AiPD: Autoinhibited Protein Database

Q15561

Gene name	TEAD4 (RTEF1, TCF13L1, TEF3)
Protein name	Transcriptional enhancer factor TEF-3
Names	TEA domain family member 4, TEAD-4, Transcription factor 13-like 1, Transcription factor RTEF-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7004
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-62 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

21 structures for Q15561

Entry ID	Method	Resolution	Chain	Position	Source
5GZB	X-ray	270 A	A	36-139	PDB
5NO6	X-ray	288 A	I/N	40-112	PDB
5OAQ	X-ray	195 A	A	217-434	PDB
6GE3	X-ray	185 A	A	216-434	PDB
6GE4	X-ray	197 A	A	216-434	PDB
6GE5	X-ray	205 A	A	216-434	PDB
6GE6	X-ray	180 A	A	216-434	PDB
6GEC	X-ray	170 A	A	216-434	PDB
6GEE	X-ray	196 A	A	216-434	PDB
6GEG	X-ray	223 A	A	216-434	PDB
6GEI	X-ray	165 A	A	216-434	PDB
6GEK	X-ray	228 A	A/B	216-434	PDB
6HIK	X-ray	165 A	A	216-434	PDB
6Q2X	X-ray	210 A	A	217-434	PDB
6Q36	X-ray	201 A	A/B	217-434	PDB
6SEN	X-ray	165 A	A/B	217-434	PDB
6SEO	X-ray	255 A	A	217-434	PDB
8A8R	X-ray	170 A	A/B	216-434	PDB
8C17	X-ray	225 A	A	217-434	PDB
8CAA	X-ray	200 A	A/B	217-434	PDB
AF-Q15561-F1	Predicted				AlphaFoldDB

346 variants for Q15561

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1354224261 CA383387054	3	G>A		No	ClinGen gnomAD
CA383387035 rs1382596093	3	G>S		No	ClinGen TOPMed
CA6392975 rs774772555	4	T>M		No	ClinGen ExAC gnomAD
rs764221350 CA6392980	6	G>S		No	ClinGen ExAC TOPMed gnomAD
rs138303433 CA6392982	7	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA383387272 rs1591572456	9	T>I		No	ClinGen Ensembl
rs1370141276 CA383387407	14	S>N		No	ClinGen gnomAD
CA6392984 rs765447889	16	P>S		No	ClinGen ExAC gnomAD
CA383387453 rs1591572462	17	T>P		No	ClinGen Ensembl
CA6392985 rs201308829	18	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1239272473 CA383387492	19	P>S		No	ClinGen TOPMed
rs1591572470 CA383387576	22	S>T		No	ClinGen Ensembl
CA6392987 rs780013542	23	T>I		No	ClinGen ExAC TOPMed gnomAD
CA6392986 rs758180158	23	T>P		No	ClinGen ExAC gnomAD
rs527238579 COSM938668 CA6392989	24	A>T	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs966389315 CA231651418	26	G>R		No	ClinGen Ensembl
CA383387718 rs1591572496	27	G>V		No	ClinGen Ensembl
CA6392992 rs747720325	28	S>T		No	ClinGen ExAC gnomAD
rs200185504 CA6392993	30	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA383387799 rs200185504	30	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA383387810 rs1185657389	30	A>V		No	ClinGen gnomAD
rs777338239 CA383387822	31	L>P		No	ClinGen ExAC TOPMed gnomAD
rs777338239 COSM431012 CA6392994	31	L>R	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6392995 rs201697096	32	D>E		No	ClinGen 1000Genomes ExAC gnomAD
rs772283648 CA6392996	33	K>R		No	ClinGen ExAC TOPMed gnomAD
rs776020891 CA6392997	35	I>V		No	ClinGen ExAC TOPMed gnomAD
rs376160263 CA6392999	36	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA6393000 rs776850143	37	N>S		No	ClinGen ExAC TOPMed gnomAD
rs776850143 CA383387989	37	N>T		No	ClinGen ExAC TOPMed gnomAD
