Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q12244

Entry ID Method Resolution Chain Position Source
AF-Q12244-F1 Predicted AlphaFoldDB

26 variants for Q12244

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-35033 57 I>M No SGRP
s12-35023 61 P>S No SGRP
s12-34857 116 D>G No SGRP
s12-34785 140 E>G No SGRP
s12-34089 372 I>T No SGRP
s12-34023 394 Y>C No SGRP
s12-33534 557 I>T No SGRP
s12-33490 572 S>R No SGRP
s12-33462 581 C>S No SGRP
s12-33424 594 R>C No SGRP
s12-33368 612 E>D No SGRP
s12-33352 618 L>F No SGRP
s12-33348 619 L>R No SGRP
s12-33300 635 F>Y No SGRP
s12-33277 643 F>L No SGRP
s12-33142 688 Y>H No SGRP
s12-33111 698 I>T No SGRP
s12-33094 704 S>G No SGRP
s12-32970 745 Y>C No SGRP
s12-32928 759 G>A No SGRP
s12-32919 762 K>R No SGRP
s12-32861 782 E>K No SGRP
s12-32843 788 E>Q No SGRP
s12-32827 793 A>G No SGRP
s12-32702 835 G>R No SGRP
s12-32690 839 N>D No SGRP

No associated diseases with Q12244

1 regional properties for Q12244

Type Name Position InterPro Accession
domain Zn(2)Cys(6) fungal-type DNA-binding domain 9 - 53 IPR001138

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P36023 OAF3 Oleate activated transcription factor 3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q06639 RSC3 Chromatin structure-remodeling complex protein RSC3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MSIASQKKVK PSFVCLRCKQ RKIKCDKLWP TCSKCKASSS ICSYEVEPGR INKSPTIENA
70 80 90 100 110 120
PHRDIRNITP ASMSASGSFT SILNPSTKDW EMKNFAMNLS NAHDKLVVMN NTTIVDSPFA
130 140 150 160 170 180
FHSILQHDLY AKALTTCIHE RILIDVERHR ENVSANNKKR ELNLTIGDIG PLFFIDKAAL
190 200 210 220 230 240
KFIENTSKTS KLYPPIDFLY NTYDYEQAHP EENNDKISIN ILLEELSKYF LNKNEVDGLI
250 260 270 280 290 300
VDFYKTIYPV YPLLEISLFE DNIRELLQLN EFNGYNIVFA GKDSRRKLET ITLLTIILAF
310 320 330 340 350 360
SYRRLSLSTS HSFKESFGVK SNNLTLLAHK LLALMNVFQY VNEHTLCCLL YFFILRYLNP
370 380 390 400 410 420
DQADMYPTHS DILNLKFLEN VAIKLGLNEE PFQYTRYVSE SDDYPRLFNL RRKLWLGVQF
430 440 450 460 470 480
LKFGILIPEG DSDILSLEYL RSFMKTDESL PELFERNYAS TNNLDLSLMA TAENIYHLHL
490 500 510 520 530 540
SLQVLLTSCF PINGPSYLKE VLDNIDKTKD FLNQKFPLIL SSLGEPRMKS LHINVPSSLA
550 560 570 580 590 600
NEESFDFSTF EENETFIANV ISYTCTMNIY DSLSLHFENQ CFKNALEYKT YYHRFTFTAI
610 620 630 640 650 660
QDYLTLLKLI SEYFNGSLLH LREPFGFATQ KVVRFSIHRL LIFQATLLVR LFYKKDTCDR
670 680 690 700 710 720
SSAAMGMLND RNGRLSRVIE KMIKLMSYHM KLLVEIVISK LEKSYLGSFI SVSIFRYIIY
730 740 750 760 770 780
LVDTDALSAF ISDYWKSDAV MDERYSRIHR IVGLKWGMGR DKSFSFTSKL NNPQFLGSLD
790 800 810 820 830 840
LEILEELEKL ISAQEFSRNF TEDVDESLQS EIDLMNYDNE ALNQLMAIDL DKLLGIFPNL
SNF