Q0VBZ5

PR
Gene name
JUNB
Protein name
Transcription factor JunB
Names
Transcription factor AP-1 subunit JunB
Species
Bos taurus (Bovine)
KEGG Pathway
bta:514246
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

174-295 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0VBZ5

Entry ID Method Resolution Chain Position Source
AF-Q0VBZ5-F1 Predicted AlphaFoldDB

248 variants for Q0VBZ5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs434616181 5 M>T No EVA
rs459133931 31 D>G No EVA
rs482580181 31 D>H No EVA
rs445500179 33 K>N No EVA
rs459759357 38 S>R No EVA
rs479857921 38 S>R No EVA
rs442901151 43 L>M No EVA
rs474274713 45 D>G No EVA
rs463776526 46 P>A No EVA
rs443553520 49 N>S No EVA
rs451660052 50 L>R No EVA
rs434653001 52 A>E No EVA
rs435287902 63 N>T No EVA
rs469822984 68 Y>F No EVA
rs432825876 74 S>P No EVA
rs432825876 74 S>T No EVA
rs445539159 75 D>V No EVA
rs463981259 75 D>Y No EVA
rs466219285 79 S>P No EVA
rs466219285 79 S>T No EVA
rs449356826 79 S>W No EVA
rs480756102 80 L>P No EVA
rs443709929 84 S>L No EVA
rs441162842 86 E>G No EVA
rs455535794 87 L>V No EVA
rs476440798 88 E>* No EVA
rs456208128 88 E>G No EVA
rs432853578 89 R>S No EVA
rs464013895 90 L>I No EVA
rs453548056 90 L>P No EVA
rs435064717 91 I>L No EVA
rs466258156 91 I>N No EVA
rs480918483 92 V>G No EVA
rs449565219 92 V>L No EVA
rs470386054 94 N>K No EVA
rs450132671 99 I>L No EVA
rs478271173 99 I>S No EVA
rs458145020 100 T>R No EVA
rs441199949 101 T>P No EVA
rs462086007 102 T>A No EVA
rs441895830 103 P>A No EVA
rs456292493 104 T>S No EVA
rs433599826 107 G>R No EVA
rs456003349 109 Y>S No EVA
rs435868038 110 F>I No EVA
rs470397192 111 Y>F No EVA
rs450226839 113 R>P No EVA
rs464610661 119 G>* No EVA
rs447778172 125 G>R No EVA
rs462138242 130 E>A No EVA
rs479045939 130 E>K No EVA
rs447036449 134 G>C No EVA
rs482935575 140 V>A No EVA
rs482935575 140 V>E No EVA
rs439339477 146 L>V No EVA
rs460119223 148 K>E No EVA
rs440048177 149 M>T No EVA
rs474439926 151 H>P No EVA
rs454485455 152 V>A No EVA
rs435899528 153 T>K No EVA
rs476894796 154 P>T No EVA
rs456678028 156 N>T No EVA
rs433403370 157 V>E No EVA
rs464749906 158 S>A No EVA
rs447821641 158 S>F No EVA
rs464749906 158 S>T No EVA
rs434047128 159 L>V No EVA
rs468571924 161 A>P No EVA
rs482993678 162 S>G No EVA
rs462906441 163 G>V No EVA
rs445898371 164 G>A No EVA
rs445898371 164 G>D No EVA
rs445898371 164 G>V No EVA
rs460156745 165 P>R No EVA
rs474691824 166 P>Q No EVA
rs443966951 167 A>P No EVA
rs443966951 167 A>S No EVA
rs456858612 168 G>A No EVA
rs456858612 168 G>E No EVA
rs454293522 169 P>H No EVA
rs454293522 169 P>R No EVA
rs471218594 169 P>S No EVA
rs471218594 169 P>T No EVA
rs468650854 170 G>A No EVA
rs434077976 170 G>R No EVA
rs454943050 172 V>A No EVA
rs469343159 173 Y>C No EVA
rs438031480 173 Y>H No EVA
rs469343159 173 Y>S No EVA
rs445936095 174 A>P No EVA
rs477082517 174 A>V No EVA
rs133605637 175 G>A No EVA
rs133605637 175 G>V No EVA
rs444080602 176 P>R No EVA
rs461096577 176 P>T No EVA
rs458505454 177 E>A No EVA
rs439952450 177 E>D No EVA
rs471257262 178 P>A No EVA
rs475199400 181 V>D No EVA
rs440635734 181 V>F No EVA
rs455054125 182 Y>H No EVA
rs438065570 182 Y>S No EVA
rs469426088 183 T>P No EVA
rs452358883 184 N>H No EVA
rs432263445 184 N>I No EVA
rs432263445 184 N>T No EVA
rs466654531 186 S>T No EVA
rs446694039 187 S>R No EVA
rs481300923 188 Y>D No EVA
rs467524657 188 Y>F No EVA
rs450592614 189 S>A No EVA
rs450592614 189 S>P No EVA
rs458544244 190 P>Q No EVA
rs479403790 191 A>G No EVA
rs438370757 191 A>P No EVA
rs460885107 192 S>P No EVA
