205	S>T		No	ClinGen TOPMed
CA409530694 rs1251127224	206	S>F		No	ClinGen gnomAD
CA9939127 rs780267914	207	S>Y		No	ClinGen ExAC
rs757693325 CA9939169	209	S>A		No	ClinGen ExAC gnomAD
CA409530723 rs1221693822	209	S>F		No	ClinGen gnomAD
rs1329189722 CA409530728	210	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1568874765 CA409530725	210	R>W		No	ClinGen Ensembl
rs1210517407 CA409530732	211	S>N		No	ClinGen gnomAD
rs1467975337 CA409530749	213	S>L		No	ClinGen TOPMed gnomAD
rs1248219132 CA409530761	215	A>G		No	ClinGen TOPMed gnomAD
CA409530762 rs1248219132	215	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	217	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9939174 rs193921052	218	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9939173 rs779806679 COSM3405252	218	P>S	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1020715949 CA317222795	219	S>P		No	ClinGen Ensembl
CA9939177 rs748030738	221	T>I		No	ClinGen ExAC gnomAD
rs1601245516 CA409530843	224	S>Y		No	ClinGen Ensembl
rs773135558 CA9939179	225	T>I		No	ClinGen ExAC gnomAD
CA409530849 rs1601245539	225	T>P		No	ClinGen Ensembl
rs759552189 CA9939180	226	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9939181 rs549209843	226	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1350583901 CA409530890	228	T>I		No	ClinGen gnomAD
rs1278521592 CA409530879	228	T>P		No	ClinGen gnomAD
CA9939183 rs760776842	229	P>A		No	ClinGen ExAC TOPMed gnomAD
CA9939184 rs750525006	229	P>L		No	ClinGen ExAC TOPMed gnomAD
CA409530897 rs760776842	229	P>S		No	ClinGen ExAC TOPMed gnomAD
rs754150150 CA9939186	230	A>S		No	ClinGen ExAC TOPMed gnomAD
rs754150150 CA9939185	230	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1435798905 CA409530920	231	P>A		No	ClinGen TOPMed gnomAD
CA9939188 rs373938952	231	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1435798905 CA409530921	231	P>S		No	ClinGen TOPMed gnomAD
CA9939189 rs757944540	232	S>F		No	ClinGen ExAC gnomAD
CA9939190 rs779683817	233	A>S		No	ClinGen ExAC gnomAD
rs1417221683 CA409530981	235	A>V		No	ClinGen gnomAD
CA9939192 rs754569348	236	A>T		No	ClinGen ExAC gnomAD
rs1394788418 CA409530992	236	A>V		No	ClinGen gnomAD
CA409531023 rs1329962436	239	A>E		No	ClinGen gnomAD
rs780960999 CA9939193	239	A>T		No	ClinGen ExAC gnomAD
rs79836754 CA9939194	240	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs79836754 CA9939195	240	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9939196 rs777637589	241	S>I		No	ClinGen ExAC TOPMed gnomAD
rs749253001 CA9939197	241	S>R		No	ClinGen ExAC TOPMed gnomAD
CA317222952 rs768360669	242	P>L		No	ClinGen TOPMed gnomAD
rs768360669 CA409531056	242	P>R		No	ClinGen TOPMed gnomAD
rs770895009 CA9939198	244	P>S		No	ClinGen ExAC TOPMed gnomAD
rs200789814 CA409531096	245	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA409531099 rs200789814	245	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA409531092 rs780652179	245	A>P		No	ClinGen ExAC TOPMed gnomAD
CA409531094 rs780652179	245	A>S		No	ClinGen ExAC TOPMed gnomAD
CA9939202 rs780652179	245	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9939203 rs200789814	245	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA409531136 rs1424400920	248	S>C		No	ClinGen gnomAD
CA409531138 rs1424400920	248	S>F		No	ClinGen gnomAD
rs1179998636 CA409531131	248	S>P		No	ClinGen TOPMed
rs1278981993 CA409531148	249	G>E		No	ClinGen gnomAD
rs767047144 CA9939207	249	G>R		No	ClinGen ExAC gnomAD
rs1267845800 CA409531182	252	A>T		No	ClinGen TOPMed
CA409531214 rs553787199	254	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA409531207 rs1568875551	254	T>P		No	ClinGen Ensembl
CA9939208 rs553787199	254	T>R		No	ClinGen 1000Genomes ExAC gnomAD
CA409531226 rs1372746753	255	A>G		No	ClinGen gnomAD
rs1487315561 CA409531218	255	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA409531236 rs1310629147	256	A>D		No	ClinGen gnomAD
