Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q6TLI7

Entry ID Method Resolution Chain Position Source
AF-Q6TLI7-F1 Predicted AlphaFoldDB

7 variants for Q6TLI7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3447253966 41 T>I No EVA
rs3446766290 124 V>I No EVA
rs3446766226 127 V>I No EVA
rs3447266586 180 Y>F No EVA
rs3446641145 213 T>S No EVA
rs3434889474 372 R>H No EVA
rs3429894483 407 D>G No EVA

No associated diseases with Q6TLI7

1 regional properties for Q6TLI7

Type Name Position InterPro Accession
domain GPCR, rhodopsin-like, 7TM 23 - 288 IPR017452

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Colocalizes with GAS2L2 at neuronal processes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
postsynapse The part of a synapse that is part of the post-synaptic cell.

5 GO annotations of molecular function

Name Definition
enzyme binding Binding to an enzyme, a protein with catalytic activity.
G protein-coupled adenosine receptor activity Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
identical protein binding Binding to an identical protein or proteins.
lipid binding Binding to a lipid.

16 GO annotations of biological process

Name Definition
adenylate cyclase-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
apoptotic signaling pathway The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
biomineralization The process where mineral crystals are formed and deposited in an organized fashion in a matrix (either cellular or extracellular) by living organisms. This gives rise to inorganic compound-based structures such as skeleton, teeth, ivory, shells, cuticle, and corals as well as bacterial biomineralization products.
eating behavior The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
G protein-coupled adenosine receptor signaling pathway The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
inhibitory postsynaptic potential A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
locomotory behavior The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
negative regulation of alpha-beta T cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.
negative regulation of inflammatory response Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
positive regulation of apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
positive regulation of synaptic transmission, GABAergic Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).
response to amphetamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.
response to inorganic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
response to purine-containing compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus.
synaptic transmission, dopaminergic The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q10042 K01A12.3 Probable G-protein coupled receptor K01A12.3 Caenorhabditis elegans PR
10 20 30 40 50 60
MPTVGSLVYI MVELAIALLA ILGNMLVCWA VWLNSNLQNV TNYFVVSLAA ADIAVGVLAI
70 80 90 100 110 120
PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI DRYIAIRIPL RYNGLVTGTR
130 140 150 160 170 180
AKGVIAVCWV LSFAIGLTPM LGWNNCHHWG EGENQSQGCG EGQVACLFED VVPMNYMVYY
190 200 210 220 230 240
NFFACVLVPL LLMLGVYLRI FLAARRQLKQ METQPLPGER ARSTLQKEVH AAKSLAIIVG
250 260 270 280 290 300
LFALCWLPLH IINCFTFFCP ECPHAPLWLM YPAIILSHFN SVVNPFIYAY RIREFRHTFH
310 320 330 340 350 360
KIIRSHILRR QEPFKAGGTS ARALAAHGSD AEQVSLRLNG HPSGVCPNGS APHPERRPNG
370 380 390 400 410
YALGLVSRAS ARESPGDTGL PDVELLSHEL HGASPESPGL EGPLAQDGAG VS