CA383388018 rs1429257676	38	D>G		No	ClinGen gnomAD
rs1052141 CA6393002	39	A>E		No	ClinGen ExAC gnomAD
CA231651448 rs1052141	39	A>G		No	ClinGen ExAC gnomAD
rs1366402152 CA383388038	39	A>T		No	ClinGen TOPMed gnomAD
CA383388092 rs1219806086	41	G>S		No	ClinGen TOPMed gnomAD
rs763254392 CA6393004	42	V>M		No	ClinGen ExAC TOPMed gnomAD
rs751357181 CA6393006	44	S>R		No	ClinGen ExAC gnomAD
CA6393007 rs143364899	45	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6393009 rs752179602	47	I>T		No	ClinGen ExAC gnomAD
rs755618933 CA6393010	52	Q>*		No	ClinGen ExAC
CA231651462 rs769070539	52	Q>R		No	ClinGen Ensembl
rs113303358 CA231651464	53	E>G		No	ClinGen Ensembl
CA383388412 rs1383690211	56	A>D		No	ClinGen gnomAD
COSM1228853 rs148347828 CA6393012	56	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs756948709 CA6393013	57	I>V		No	ClinGen ExAC gnomAD
rs780501836 CA6393014	59	P>L		No	ClinGen ExAC gnomAD
CA6393017 rs777328851	61	C>W		No	ClinGen ExAC gnomAD
rs200040147 CA6393018	62	G>D		No	ClinGen 1000Genomes ExAC gnomAD
CA6393019 rs769725571	64	R>C		No	ClinGen ExAC gnomAD
CA383388576 rs769725571	64	R>G		No	ClinGen ExAC gnomAD
COSM938669 CA6393020 rs375587017	64	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
rs769725571 CA383388574	64	R>S		No	ClinGen ExAC gnomAD
CA6393021 rs763014154	68	L>P		No	ClinGen ExAC TOPMed gnomAD
rs377141915 CA6393022	69	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA6393024 rs148965461	70	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383388736 rs1295766311	71	E>K		No	ClinGen TOPMed
rs752536361 CA6393026	72	G>S		No	ClinGen ExAC TOPMed gnomAD
CA231651495 rs939971926	73	K>R		No	ClinGen TOPMed
CA6393028 rs763455765	74	M>I		No	ClinGen ExAC gnomAD
COSM938679 rs1291664123 CA383393063	77	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed
CA6393046 rs202176942	77	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA383393069 rs1591583945	78	N>D		No	ClinGen Ensembl
rs1173967174 CA383393136	83	R>C		No	ClinGen gnomAD
rs764955264 CA6393050	83	R>H		No	ClinGen ExAC TOPMed gnomAD
CA383393147 rs1214087190	84	Y>H		No	ClinGen gnomAD
rs1291388277 CA383393166	85	I>T		No	ClinGen gnomAD
CA383393183 rs1351833187	86	K>N		No	ClinGen gnomAD
rs750064191 CA6393051	88	R>Q		No	ClinGen ExAC gnomAD
CA231655652 rs1020125646	88	R>W		No	ClinGen TOPMed gnomAD
rs758150762 CA6393052	92	T>A		No	ClinGen ExAC gnomAD
rs1222867658 CA383393252	92	T>I		No	ClinGen TOPMed gnomAD
rs1003099496 CA231655656	93	R>C		No	ClinGen Ensembl
CA383393275 rs756562199	94	T>I		No	ClinGen ExAC gnomAD
CA6393055 rs756562199	94	T>S		No	ClinGen ExAC gnomAD
rs1484104558 CA383393311	97	Q>*		No	ClinGen gnomAD
rs1464770915 CA383393333	98	V>F		No	ClinGen gnomAD
CA6393074 rs764396295	99	S>P		No	ClinGen ExAC gnomAD
rs1480246582 CA383393375	104	V>L		No	ClinGen Ensembl
rs1163379333 CA383393383	105	L>R		No	ClinGen gnomAD
rs1368570211 CA383393389	106	A>V		No	ClinGen gnomAD
rs1459333292 CA383393392	107	R>C		No	ClinGen gnomAD
CA383393394 rs1591584846	107	R>P		No	ClinGen Ensembl
rs1287094137 CA383393398	108	R>C		No	ClinGen gnomAD
