Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q10025

Entry ID Method Resolution Chain Position Source
AF-Q10025-F1 Predicted AlphaFoldDB

No variants for Q10025

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q10025

No associated diseases with Q10025

No regional properties for Q10025

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q10025

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
ligand-gated sodium channel activity Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

1 GO annotations of biological process

Name Definition
sodium ion transmembrane transport A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F1MJW3 SCNN1G Amiloride-sensitive sodium channel subunit gamma Bos taurus (Bovine) PR
H2QAR5 SCNN1G Amiloride-sensitive sodium channel subunit gamma Pan troglodytes (Chimpanzee) PR
P51170 SCNN1G Amiloride-sensitive sodium channel subunit gamma Homo sapiens (Human) PR
P37088 SCNN1A Amiloride-sensitive sodium channel subunit alpha Homo sapiens (Human) PR
Q61180 Scnn1a Amiloride-sensitive sodium channel subunit alpha Mus musculus (Mouse) PR
P37089 Scnn1a Amiloride-sensitive sodium channel subunit alpha Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MVRMAERLAE NFIPEANQRN ENEPAYSRYK RVGQNRSRLN SRASLGSSMG RRITLIETDS
70 80 90 100 110 120
GVIEVESDKQ FLDAFKDANM DAVHHLNAAS PVTRGLWCMI IIAFVILVLV QCYSQIKLYI
130 140 150 160 170 180
SEPVATNIEA EYPSKISFPT VAICNNNQFR LTYLTGGRIM NRRSKSISGS LLSTGHDVES
190 200 210 220 230 240
VFDTVLRKSW DMDAVKFLRS AAHWKSRMIL GCTWPNGTSC KLSDFKAVWT TTGLCWAINT
250 260 270 280 290 300
DPHNPYEVTG SGEGHGLRLL LNVESYERVD ACTKHFRTKT LPGLKILIYN QTDIPDSSMN
310 320 330 340 350 360
GVNVPSGYSM DIPFKMQHRS KLTGVHCIEE NDEQIEASTD FNNPENIRTC TLRRYMTEVE
370 380 390 400 410 420
NSCHCTLRRA YTSNSTDVKM KACNVDQYFG CAQKAMQRIR EEGTASTCLP PCKSIDYTAW
430 440 450 460 470 480
QDMNRLPQNL MPALIEEQEE DDEDDVEQEE LDENVSFSTV SGGETFSCED SAYLDDKQVM
490 500 510 520 530 540
RIKRDAHRAY EMQARHQEDI FLRSRRLIAR LRNAINSIER YKWGWHYDTF SGVADRLSNL
550 560 570 580 590 600
TCFSNFSERH RDIISILESR PITSEEKKAN QMFFLLDETA FNRNATRYMS VGDLKSRYGD
610 620 630 640 650 660
KVDDVAEEIA VILRIMEKLW HVFMPDSYIR TMTGDFSRMD RIIELMNQYE LNKLQRRAWA
670 680 690 700 710 720
EKMQSRQMKH FFEDDFYESY YQPLIKDLDT TLVKQIDEVE ADWPKVEYYL QRGSAGKTGA
730 740 750 760 770 780
IMFFGDGNKD NRQKFEKLIV EMHECASGKM RKEAGKMLSS FKKSYRELQA AYGKLFKEEL
790 800 810 820 830 840
PDYLENFQFG NKFVGDNFAM VNIFLHRMNL EVWSQDRTYG FWSLACDIGG ALGLFLGASL
850 860 870 880 890 900
LTIIEIVYLC IQYGLCGKRA RNMKCIPMDA LTRQMKKVAT CSCCKKPIEK SREPIYKKKS
910 920 930 940 950 960
QSYQRRFTAD DEDQGDKFRS RASSEESKRR KNIWAQMNDP SGNSTLTPSE IKNFLDQVQR
970 980 990 1000 1010 1020
NSQPPSYHDD HHPEDHYYYN DPNYLTISPP SDRPEDNREG STSGYYSSPR APPQANPRDE
1030 1040 1050 1060
SPIPDTEPIS VSEFSDALAP PLFKTPPRER RTRKEQKIDE EDDDKHSYV