CA409531230 rs1431286902	256	A>T		No	ClinGen gnomAD
COSM1182114 CA409531239 rs1310629147	256	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1051852 CA317223011	257	S>R		No	ClinGen Ensembl
rs780649427 CA9939210	258	P>L		No	ClinGen ExAC TOPMed gnomAD
rs780649427 CA409531263	258	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1568875657 CA409531259	258	P>S		No	ClinGen Ensembl
rs1327929989 CA409531286	260	Q>P		No	ClinGen TOPMed
CA409531325 rs1298087737	266	D>H		No	ClinGen gnomAD
rs1298087737 CA409531324	266	D>N		No	ClinGen gnomAD
CA409531359 rs1434986703	270	I>S		No	ClinGen TOPMed gnomAD
rs1202290473 CA409531368 COSM1412913	272	A>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs747004020 CA9939217	273	T>A		No	ClinGen ExAC gnomAD
CA9939218 rs554858154	273	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs747004020 CA409531372	273	T>P		No	ClinGen ExAC gnomAD
rs770193637 CA9939221	275	N>K		No	ClinGen ExAC TOPMed gnomAD
CA9939222 rs773702693 COSM1735020	276	V>I	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs773702693 CA9939223	276	V>L		No	ClinGen ExAC gnomAD
CA9939227 rs543223102	279	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9939226 rs758918944	279	G>R		No	ClinGen ExAC gnomAD
rs752190888 CA9939228	280	P>L		No	ClinGen ExAC TOPMed gnomAD
rs755742431 CA9939229	281	A>P		No	ClinGen ExAC gnomAD
CA409531445 rs1434318551	282	G>D		No	ClinGen TOPMed gnomAD
CA9939230 rs777460073	283	G>S		No	ClinGen ExAC gnomAD
rs556646029 CA9939231	285	Q>P		No	ClinGen 1000Genomes ExAC gnomAD
rs1464135850 CA409531495	286	V>M		No	ClinGen TOPMed
rs1017305743 CA317223561	287	D>G		No	ClinGen Ensembl
CA409531549 rs1206986513	288	L>P		No	ClinGen TOPMed
CA409531546 rs962389032	288	L>V		No	ClinGen gnomAD
CA317223564 rs867251368	289	A>T		No	ClinGen gnomAD
rs1482537395 CA409531556	290	S>G		No	ClinGen gnomAD
rs775875114 CA9939265	291	V>M		No	ClinGen ExAC gnomAD
rs760128444 CA9939266	293	T>M		No	ClinGen ExAC gnomAD
CA9939268 rs776156417	294	P>L		No	ClinGen ExAC TOPMed gnomAD
CA9939270 rs764851760	295	E>D		No	ClinGen ExAC TOPMed gnomAD
CA409531596 rs1425458203	296	I>M		No	ClinGen gnomAD
CA409531619 rs1601248738	300	I>L		No	ClinGen Ensembl
TCGA novel	300	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9939273 rs766285528	302	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1447464785 CA409531640	303	N>S		No	ClinGen TOPMed gnomAD
rs777970682 CA409531645	304	A>P		No	ClinGen ExAC TOPMed gnomAD
CA9939276 rs777970682	304	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9939277 rs199629793	304	A>V		No	ClinGen ExAC TOPMed gnomAD
rs746185311 CA9939280	309	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9939281 rs373828612	309	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1276408682 CA409531690	311	L>H		No	ClinGen gnomAD
CA409531695 rs1440336672	312	P>S		No	ClinGen gnomAD
rs747481677 CA9939283	315	P>S		No	ClinGen ExAC gnomAD
CA9939285 rs202035396	317	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA9939287 rs578081411	319	S>L		No	ClinGen 1000Genomes ExAC gnomAD
rs766122680 CA9939290	321	P>L		No	ClinGen ExAC TOPMed gnomAD
rs767621828 CA9939293	324	A>T		No	ClinGen ExAC TOPMed gnomAD
RCV000973054 CA9939294 rs45576934	324	A>V		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs77432560 CA9939299	327	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1342506230 CA409531854	328	Q>E		No	ClinGen gnomAD
rs747428161 CA9939300	329	N>D		No	ClinGen ExAC gnomAD
CA409531873 rs1313369968	329	N>K		No	ClinGen gnomAD
rs769143088 CA9939301	329	N>S		No	ClinGen ExAC gnomAD
CA409531876 rs1601249240	330	T>P		No	ClinGen Ensembl
CA9939303 rs747640477	333	S>L		No	ClinGen ExAC TOPMed gnomAD
CA409531935 rs1432175744 CA409531934	335	Q>H		No	ClinGen TOPMed
CA317224125 rs887221021	339	A>T		No	ClinGen Ensembl
