Q10042

PR
Gene name
K01A12.3
Protein name
Probable G-protein coupled receptor K01A12.3
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_K01A12.3
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-151 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10042

Entry ID Method Resolution Chain Position Source
AF-Q10042-F1 Predicted AlphaFoldDB

No variants for Q10042

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10042

No associated diseases with Q10042

4 regional properties for Q10042

Type Name Position InterPro Accession
domain Zinc finger, ZZ-type 91 - 146 IPR000433
domain SANT/Myb domain 154 - 198 IPR001005
domain SWIRM domain 471 - 562 IPR007526
domain ADA2-like, zinc finger, ZZ-type 95 - 141 IPR041983

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

1 GO annotations of biological process

Name Definition
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6TLI7 ADORA2A Adenosine receptor A2a Equus caballus (Horse) PR
P28647 Adora3 Adenosine receptor A3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MESVTRHRAD MISFFTFDSY ISIVGVAYTA VGLLGVFCNV TTVIMILTNR VFRLSAYTIM
70 80 90 100 110 120
ANVALADSIV MLIAGVACGM DVMWPNPNDL TSFIPSLEEP YQKIAPVSLR NDSKTDSSAA
130 140 150 160 170 180
GFETGNIHAV LSFSFVAAWT AGVISYAMLG TNRCIAICYY GTKARALNQV SVAVACSAST
190 200 210 220 230 240
WIVGIAAALV GTLSQPMIGI QRTMWSISFL EPRPHTTLFF TLLCAANLLG LGAQWVCSTL
250 260 270 280 290 300
VLLKIRQVKK KISKNKLNQN SANRFRKQVI LALNEIIVTG NFKARLTFQF FYPSILCTIS
310 320 330 340 350 360
TFLFFIKPYA FEYLSGWQLV ILHLLWLCNH TCNPFIYAYF NDRMRLTYKE ILTCAAIRYQ
370 380 390 400 410 420
IRKRRSSHPF RMHGRHNVSK RSNAAGMKST RISARSGRTN RDGNFVRNSL QMQSRDFEQL
430 440 450 460 470 480
CEFIMRVNPL YDSSEGWRES SDDEPFQPEF TKELESAHNQ GGSSRFDSER EAKSIVLDLG
490
RQTVEHWVKF AKKASI