rs461482834 193 A>E No EVA
rs475268184 193 A>P No EVA
rs475672432 195 S>P No EVA
rs432396240 197 G>V No EVA
rs473194169 198 A>P No EVA
rs473194169 198 A>S No EVA
rs436263922 199 G>A No EVA
rs436898542 204 T>A No EVA
rs444940735 205 G>E No EVA
rs479440769 206 S>C No EVA
rs459320726 206 S>N No EVA
rs447159200 207 S>A No EVA
rs447159200 207 S>T No EVA
rs461567739 208 Y>C No EVA
rs461567739 208 Y>F No EVA
rs444548328 210 T>A No EVA
rs458918587 211 A>D No EVA
rs458918587 211 A>G No EVA
rs475803972 211 A>P No EVA
rs438843500 212 T>A No EVA
rs473232707 213 I>F No EVA
rs453201795 214 S>C No EVA
rs436307533 214 S>T No EVA
rs457230217 215 Y>F No EVA
rs474067800 215 Y>H No EVA
rs457230217 215 Y>S No EVA
rs437031892 216 L>H No EVA
rs434441619 218 H>P No EVA
rs434441619 218 H>R No EVA
rs479845853 219 A>V No EVA
rs461654817 222 F>C No EVA
rs451168837 224 G>A No EVA
rs482257067 225 G>V No EVA
rs458957436 226 H>P No EVA
rs458957436 226 H>R No EVA
rs479680384 228 A>P No EVA
rs479680384 228 A>S No EVA
rs459755906 230 L>R No EVA
rs442746878 231 G>V No EVA
rs474216999 232 L>R No EVA
rs457207449 233 G>A No EVA
rs471615771 234 R>L No EVA
rs434478686 236 A>D No EVA
rs451486403 236 A>S No EVA
rs451486403 236 A>T No EVA
rs455423922 237 S>P No EVA
rs435216937 238 A>P No EVA
rs469781308 238 A>V No EVA
rs451120275 241 E>* No EVA
rs451120275 241 E>Q No EVA
rs482295763 242 E>K No EVA
rs465413439 243 P>A No EVA
rs459835652 245 T>I No EVA
rs479719104 245 T>P No EVA
rs480703698 246 V>A No EVA
rs480703698 246 V>G No EVA
rs463741335 250 R>S No EVA
rs443563207 251 S>R No EVA
rs471654400 252 R>P No EVA
rs451525062 253 D>Y No EVA
rs455379721 258 V>A No EVA
rs472417330 258 V>L No EVA
rs435251086 262 N>K No EVA
rs455942414 264 E>D No EVA
rs469790052 264 E>K No EVA
rs437468302 265 D>G No EVA
rs465452373 271 V>A No EVA
rs465452373 271 V>E No EVA
rs480104854 279 R>Q No EVA
rs135858113 281 A>G No EVA
rs449314421 282 A>G No EVA
rs480715421 283 T>P No EVA
rs463726688 284 K>Q No EVA
rs478193435 285 C>G No EVA
rs478193435 285 C>S No EVA
rs441130202 286 R>P No EVA
rs472410957 287 K>E No EVA
rs461929644 287 K>N No EVA
rs441710286 288 R>G No EVA
rs476308202 289 K>E No EVA
rs432793894 290 L>P No EVA
rs455980273 290 L>V No EVA
rs470395069 291 E>A No EVA
rs470395069 291 E>G No EVA
rs451918693 292 R>G No EVA
rs466339376 293 I>N No EVA
rs466339376 293 I>T No EVA
rs435046767 293 I>V No EVA
rs435681278 294 A>G No EVA
rs478238016 296 L>P No EVA
rs478238016 296 L>R No EVA
rs450199711 296 L>V No EVA
rs458112593 297 E>G No EVA
rs478922353 298 D>E No EVA
rs447513996 298 D>G No EVA
rs441760786 299 K>N No EVA
rs461930107 299 K>Q No EVA
rs476405759 300 V>A No EVA
rs476405759 300 V>G No EVA
rs439241967 301 K>* No EVA
rs470430838 301 K>N No EVA
rs435086224 303 L>H No EVA
rs472888429 304 K>Q No EVA
rs435824920 305 A>T No EVA
rs450244406 307 N>S No EVA
rs447609550 311 S>C No EVA
rs478953582 313 T>A No EVA
rs482658967 321 V>G No EVA
rs462555088 324 L>H No EVA
rs462555088 324 L>P No EVA
rs439277180 326 Q>K No EVA
rs476865436 326 Q>P No EVA
rs440032897 330 T>A No EVA
rs440032897 330 T>P No EVA
rs440032897 330 T>S No EVA
rs474598356 331 H>P No EVA
rs456045419 332 V>D No EVA
rs442272383 333 S>R No EVA
rs476824099 334 N>I No EVA
rs456695925 335 G>V No EVA
rs433267022 336 C>G No EVA
rs464613024 338 L>P No EVA
rs434012474 339 L>P No EVA
rs454139564 339 L>V No EVA
rs468529971 343 K>M No EVA
rs448391464 343 K>N No EVA
rs482689589 345 H>P No EVA
rs469016920 345 H>Q No EVA
rs445758022 346 A>S No EVA
rs477002677 347 F>V No EVA
rs440075923 348 F>L No EVA
rs440075923 348 F>S No EVA

