Q06639

PR
Gene name
RSC3 (YDR303C, D9740.13)
Protein name
Chromatin structure-remodeling complex protein RSC3
Names
Remodel the structure of chromatin complex subunit 3
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR303C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

30-172 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q06639

Entry ID Method Resolution Chain Position Source
6K15 EM 340 A K 1-885 PDB
6KW3 EM 713 A K 1-885 PDB
6KW4 EM 755 A K 1-885 PDB
6KW5 EM 1013 A K 1-885 PDB
6V8O EM 307 A G 1-885 PDB
6V92 EM 2000 A G 1-885 PDB
AF-Q06639-F1 Predicted AlphaFoldDB

6 variants for Q06639

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-1071169 72 S>T No SGRP
s04-1070850 178 I>T No SGRP
s04-1070449 312 P>S No SGRP
s04-1069989 465 L>S No SGRP
s04-1069083 767 T>S No SGRP
s04-1069018 789 K>E No SGRP

No associated diseases with Q06639

1 regional properties for Q06639

Type Name Position InterPro Accession
domain Zn(2)Cys(6) fungal-type DNA-binding domain 8 - 53 IPR001138

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Localizes to centromeric and flanking chromatin
  • Association with these loci is dependent on STH1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RSC-type complex A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
zinc ion binding Binding to a zinc ion (Zn).

6 GO annotations of biological process

Name Definition
chromatin remodeling A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
nucleosome disassembly The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of nuclear cell cycle DNA replication Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P36023 OAF3 Oleate activated transcription factor 3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q12244 YLL054C Uncharacterized transcriptional regulatory protein YLL054C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MDIRGRKMKK PPACVQCRKR KIGCDRVKPI CGNCMKHNKM DCFYPDVPGQ YVPSSSSSSN
70 80 90 100 110 120
TRQVANGPYL NSYYASRRVS KETAALLQKN PELASLEQIR EYNTRLQLLN AQNQLNNRSS
130 140 150 160 170 180
AANATLNQQH TQYIPKSVPS LESKPVTSAN ESSTPLNWVQ GPAIFHMLTS PYTQDEIINH
190 200 210 220 230 240
EMNFLKGRLL ELQEITGKKI TGVNLDLKQD SSAQMQSSHS NRNQEEFLTI KKRKLSEDGV
250 260 270 280 290 300
TDGDGKPIPE SERRPHLNEF KDLDPQFLDT NKVFNVFNSA ISEEGRNRLW LLPKNINKSS
310 320 330 340 350 360
IFQIQYLIER DPFLFKFFND LNILIETQFN GPLHDLVASR NSIERNSGIS QILKFPSQSI
370 380 390 400 410 420
TQTLINKYLS TITETNSILP ILKPKRLLPI VEQLFPSNTI NKPNSKDFET IFQVFSVTND
430 440 450 460 470 480
QLLNLGFITL CLLILFESLN STVLIPLRDD EHLQLFNVLF NYLPLLKSNL TTLRFEIEKR
490 500 510 520 530 540
SMCNIETLRF ISLWKYYQFV MDTSSSSSFV IDYDEDMHMA CLLSLNHETQ NQSHILTWNF
550 560 570 580 590 600
IFKNYCWRHL FLGQLPLLMS EPFTNSTPII DPLLNNDFEL IDFEVNLMKY LQSKDQQLSI
610 620 630 640 650 660
DKIIQLIKLL KNKNIEVSQG CLTTPSIINN IMDSLIYRNS MLYLNFYLLL QFETLKNYAK
670 680 690 700 710 720
FNEILEDFLE LSRETLFFVF SNLANIKFAG HEFTFINKSI VVLQTLVLML LALYQRSFDS
730 740 750 760 770 780
SKRTNDANEI SEQTDIHSNN DNSKRIKNKN VIHLIINKIA MLLSDYTKNC KKQNKLIENL
790 800 810 820 830 840
IIKIKTISKY IKNLEENKVT TSADSNYSIN NGFSGISAEQ LIKLNHELSK ISESLIKTDF
850 860 870 880
YEQRKNSTVS NGVLGAAAPV DSDANSDTFG LTKENFNEVF EAIRS