Q06010

PR
Gene name
STE23 (YLR389C, L8084.12)
Protein name
A-factor-processing enzyme
Names
Insulin-degrading enzyme homolog
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR389C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

261-336 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q06010

Entry ID Method Resolution Chain Position Source
AF-Q06010-F1 Predicted AlphaFoldDB

19 variants for Q06010

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-902591 24 L>F No SGRP
s12-902330 111 K>E No SGRP
s12-901826 279 D>N No SGRP
s12-901778 295 V>I No SGRP
s12-901759 301 P>L No SGRP
s12-901752 303 M>I No SGRP
s12-901463 400 V>I No SGRP
s12-901058 535 R>S No SGRP
s12-901022 547 D>H No SGRP
s12-900850 604 T>K No SGRP
s12-900812 617 V>L No SGRP
s12-900451 737 T>I No SGRP
s12-900301 787 E>G No SGRP
s12-900280 794 Q>R No SGRP
s12-900124 846 S>N No SGRP
s12-899848 938 A>V No SGRP
s12-899794 956 E>A No SGRP
s12-899732 977 N>D No SGRP
s12-899580 1027 E>D No SGRP

No associated diseases with Q06010

2 regional properties for Q06010

Type Name Position InterPro Accession
domain TonB/TolA, C-terminal 209 - 280 IPR006260
domain TonB, C-terminal 207 - 279 IPR037682

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

4 GO annotations of biological process

Name Definition
peptide catabolic process The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion.
proteolysis involved in protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
response to pheromone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P22817 Ide Insulin-degrading enzyme Drosophila melanogaster (Fruit fly) PR
Q10040 C28F5.4 Putative zinc protease C28F5.4 Caenorhabditis elegans PR
10 20 30 40 50 60
MGVSLLASSS AFVTKPLLTQ LVHLSPISLN FTVRRFKPFT CLSRYYTTNP YNMTSNFKTF
70 80 90 100 110 120
NLDFLKPDLD ERSYRFIELP NKLKALLIQD PKADKAAASL DVNIGAFEDP KNLPGLAHFC
130 140 150 160 170 180
EHLLFMGSEK FPDENEYSSY LSKHGGSSNA YTASQNTNYF FEVNHQHLFG ALDRFSGFFS
190 200 210 220 230 240
CPLFNKDSTD KEINAVNSEN KKNLQNDIWR IYQLDKSLTN TKHPYHKFST GNIETLGTLP
250 260 270 280 290 300
KENGLNVRDE LLKFHKNFYS ANLMKLCILG REDLDTLSDW TYDLFKDVAN NGREVPLYAE
310 320 330 340 350 360
PIMQPEHLQK IIQVRPVKDL KKLEISFTVP DMEEHWESKP PRILSHLIGH EGSGSLLAHL
370 380 390 400 410 420
KKLGWANELS AGGHTVSKGN AFFAVDIDLT DNGLTHYRDV IVLIFQYIEM LKNSLPQKWI
430 440 450 460 470 480
FNELQDISNA TFKFKQAGSP SSTVSSLAKC LEKDYIPVSR ILAMGLLTKY EPDLLTQYTD
490 500 510 520 530 540
ALVPENSRVT LISRSLETDS AEKWYGTAYK VVDYPADLIK NMKSPGLNPA LTLPRPNEFV
550 560 570 580 590 600
STNFKVDKID GIKPLDEPVL LLSDDVSKLW YKKDDRFWQP RGYIYLSFKL PHTHASIINS
610 620 630 640 650 660
MLSTLYTQLA NDALKDVQYD AACADLRISF NKTNQGLAIT ASGFNEKLII LLTRFLQGVN
670 680 690 700 710 720
SFEPKKDRFE ILKDKTIRHL KNLLYEVPYS QMSNYYNAII NERSWSTAEK LQVFEKLTFE
730 740 750 760 770 780
QLINFIPTIY EGVYFETLIH GNIKHEEALE VDSLIKSLIP NNIHNLQVSN NRLRSYLLPK
790 800 810 820 830 840
GKTFRYETAL KDSQNVNSCI QHVTQLDVYS EDLSALSGLF AQLIHEPCFD TLRTKEQLGY
850 860 870 880 890 900
VVFSSSLNNH GTANIRILIQ SEHTTPYLEW RINNFYETFG QVLRDMPEED FEKHKEALCN
910 920 930 940 950 960
SLLQKFKNMA EESARYTAAI YLGDYNFTHR QKKAKLVANI TKQQMIDFYE NYIMSENASK
970 980 990 1000 1010 1020
LILHLKSQVE NKELNENELD TAKYPTGQLI EDVGAFKSTL FVAPVRQPMK DFEISAPPKL
NNSSESE