Q10040

PR
Gene name
C28F5.4
Protein name
Putative zinc protease C28F5.4
Names
Species
Caenorhabditis elegans
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q10040

Entry ID Method Resolution Chain Position Source
AF-Q10040-F1 Predicted AlphaFoldDB

No variants for Q10040

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10040

No associated diseases with Q10040

5 regional properties for Q10040

Type Name Position InterPro Accession
binding_site Peptidase M16, zinc-binding site 58 - 81 IPR001431
domain Peptidase M16, C-terminal 201 - 376 IPR007863-1
domain Peptidase M16, C-terminal 603 - 782 IPR007863-2
domain Peptidase M16, N-terminal 37 - 174 IPR011765
domain Peptidase M16, middle/third domain 410 - 599 IPR032632

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

2 GO annotations of biological process

Name Definition
peptide catabolic process The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
proteolysis involved in protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06010 STE23 A-factor-processing enzyme Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P22817 Ide Insulin-degrading enzyme Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MTKKAKRNIV HKRFDSIVKG SQDTKKYRGL ELTNGLRVLL VSDSKTRVSA VALDVKVGHL
70 80 90 100 110 120
MDPWELPGLA HFCEHMLFLG TAKYPSEREY FKYLAANNGD SNAYTDTDHT NYSFEVRSEK
130 140 150 160 170 180
LYGALDRFAQ FFLDPQFTES ATEREVCAVN CEYLDKVNED FWRCLQVERS LSKPGHDYSK
190 200 210 220 230 240
FAIGNKKTLL EDPRTKGIEP RDVLLDFYKN WYSSDIMTCC IVGKESLDVL ESYLGSFKFD
250 260 270 280 290 300
AIKNTRKERK IWKDSPFGPD QLAKRIEIVP IQNTGQVSIK FPFPDLNGEF LSQPGDYIAH
310 320 330 340 350 360
LIGHEGPGSL LSELKRLGWV ISLEADNHTI ASGFGVFSVT MDLSTEGLEH VDDVIQLVFN
370 380 390 400 410 420
FIGFLKSSGP QKWIHDELAE LNAVDFRFDD VKHTMEKASI LAECLHPKIR KNFETALKTS
430 440 450 460 470 480
HHAFNLPEKN EYIPSKFDQK PREPVKSGYP RLISEDEWIQ VWFKQDNEYN SPKQGIMFAL
490 500 510 520 530 540
TTPLVAKKSK NVVAFKSLDT IIEETYNARL AGLECQFESS SSGVQIRVFG YDEKQSLFAK
550 560 570 580 590 600
HLVNRMANFQ VNRLCFDISF ESLKRTLTNH AFSQPHDLSA HFIDLLVVDN IWSKEQLLAV
610 620 630 640 650 660
CDSVTLEDVH GFAIKMLQAF HMELFVHGNS TEKDTLQLSK ELSDILKSVA PNSRPLKRDE
670 680 690 700 710 720
HNPHRELQLI NGHEHVYRHF QKTHDVGCVE VAFQIGVQST YNNSVNKLLN ELIKNPAYTI
730 740 750 760 770 780
LRTNEALGYN VSTESRLNDG NVYLHVIVQG PESADHVLER IEVFLESARE EIVAMPQEDF
790 800 810 820 830 840
DYQVWAMFKE NPPTLSQCFS MFWSEIHSRQ YNFGRNKEVR GISKRITKEE VINFFDRKIR
850
KGGAERRKLA LGLWKK