Q10051
PR
Gene name |
prp-19 (T10F2.4) |
Protein name |
Pre-mRNA-processing factor 19 |
Names |
PRP19/PSO4 homolog, RING-type E3 ubiquitin transferase PRP19 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
|
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q10051
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q10051-F1 | Predicted | AlphaFoldDB |
No variants for Q10051
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q10051 | |||||
No associated diseases with Q10051
10 regional properties for Q10051
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 190 - 237 | IPR001680-1 |
| repeat | WD40 repeat | 240 - 321 | IPR001680-2 |
| repeat | WD40 repeat | 327 - 449 | IPR001680-3 |
| repeat | WD40 repeat | 452 - 492 | IPR001680-4 |
| domain | U-box domain | 1 - 72 | IPR003613 |
| domain | Pre-mRNA-splicing factor 19 | 70 - 134 | IPR013915 |
| conserved_site | WD40 repeat, conserved site | 395 - 409 | IPR019775 |
| repeat | G-protein beta WD-40 repeat | 266 - 280 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 353 - 367 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 395 - 409 | IPR020472-3 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Prp19 complex | A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. |
| U2-type catalytic step 1 spliceosome | A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| nuclear mRNA surveillance | A process that identifies and degrades defective or aberrant mRNAs within the nucleus. |
| protein K63-linked ubiquitination | A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFVCGISGE | LTEDPVVSQV | SGHIFDRRLI | VKFIAENGTD | PISHGELSED | QLVSLKSGGT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GSAPRNVSGT | SIPSLLKMLQ | DEWDTVMLNS | FSLRQQLQIA | RQELSHSLYQ | HDAACRVISR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LSKELTAARE | ALSTLKPHTS | AKVDDDVSID | ESEDQQGLSE | AILAKLEEKS | KSLTAERKQR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GKNLPEGLAK | TEELAELKQT | ASHTGIHSTG | TPGITALDIK | GNLSLTGGID | KTVVLYDYEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EQVMQTFKGH | NKKINAVVLH | PDNITAISAS | ADSHIRVWSA | TDSSSKAIID | VHQAPVTDIS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LNASGDYILS | ASDDSYWAFS | DIRSGKSLCK | VSVEPGSQIA | VHSIEFHPDG | LIFGTGAADA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VVKIWDLKNQ | TVAAAFPGHT | AAVRSIAFSE | NGYYLATGSE | DGEVKLWDLR | KLKNLKTFAN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EEKQPINSLS | FDMTGTFLGI | GGQKVQVLHV | KSWSEVVSLS | DHSGPVTGVR | FGENARSLVT |
| 490 | |||||
| CSLDKSLRVF | SF |