rs754294061 CA6393075	108	R>H		No	ClinGen ExAC TOPMed gnomAD
CA383393401 rs1591584865	109	K>Q		No	ClinGen Ensembl
rs1321453733 CA383393414	110	A>V		No	ClinGen TOPMed gnomAD
CA6393076 rs757774295	111	R>C		No	ClinGen ExAC gnomAD
CA383393418 rs1394515961	111	R>H		No	ClinGen TOPMed gnomAD
CA383393419 rs1394515961	111	R>L		No	ClinGen TOPMed gnomAD
CA6393078 rs746015510	112	E>K		No	ClinGen ExAC gnomAD
rs1334085813 CA383393429	113	I>F		No	ClinGen TOPMed
rs1565542235 CA383393432	113	I>M		No	ClinGen Ensembl
CA6393079 rs758536351	113	I>T		No	ClinGen ExAC gnomAD
CA383393434 rs780374211	114	Q>*		No	ClinGen ExAC gnomAD
CA6393080 rs780374211	114	Q>E		No	ClinGen ExAC gnomAD
rs941912696 CA231656054	115	A>G		No	ClinGen TOPMed gnomAD
rs941912696 CA383393444	115	A>V		No	ClinGen TOPMed gnomAD
rs1236362065 CA383393451	116	K>E		No	ClinGen TOPMed gnomAD
CA383393469 rs1378779269	117	L>Q		No	ClinGen TOPMed
CA383393482 rs1459214277	118	K>T		No	ClinGen TOPMed
CA6393103 rs769828815	119	D>H		No	ClinGen ExAC gnomAD
CA6393104 rs773320291	120	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs749267494 CA6393105	121	A>E		No	ClinGen ExAC gnomAD
CA383395103 rs1230053937	123	K>E		No	ClinGen gnomAD
rs1193727796 CA383395109	123	K>R		No	ClinGen TOPMed
CA6393106 rs770424147	124	D>N		No	ClinGen ExAC gnomAD
rs1591589393 CA383395150	125	K>R		No	ClinGen Ensembl
rs1337181746 CA383395241	129	S>N		No	ClinGen TOPMed
rs1337181746 CA383395244	129	S>T		No	ClinGen TOPMed
CA383395274 rs1273998522	130	M>R		No	ClinGen TOPMed
CA383395271 rs1273998522	130	M>T		No	ClinGen TOPMed
rs767142386 CA383395294	131	A>P		No	ClinGen ExAC gnomAD
rs767142386 CA6393109	131	A>T		No	ClinGen ExAC gnomAD
CA383395326 rs1186903984	133	M>L		No	ClinGen gnomAD
rs762215851 COSM1228852 CA6393111	134	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs375377144 CA6393113	136	A>V		No	ClinGen ESP ExAC gnomAD
rs763394861 CA6393114	137	Q>R		No	ClinGen ExAC gnomAD
COSM1492893 rs117484952 CA6393117	141	A>T	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA383395453 rs1326407755	142	T>M		No	ClinGen TOPMed
CA383395484 rs1436866573	145	H>N		No	ClinGen gnomAD
CA383395492 rs1281870739	145	H>R		No	ClinGen gnomAD
rs752507117 CA6393119	146	S>G		No	ClinGen ExAC TOPMed gnomAD
CA383395528 CA383395527 rs1292023322	147	S>R		No	ClinGen TOPMed gnomAD
CA383395540 rs1459552661	148	M>T		No	ClinGen TOPMed
rs576443873 CA231658863	149	A>V		No	ClinGen gnomAD
rs1290903018 CA383395573 COSM1512031	151	A>S	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA383395575 rs1290903018	151	A>T		No	ClinGen TOPMed gnomAD
CA6393122 rs535488654	151	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA231658870 rs929337081	152	R>Q		No	ClinGen TOPMed gnomAD
CA6393123 rs369932433	152	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA6393124 rs770787414	153	G>V		No	ClinGen ExAC gnomAD
CA383395616 rs150590022	155	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6393126 rs150590022	155	G>S		No	ClinGen ExAC TOPMed gnomAD
