Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P36023

Entry ID Method Resolution Chain Position Source
AF-P36023-F1 Predicted AlphaFoldDB

21 variants for P36023

Variant ID(s) Position Change Description Diseaes Association Provenance
s11-562263 25 R>S No SGRP
s11-562354 56 Q>K No SGRP
s11-562381 65 D>N No SGRP
s11-562492 102 V>I No SGRP
s11-562501 105 L>F No SGRP
s11-562508 107 N>S No SGRP
s11-562574 129 N>S No SGRP
s11-562666 160 A>T No SGRP
s11-562823 212 G>D No SGRP
s11-562915 243 S>G No SGRP
s11-562981 265 A>T No SGRP
s11-563032 282 V>I No SGRP
s11-563089 301 I>V No SGRP
s11-563279 364 N>I No SGRP
s11-563283 365 L>F No SGRP
s11-563392 402 S>A No SGRP
s11-564244 686 N>D No SGRP
s11-564262 692 D>N No SGRP
s11-564357 723 N>K No SGRP
s11-564511 775 E>K No SGRP
s11-564656 823 I>T No SGRP

No associated diseases with P36023

1 regional properties for P36023

Type Name Position InterPro Accession
domain Zn(2)Cys(6) fungal-type DNA-binding domain 13 - 58 IPR001138

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12244 YLL054C Uncharacterized transcriptional regulatory protein YLL054C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q06639 RSC3 Chromatin structure-remodeling complex protein RSC3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MGYDSQVRTK KRHRITVVCT NCKKRKSKCD RTKPCGTCVR LGDVDSCVYL TDSSGQPESS
70 80 90 100 110 120
PSLNDADPLR KQSTPAERIS PGFIKKRRSS QTRQDEDHWQ RVRELENQSS LYYLPIHEET
130 140 150 160 170 180
PFFIDLIPNG FYLETKRSAD NLFGLFTDRA IENRDPYLQA MVTFRSIAIK KMMDKLGSNG
190 200 210 220 230 240
NNVKNGSLPK SFEALSTFDA DDERHISDDV VGKGNNFRMH QTIHKSLFNK FAQYRENNAK
250 260 270 280 290 300
KFSSETILAK DYLPPLKILE SEVLALFEEK IYNMIPIFDM KVLRHEITIF YQNIVEKGNP
310 320 330 340 350 360
ISIKHYDHMV FCIILLIIKI CRLSVQFSKL TPYIYPVLQE IDTSKFLALV KHYLFETKVL
370 380 390 400 410 420
RKCNLLQLQC LILLRFLHWC APEDGDGPET QYCQILMGTI ISSCKEMGIN WYCFSHPEKY
430 440 450 460 470 480
SFKINRHTRP SYDIMKPSDY ISVFRKIWSY VLFWDRKMCF ISGEECQIGK TLQCHFKEEA
490 500 510 520 530 540
DTPTWYIRML TLDNLMKKIN DTLNDDPGKV DLNLLHRLIN DLKRNFHILK SLSKNEKETM
550 560 570 580 590 600
RHFDFEMEWI IDLFSLSLLH GEMIFYEYDC NITKFYKSFQ DLWDMVIHIS EKCYNYFFNS
610 620 630 640 650 660
DALEVDSLTK FYTNRIVEIV ANKVLVIVPA FILRGDRFKT IQYADKKKMI EFLYGVSSVY
670 680 690 700 710 720
FNEFGFEYYR CFRKMFTAKI AYKILNRSCE KDAWRIILKF LLNELKLEDN GDSYIDYNDM
730 740 750 760 770 780
RLNDICPIIL EFQETVQKYD GYRPDILSIW NNEFYPIGKY NDDMTGFKFQ MRIKEMQEFL
790 800 810 820 830 840
DMEKYSDRFN IFSSFYDHAS SQLAKHTEVD TNISITNEQV AEIPQKELLQ QPLAPALPVN
850 860
DLIVSEFDVI EDIFDPVDFV SFF