CA409531979 rs1252628071	340	L>V		No	ClinGen gnomAD
CA9939337 rs764148509	341	G>D		No	ClinGen ExAC gnomAD
CA409531992 rs935122651	342	M>R		No	ClinGen TOPMed gnomAD
rs935122651 CA317224141	342	M>T		No	ClinGen TOPMed gnomAD
rs1229615771 CA409532005	344	S>G		No	ClinGen TOPMed
CA9939339 rs150640020	345	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA9939340 rs766527585	348	A>S		No	ClinGen ExAC gnomAD
CA409532040 rs1388658117 COSM1196110	349	S>L	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs767840220 CA9939343	351	Q>H		No	ClinGen ExAC gnomAD
CA409532051 rs1568878268	351	Q>R		No	ClinGen Ensembl
CA409532063 rs1411195284	353	G>A		No	ClinGen gnomAD
rs1331585347 CA409532067	354	P>S		No	ClinGen TOPMed gnomAD
rs1339851200 CA409532073	355	L>F		No	ClinGen TOPMed gnomAD
rs1339851200 CA409532071	355	L>I		No	ClinGen TOPMed gnomAD
rs1339851200 CA409532072	355	L>V		No	ClinGen TOPMed gnomAD
rs753158224 CA9939344	357	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs765985268 CA9939346	360	G>S		No	ClinGen ExAC gnomAD
rs867704098 CA317224196	363	A>V		No	ClinGen TOPMed gnomAD
rs11544168 CA317224212	365	A>P		No	ClinGen Ensembl
rs1411056631 CA409532143	366	V>M		No	ClinGen TOPMed
CA317224219 rs200235059	367	E>G		No	ClinGen Ensembl
rs1601251463 CA409532160	368	A>G		No	ClinGen Ensembl
CA409532167 rs1568878452	369	A>V		No	ClinGen Ensembl
CA9939348 rs756841363	370	N>D		No	ClinGen ExAC TOPMed gnomAD
CA409532172 rs1246580116	370	N>K		No	ClinGen TOPMed gnomAD
rs1131931 CA317224274	370	N>S		No	ClinGen gnomAD
TCGA novel	371	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1449303182 CA409532180	371	K>N		No	ClinGen gnomAD
rs764430564 CA317224284	373	D>N		No	ClinGen TOPMed
rs754055148 CA317224731	376	A>V		No	ClinGen Ensembl
CA9939384 rs775795054	379	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	379	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1391787046 CA409532250	380	A>V		No	ClinGen gnomAD
CA9939385 rs200530119	382	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA409532266 rs1306290701	382	Q>H		No	ClinGen gnomAD
rs1201045538 CA409532269	383	N>D		No	ClinGen gnomAD
CA317224738 rs1009512987	383	N>K		No	ClinGen Ensembl
CA409532272 rs1349872922	383	N>S		No	ClinGen gnomAD
rs764487645 CA9939386	384	N>D		No	ClinGen ExAC gnomAD
rs762394622 CA9939388	385	A>T		No	ClinGen ExAC TOPMed gnomAD
CA9939391 rs749882447	387	P>A		No	ClinGen ExAC gnomAD
rs749882447 CA9939390	387	P>S		No	ClinGen ExAC gnomAD
rs373954705 CA9939393	388	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9939394 rs373954705	388	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs73916515 CA9939395	390	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs769721912 CA9939397	391	E>A		No	ClinGen ExAC gnomAD
CA9939396 rs747996969	391	E>K		No	ClinGen ExAC gnomAD
CA317224867 rs561922905	392	G>D		No	ClinGen TOPMed gnomAD
CA9939399 rs370417009	392	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9939404 rs775536014	393	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs760928923 CA9939405	394	T>M		No	ClinGen ExAC TOPMed gnomAD
CA409532359 rs1489453382	397	K>E		No	ClinGen TOPMed gnomAD
rs36107815 CA9939408	397	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs36107815 CA317224954	397	K>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1395910503 CA409532371	398	K>N		No	ClinGen gnomAD
CA409532372 rs1271348918	399	D>N		No	ClinGen TOPMed
CA409532383 rs1247738362	400	E>G		No	ClinGen gnomAD
CA9939411 rs140787599	400	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9939413 rs368420066	401	E>G		No	ClinGen ExAC gnomAD
CA409532390 rs368420066	401	E>V		No	ClinGen ExAC gnomAD
CA9939415 rs754647959	402	E>D		No	ClinGen ExAC gnomAD
CA9939416 rs199937384	404	M>V		No	ClinGen ExAC TOPMed gnomAD
rs752423235 CA9939417	405	S>N		No	ClinGen ExAC gnomAD
CA317225010 rs548214631	406	L>V		No	ClinGen 1000Genomes