rs373626483 CA6393127	156	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6393128 rs139665156	156	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1331834037 CA383395651	158	A>S		No	ClinGen TOPMed gnomAD
rs1331834037 CA383395649	158	A>T		No	ClinGen TOPMed gnomAD
CA383395657 rs1339358801	158	A>V		No	ClinGen gnomAD
rs367751748 CA6393130	159	V>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1285461716 CA383395676	160	S>*		No	ClinGen gnomAD
CA6393131 rs149743004	161	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6393146 rs779568456	163	W>R		No	ClinGen ExAC gnomAD
rs1565545430 CA383395730	164	Q>E		No	ClinGen Ensembl
CA231659732 rs987214567	164	Q>L		No	ClinGen Ensembl
CA231659745 rs746594673	166	A>G		No	ClinGen ExAC TOPMed gnomAD
CA6393147 rs746594673	166	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1448859001 CA383395748	167	L>S		No	ClinGen TOPMed
rs866378032 CA231659767	169	G>D		No	ClinGen Ensembl
rs200746125 CA6393149	172	G>R		No	ClinGen ExAC TOPMed gnomAD
CA6393150 rs144567026	173	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1440072332 CA383395852	174	S>F		No	ClinGen gnomAD
CA6393152 rs774674986	175	H>L		No	ClinGen ExAC gnomAD
rs766365802 CA6393183	179	P>R		No	ClinGen ExAC gnomAD
rs1555127560 CA383396402	179	P>S		No	ClinGen Ensembl
CA6393184 rs556052032	181	S>F		No	ClinGen 1000Genomes ExAC gnomAD
rs935421118 CA231660254	183	Q>E		No	ClinGen Ensembl
CA383396467 rs1309375945	184	T>A		No	ClinGen gnomAD
CA231660256 rs989537357	184	T>I		No	ClinGen TOPMed gnomAD
rs754439456 CA6393185	185	Y>D		No	ClinGen ExAC gnomAD
rs755806437 CA6393188	187	V>A		No	ClinGen ExAC TOPMed gnomAD
CA6393187 rs747692032	187	V>L		No	ClinGen ExAC TOPMed gnomAD
CA231660280 rs896397769	189	P>T		No	ClinGen TOPMed
CA6393189 rs779133956	190	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6393190 rs370063341	192	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1186747513 CA383396587	195	G>R		No	ClinGen gnomAD
CA383396744 rs1185664866	197	E>G		No	ClinGen TOPMed
CA383396738 rs1350253314	197	E>Q		No	ClinGen TOPMed gnomAD
rs1224622323 CA383396761	198	S>F		No	ClinGen gnomAD
rs1484777838 CA383396771	199	P>L		No	ClinGen TOPMed
rs1309624293 CA383396766	199	P>S		No	ClinGen gnomAD
CA6393218 rs763197038	200	A>S		No	ClinGen ExAC gnomAD
CA6393219 rs763197038	200	A>T		No	ClinGen ExAC gnomAD
CA231661595 rs146443432	200	A>V		No	ClinGen ESP gnomAD
rs545767625 CA6393220	201	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1565546622 CA383396797	202	P>S		No	ClinGen Ensembl
rs371373848 CA6393224	203	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs371373848 CA6393223 COSM178540	203	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs753500375 CA6393226	205	S>L		No	ClinGen ExAC TOPMed gnomAD
rs140809000 CA6393225	205	S>T		No	ClinGen ESP ExAC gnomAD
CA6393227 rs756972096	207	S>F		No	ClinGen ExAC TOPMed gnomAD
CA6393228 rs374365771	208	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA6393230 rs755432905	209	P>L		No	ClinGen ExAC gnomAD
rs1591592014 CA383396873	209	P>S		No	ClinGen Ensembl
