Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for H2QAR5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-H2QAR5-F1 | Predicted | AlphaFoldDB |
No variants for H2QAR5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for H2QAR5 | |||||
No associated diseases with H2QAR5
1 regional properties for H2QAR5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Epithelial sodium channel, conserved site | 325 - 345 | IPR020903 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| sodium channel complex | An ion channel complex through which sodium ions pass. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ligand-gated sodium channel activity | Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| response to stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. |
| sensory perception of taste | The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| F1MJW3 | SCNN1G | Amiloride-sensitive sodium channel subunit gamma | Bos taurus (Bovine) | PR |
| P37088 | SCNN1A | Amiloride-sensitive sodium channel subunit alpha | Homo sapiens (Human) | PR |
| P51170 | SCNN1G | Amiloride-sensitive sodium channel subunit gamma | Homo sapiens (Human) | PR |
| Q61180 | Scnn1a | Amiloride-sensitive sodium channel subunit alpha | Mus musculus (Mouse) | PR |
| P37089 | Scnn1a | Amiloride-sensitive sodium channel subunit alpha | Rattus norvegicus (Rat) | PR |
| Q10025 | del-10 | Degenerin-like protein del-10 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPGEKIKAK | IKKNLPVTGP | QAPTIKELMR | WYCLNTNTHG | CRRIVVSRGR | LRRLLWIGFT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LTAVALILWQ | CALLVFSFYT | VSVSIKVHFR | KLDFPAVTIC | NINPYKYSTV | RHLLADLEQE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TREALKSLYG | FPESRKRREA | ESWSSISEGK | QPRFSHRIPL | LIFDQDEKGK | ARDFFTGRKR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KVGGSIIHKA | SNVMHIESKQ | VVGFQLNFTL | FHHPMHGNCY | TFNNRENETI | LSTSMGGSEY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GLQVILYINE | EEYNPFLVSS | TGAKVIIHRQ | DEYPFVEDVG | TEIETAMVTS | IGMHLTESFK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSEPYSQCTE | DGSDVPIRNI | YNAAYSLQIC | LHSCFQTKMV | EKCGCAQYSQ | PLPPAANYCN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YQQHPNWMYC | YYQLHRAFVQ | EELGCQSVCK | EACSFKEWTL | TTSLAQWPSV | VSEKWLLPVL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TWDQGRQVNK | KLNKTDLAKL | LIFYKDLNQR | SIMESPANSI | EMLLSNFGGQ | LGLWMSCSVV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CVIEIIEVFF | IDFFSIIARR | QWQKAKEWWA | RKQAPPCPEA | PRSPQGQDNP | ALDIDDDLPT |
| 550 | 560 | 570 | 580 | ||
| FNSALHLPPA | LGTQVPGTPP | PKYNTLRLER | AFSNQLTDTQ | MLDEL |