No associated diseases with Q0VBZ5

2 regional properties for Q0VBZ5

Type Name Position InterPro Accession
domain Basic-leucine zipper domain 266 - 331 IPR004827
domain Jun-like transcription factor 6 - 256 IPR005643

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
transcription factor AP-1 complex A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

14 GO annotations of biological process

Name Definition
cellular response to calcium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
decidualization The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.
embryonic process involved in female pregnancy A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.
labyrinthine layer blood vessel development The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.
osteoblast differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
osteoblast proliferation The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.
osteoclast differentiation The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
osteoclast proliferation The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.
positive regulation of cell differentiation Any process that activates or increases the frequency, rate or extent of cell differentiation.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
regulation of cell population proliferation Any process that modulates the frequency, rate or extent of cell proliferation.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
trophectodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.
vasculogenesis The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P17275 JUNB Transcription factor JunB Homo sapiens (Human) PR
P09450 Junb Transcription factor JunB Mus musculus (Mouse) PR
P24898 Junb Transcription factor JunB Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MCTKMEQPFY HDDSYAAAGY GRTPGGLSLH DYKLLKPSLA LNLSDPYRNL KAPGARGPGP
70 80 90 100 110 120
EGNGGGSYFS SQGSDTGASL KLASSELERL IVPNSNGVIT TTPTPPGQYF YPRGGGSGGG
130 140 150 160 170 180
AGGAGGGVTE EQEGFADGFV KALDDLHKMN HVTPPNVSLG ASGGPPAGPG GVYAGPEPPP
190 200 210 220 230 240
VYTNLSSYSP ASAPSGGAGA AVGTGSSYPT ATISYLPHAP PFAGGHPAQL GLGRGASAFK
250 260 270 280 290 300
EEPQTVPEAR SRDATPPVSP INMEDQERIK VERKRLRNRL AATKCRKRKL ERIARLEDKV
310 320 330 340
KTLKAENAGL SSTAGLLREQ VAQLKQKVMT HVSNGCQLLL GVKGHAF