AiPD: Autoinhibited Protein Database

Gene name	RPN13 (At2g26590, T9J22.26)
Protein name	26S proteasome regulatory subunit RPN13
Names	AtRPN13, 26S proteasome non-ATPase regulatory subunit 13
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G26590
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

98-222 (Predicted disordered autoinhibitory region) PR

98-222 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O48726-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH05598079	13	I>L	No	1000Genomes
ENSVATH05598078	25	Q>H	No	1000Genomes
ENSVATH13416936	76	V>I	No	1000Genomes
ENSVATH00249453	89	N>K	No	1000Genomes
ENSVATH05598071	102	P>T	No	1000Genomes
tmp_2_11313773_C_T	106	G>S	No	1000Genomes
ENSVATH14556189	117	Y>S	No	1000Genomes
ENSVATH13416889	124	F>L	No	1000Genomes
ENSVATH00249446	128	E>D	No	1000Genomes
ENSVATH13416887	131	A>P	No	1000Genomes
ENSVATH01900934	132	A>V	No	1000Genomes
ENSVATH05598054	137	E>G	No	1000Genomes
tmp_2_11312363_G_A	150	A>V	No	1000Genomes
tmp_2_11312333_G_A	160	S>L	No	1000Genomes
ENSVATH05598046	187	G>V	No	1000Genomes
tmp_2_11312154_T_C	191	I>V	No	1000Genomes
ENSVATH14556143	196	D>A	No	1000Genomes
tmp_2_11311855_C_T	222	R>Q	No	1000Genomes
ENSVATH05598037	225	S>L	No	1000Genomes
tmp_2_11311217_A_C	290	S>A	No	1000Genomes
ENSVATH05598028	293	S>L	No	1000Genomes
ENSVATH05598027	296	A>E	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Peptidase M14, carboxypeptidase A	191 - 589	IPR000834
domain	Frizzled domain	35 - 159	IPR020067
domain	Metallocarboxypeptidase Z, carboxypeptidase domain	184 - 498	IPR034239

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
proteasome regulatory particle, lid subcomplex	The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.

Name	Definition
endopeptidase activator activity	Binds to and increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
proteasome binding	Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation.
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

Name	Definition
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q16186	ADRM1	Proteasomal ubiquitin receptor ADRM1	Homo sapiens (Human)	PR
Q9JKV1	Adrm1	Proteasomal ubiquitin receptor ADRM1	Mus musculus (Mouse)	PR