CA6393231 rs199662990	210	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756183214 CA6393233	211	A>T		No	ClinGen ExAC TOPMed gnomAD
rs143114313 CA6393234	211	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1021485033 CA231661727	215	Q>E		No	ClinGen TOPMed gnomAD
rs1440879034 CA383396992	217	R>C		No	ClinGen TOPMed gnomAD
CA6393235 rs151141907	217	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs367723028 CA6393237	219	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1480094508 CA383397105	222	S>P		No	ClinGen TOPMed
CA231661752 rs957492113	223	K>R		No	ClinGen TOPMed
rs1206572490 CA383397207 CA383397205	225	W>C		No	ClinGen gnomAD
CA6393239 rs375896668	226	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1488061158 CA383397264	228	E>K		No	ClinGen gnomAD
CA383397284 rs1252042208	229	F>L		No	ClinGen TOPMed
CA6393240 rs775449465	230	S>C		No	ClinGen ExAC gnomAD
rs1253793632 CA383397329	232	F>S		No	ClinGen gnomAD
rs141118300 CA6393241	236	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs763628398 CA6393242	237	Q>K		No	ClinGen ExAC gnomAD
rs1410988798 CA383397459	239	P>A		No	ClinGen TOPMed gnomAD
CA6393243 rs71583736	239	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383397462 rs1410988798	239	P>S		No	ClinGen TOPMed gnomAD
CA383397488 rs1436293237	240	D>G		No	ClinGen gnomAD
CA383397513 rs765047253	241	T>K		No	ClinGen ExAC TOPMed gnomAD
CA6393245 rs765047253	241	T>M		No	ClinGen ExAC TOPMed gnomAD
CA6393276 rs779884533	242	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs1591592919 CA383398109	245	H>P		No	ClinGen Ensembl
rs1007919145 CA231662944	246	L>P		No	ClinGen TOPMed
CA6393278 rs768680578	247	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1402110482 CA383398140	247	F>Y		No	ClinGen gnomAD
rs1415302307 CA383398158	248	V>E		No	ClinGen gnomAD
CA231662964 rs1017929050	248	V>L		No	ClinGen TOPMed gnomAD
CA383398152 rs1017929050	248	V>M		No	ClinGen TOPMed gnomAD
rs1490699816 CA383398192	250	I>T		No	ClinGen TOPMed
CA383398199 rs1348391906	251	G>S		No	ClinGen gnomAD
rs781323637 CA6393279	252	Q>*		No	ClinGen ExAC gnomAD
CA383398227 rs748114401	252	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1208933668 CA383398320	258	S>G		No	ClinGen TOPMed
CA383398342 rs1591592964	259	D>A		No	ClinGen Ensembl
CA231663005 rs903431864	259	D>E		No	ClinGen TOPMed gnomAD
rs1225713927 CA383398340	259	D>N		No	ClinGen gnomAD
rs1485412434 CA383398352	260	P>S		No	ClinGen gnomAD
CA231663014 rs202053088	261	Y>C		No	ClinGen 1000Genomes
CA383398371 rs202053088	261	Y>S		No	ClinGen 1000Genomes
CA6393283 COSM938723 rs762656664	263	E>K	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs201149385 CA6393285	265	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA383398443 rs761078905	267	I>F		No	ClinGen ExAC TOPMed
rs761078905 CA6393286	267	I>V		No	ClinGen ExAC TOPMed
COSM1267595 rs141718322 CA6393287	268	R>C	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA6393288 rs754304508	268	R>H		No	ClinGen ExAC TOPMed gnomAD
rs754304508 CA6393289	268	R>L		No	ClinGen ExAC TOPMed gnomAD
rs765302453 CA6393290	271	Y>C		No	ClinGen ExAC gnomAD