No associated diseases with Q16186

No regional properties for Q16186

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q16186

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
proteasome complex	A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
proteasome regulatory particle, lid subcomplex	The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.

5 GO annotations of molecular function

Name	Definition
endopeptidase activator activity	Binds to and increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
molecular function inhibitor activity	A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target.
protease binding	Binding to a protease or a peptidase.
proteasome binding	Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation.
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

4 GO annotations of biological process

Name	Definition
proteasome assembly	The aggregation, arrangement and bonding together of a mature, active proteasome complex.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
transcription elongation by RNA polymerase II promoter	The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9JKV1	Adrm1	Proteasomal ubiquitin receptor ADRM1	Mus musculus (Mouse)	PR
O48726	RPN13	26S proteasome regulatory subunit RPN13	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MTTSGALFPS	LVPGSRGASN	KYLVEFRAGK	MSLKGTTVTP	DKRKGLVYIQ	QTDDSLIHFC
70	80	90	100	110	120
WKDRTSGNVE	DDLIIFPDDC	EFKRVPQCPS	GRVYVLKFKA	GSKRLFFWMQ	EPKTDQDEEH
130	140	150	160	170	180
CRKVNEYLNN	PPMPGALGAS	GSSGHELSAL	GGEGGLQSLL	GNMSHSQLMQ	LIGPAGLGGL
190	200	210	220	230	240
GGLGALTGPG	LASLLGSSGP	PGSSSSSSSR	SQSAAVTPSS	TTSSTRATPA	PSAPAAASAT
250	260	270	280	290	300
SPSPAPSSGN	GASTAASPTQ	PIQLSDLQSI	LATMNVPAGP	AGGQQVDLAS	VLTPEIMAPI
310	320	330	340	350	360
LANADVQERL	LPYLPSGESL	PQTADEIQNT	LTSPQFQQAL	GMFSAALASG	QLGPLMCQFG
370	380	390	400
LPAEAVEAAN	KGDVEAFAKA	MQNNAKPEQK	EGDTKDKKDE	EEDMSLD