CA383398501 rs765302453	271	Y>F		No	ClinGen ExAC gnomAD
rs373793296 CA6393292	275	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1409156460 CA383398581	277	K>E		No	ClinGen gnomAD
CA383398605 rs1337348966	278	K>T		No	ClinGen gnomAD
rs138509952 CA6393295	284	L>F		No	ClinGen 1000Genomes ExAC gnomAD
rs138509952 CA6393296	284	L>V		No	ClinGen 1000Genomes ExAC gnomAD
rs147065257 CA383398729	287	R>P		No	ClinGen ESP TOPMed gnomAD
rs147065257 CA231663147	287	R>Q		No	ClinGen ESP TOPMed gnomAD
CA231663136 rs555272304	287	R>W		No	ClinGen 1000Genomes TOPMed gnomAD
rs769682182 CA6393298	288	G>R		No	ClinGen ExAC gnomAD
CA383398746 rs1340612123	289	P>H		No	ClinGen gnomAD
rs867226875 CA231663155	289	P>S		No	ClinGen Ensembl
rs777335307 CA383398762	290	S>C		No	ClinGen ExAC TOPMed gnomAD
CA6393299 rs777335307	290	S>F		No	ClinGen ExAC TOPMed gnomAD
CA6393300 rs571778933	291	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs534152841 CA6393301	292	A>T		No	ClinGen 1000Genomes ExAC
CA383398790 rs1252243357	293	F>I		No	ClinGen TOPMed
rs759218732 CA6393303	295	L>V		No	ClinGen ExAC gnomAD
rs776992627 CA6393305	298	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1313720511 CA383381703	301	D>N		No	ClinGen gnomAD
rs763983673 CA6393333	304	T>A		No	ClinGen ExAC TOPMed gnomAD
rs753653815 CA6393334	305	N>S		No	ClinGen ExAC TOPMed gnomAD
CA383381739 COSM3704066 rs1265923337	306	I>F	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
rs529565656 CA6393336	306	I>M		No	ClinGen ExAC TOPMed gnomAD
CA383381749 rs758015153	307	E>D		No	ClinGen ExAC gnomAD
rs745449009 CA6393337	307	E>K		No	ClinGen ExAC gnomAD
rs779726504 CA6393339	308	D>V		No	ClinGen ExAC gnomAD
CA231658255 rs1028228180	310	G>D		No	ClinGen TOPMed gnomAD
rs867635120 CA231658277	312	S>F		No	ClinGen Ensembl
CA383381828 rs1591603359	314	Y>*		No	ClinGen Ensembl
rs536669411 CA6393345	314	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs536669411 CA6393344	314	Y>S		No	ClinGen 1000Genomes ExAC gnomAD
CA6393346 rs774546561	316	V>A		No	ClinGen ExAC gnomAD
rs759741797 CA6393347	317	S>P		No	ClinGen ExAC gnomAD
rs1441684016 CA383381935	322	S>I		No	ClinGen TOPMed
CA383381933 rs1441684016	322	S>T		No	ClinGen TOPMed
rs11550887 CA6393350 VAR_052279	323	P>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1172254434 CA383381980	324	E>D		No	ClinGen TOPMed
CA231658333 rs987014448	324	E>K		No	ClinGen TOPMed gnomAD
rs753722673 CA6393352	325	N>K		No	ClinGen ExAC gnomAD
CA383382080 rs1482024630	328	I>S		No	ClinGen gnomAD
rs200483208 CA6393353	329	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6393354 rs371946304	330	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6393355 rs749911955	331	S>F		No	ClinGen ExAC TOPMed gnomAD
CA6393357 rs779566440	332	T>M		No	ClinGen ExAC TOPMed gnomAD
rs912429601 CA231658353	333	K>T		No	ClinGen TOPMed
CA231658377 rs76933440	338	G>D		No	ClinGen Ensembl
rs1263352356 CA383382254	338	G>S		No	ClinGen gnomAD
CA6393359 rs767356667	339	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1307767017 CA383382295	340	Q>*		No	ClinGen TOPMed
rs1223331098 CA383382305	340	Q>H		No	ClinGen TOPMed
rs1417731247 CA383382328	342	V>L		No	ClinGen gnomAD
rs757656318 CA6393380	348	E>K		No	ClinGen ExAC TOPMed gnomAD
CA383383162 rs1412328792	350	A>V		No	ClinGen TOPMed
CA6393381 rs143259791	351	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746321600 CA6393382	351	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1182324160 CA383383185	352	Y>*		No	ClinGen TOPMed
CA231659888 rs369711969	352	Y>F		No	ClinGen ESP TOPMed gnomAD
CA383383216 rs1253693371	355	G>R		No	ClinGen gnomAD
CA383383230 rs1591605094	356	H>R		No	ClinGen Ensembl
CA383383225 rs1482910821	356	H>Y		No	ClinGen TOPMed
rs772765432 CA6393384	357	Y>*		No	ClinGen ExAC gnomAD
rs1419356207 CA383383272	359	Y>*		No	ClinGen TOPMed gnomAD
CA383383263 rs1184865351	359	Y>D		No	ClinGen gnomAD
rs148295237 CA6393385	360	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA383383281 rs1172939530	360	R>H		No	ClinGen TOPMed gnomAD
CA6393386 rs148295237	360	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs776863179 CA6393387	361	I>F		No	ClinGen ExAC TOPMed gnomAD
rs1326238086 CA383383313	363	R>Q		No	ClinGen gnomAD
rs887754938 COSM938733 CA231659908	363	R>W	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA383383337 rs1396026469	365	P>L		No	ClinGen TOPMed gnomAD
CA383383335 rs1396026469	365	P>Q		No	ClinGen TOPMed gnomAD
rs1379140974 CA687174376	367	C>*		No	ClinGen TOPMed
rs1436724825 CA383383408	370	M>I		No	ClinGen TOPMed
rs1388733012 CA383383423	372	N>D		No	ClinGen TOPMed
rs1362508195 CA383383426	372	N>S		No	ClinGen gnomAD
rs1388733012 CA383383424	372	N>Y		No	ClinGen TOPMed
CA6393389 rs769507018	375	H>L		No	ClinGen ExAC gnomAD
rs773002468 CA6393390	375	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs141376355 CA6393391	376	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6393392 rs766383485	378	K>Q		No	ClinGen ExAC gnomAD
rs373443172 CA6393393	378	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA6393395 rs766970807	383	K>E		No	ClinGen ExAC gnomAD
rs1486462821 CA383383590	383	K>T		No	ClinGen gnomAD
rs568432444 CA6393396	384	Y>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs910307904 CA383383614	385	M>L		No	ClinGen TOPMed
rs910307904 CA231660015	385	M>V		No	ClinGen TOPMed
CA383383631 rs1475123488	386	M>L		No	ClinGen gnomAD
CA6393398 rs755845240	386	M>T		No	ClinGen ExAC gnomAD
CA383383684 rs1316966542	389	V>M		No	ClinGen TOPMed gnomAD
CA231660039 rs902014352	391	E>D		No	ClinGen TOPMed
CA383383785 rs1591605200	394	T>P		No	ClinGen Ensembl
CA231660213 rs1035099586	403	D>N		No	ClinGen Ensembl
CA231660220 rs896503133	405	Q>*		No	ClinGen Ensembl
CA383384118 rs1279803067	405	Q>R		No	ClinGen gnomAD
CA383384150 rs912933244 COSM1288412	406	E>D	autonomic_ganglia [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA383384130 rs1393998467	406	E>Q		No	ClinGen gnomAD
CA383384166 rs1174306516	407	T>N		No	ClinGen gnomAD
CA231660243 rs1020888840	410	C>F		No	ClinGen TOPMed gnomAD
CA383384209 rs1336523863	410	C>R		No	ClinGen gnomAD
CA383384240 rs1301295641	411	I>N		No	ClinGen TOPMed gnomAD
CA6393433 rs768302943	413	Y>C		No	ClinGen ExAC gnomAD
CA383384279 rs1277055105	414	V>I		No	ClinGen gnomAD
rs1195546851 CA383384305	416	E>V		No	ClinGen gnomAD
rs1301466750 CA383384311	417	V>M		No	ClinGen TOPMed
rs1365177021 CA383384334	419	A>T		No	ClinGen TOPMed
rs779330383 CA231660279	423	G>R		No	ClinGen gnomAD
CA6393437 rs751923397	426	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA231660318 rs368628079	427	H>Y		No	ClinGen ESP TOPMed gnomAD
rs1168238612 CA383384539	430	R>K		No	ClinGen gnomAD
rs756149930 CA6393441	432	V>G		No	ClinGen ExAC TOPMed gnomAD
rs753228454 CA6393440	432	V>L		No	ClinGen ExAC gnomAD
CA6393442 rs777839953	433	K>E		No	ClinGen ExAC gnomAD
rs754035071 CA231660342 CA6393443	435	E>R		No	ClinGen ExAC gnomAD

No associated diseases with Q15561

2 regional properties for Q15561

Type	Name	Position	InterPro Accession
domain	TEA/ATTS domain	34 - 112	IPR000818
domain	YAP binding domain	222 - 431	IPR041086

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-DNA complex	A macromolecular complex containing both protein and DNA molecules.
transcription regulator complex	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

4 GO annotations of molecular function

Name	Definition
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

9 GO annotations of biological process

Name	Definition
cell fate specification	The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
embryo implantation	Attachment of the blastocyst to the uterine lining.
embryonic organ development	Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
hippo signaling	The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
muscle organ development	The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
positive regulation of stem cell population maintenance	Any process that activates or increases the frequency, rate or extent of stem cell population maintenance.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
skeletal system development	The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
trophectodermal cell fate commitment	The cell fate commitment of precursor cells that will become trophectoderm cells.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P48984	TEAD4	Transcriptional enhancer factor TEF-3	Gallus gallus (Chicken)	PR
Q62296	Tead4	Transcriptional enhancer factor TEF-3	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MEGTAGTITS	NEWSSPTSPE	GSTASGGSQA	LDKPIDNDAE	GVWSPDIEQS	FQEALAIYPP
70	80	90	100	110	120
CGRRKIILSD	EGKMYGRNEL	IARYIKLRTG	KTRTRKQVSS	HIQVLARRKA	REIQAKLKDQ
130	140	150	160	170	180
AAKDKALQSM	AAMSSAQIIS	ATAFHSSMAL	ARGPGRPAVS	GFWQGALPGQ	AGTSHDVKPF
190	200	210	220	230	240
SQQTYAVQPP	LPLPGFESPA	GPAPSPSAPP	APPWQGRSVA	SSKLWMLEFS	AFLEQQQDPD
250	260	270	280	290	300
TYNKHLFVHI	GQSSPSYSDP	YLEAVDIRQI	YDKFPEKKGG	LKDLFERGPS	NAFFLVKFWA
310	320	330	340	350	360
DLNTNIEDEG	SSFYGVSSQY	ESPENMIITC	STKVCSFGKQ	VVEKVETEYA	RYENGHYSYR
370	380	390	400	410	420
IHRSPLCEYM	INFIHKLKHL	PEKYMMNSVL	ENFTILQVVT	NRDTQETLLC	IAYVFEVSAS
430
EHGAQHHIYR	LVKE