AiPD: Autoinhibited Protein Database

P17275

Gene name	JUNB
Protein name	Transcription factor JunB
Names	Transcription factor AP-1 subunit JunB
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3726
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

23-156 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

23-156 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P17275

Entry ID	Method	Resolution	Chain	Position	Source
AF-P17275-F1	Predicted				AlphaFoldDB

279 variants for P17275

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA305483810 rs1057444264	8	P>L		No	ClinGen TOPMed
CA9231315 rs373960755	9	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA404247158 rs1568381700	11	H>D		No	ClinGen Ensembl
CA404247164 rs1347227944	11	H>Q		No	ClinGen TOPMed gnomAD
TCGA novel	12	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9231317 rs766066573	12	D>N		No	ClinGen ExAC gnomAD
CA9231319 rs754548911	13	D>G		No	ClinGen ExAC gnomAD
rs752094779 CA9231321	15	Y>F		No	ClinGen ExAC gnomAD
CA9231320 rs780779147	15	Y>H		No	ClinGen ExAC gnomAD
CA404247201 rs1232120106	17	A>G		No	ClinGen gnomAD
CA404247198 rs1205150783	17	A>P		No	ClinGen gnomAD
rs1205150783 CA404247197	17	A>T		No	ClinGen gnomAD
rs377693229 CA9231322	18	T>A		No	ClinGen ExAC TOPMed gnomAD
CA305483830 rs953847426 COSM40208	18	T>M	central_nervous_system [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1245715051 CA404247210	19	G>E		No	ClinGen TOPMed gnomAD
rs1245715051 CA404247212	19	G>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1475565285 CA404247234	23	A>S		No	ClinGen gnomAD
rs1475565285 CA404247232	23	A>T		No	ClinGen gnomAD
CA9231323 rs566143821	24	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA404247264 rs1164060447	27	L>P		No	ClinGen gnomAD
TCGA novel	28	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA305483841 rs866222059	30	H>L		No	ClinGen Ensembl
TCGA novel	30	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404247312 rs1367407948	31	D>G		No	ClinGen gnomAD
CA305483849 rs536479159	32	Y>*		No	ClinGen 1000Genomes ExAC TOPMed
CA305483844 rs1043310256	32	Y>H		No	ClinGen TOPMed
TCGA novel	32	Y>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404247339 rs1422464584	33	K>Q		No	ClinGen gnomAD
rs747275291 CA9231327	34	L>F		No	ClinGen ExAC TOPMed gnomAD
CA9231328 rs768700647	35	L>P		No	ClinGen ExAC TOPMed gnomAD
CA404247382 rs776776576	36	K>N		No	ClinGen ExAC TOPMed gnomAD
CA9231330 rs761795034	37	P>Q		No	ClinGen ExAC gnomAD
rs377194147 CA9231332	38	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs984257736 CA305483858	38	S>I		No	ClinGen Ensembl
CA404247408 rs762774654 CA9231333	38	S>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	40	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766190076 CA9231334	40	A>V		No	ClinGen ExAC TOPMed gnomAD
CA9231336 rs759244188	41	V>A		No	ClinGen ExAC TOPMed gnomAD
rs774085996 CA9231335	41	V>I		No	ClinGen ExAC gnomAD
rs767015453 CA9231337	42	N>D		No	ClinGen ExAC gnomAD
rs765894648 CA9231340 CA404247520	45	D>E		No	ClinGen ExAC TOPMed gnomAD
CA9231339 rs755566344	45	D>N		No	ClinGen ExAC gnomAD
rs1259757621 CA404247556	47	Y>S		No	ClinGen TOPMed
CA9231341 rs202243098	48	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs758936159 CA9231342	49	S>T		No	ClinGen ExAC gnomAD
rs780577573 CA9231343	50	L>P		No	ClinGen ExAC gnomAD
CA404247612 rs1313767820	50	L>V		No	ClinGen TOPMed
rs1215954843 CA404247659	52	A>E		No	ClinGen TOPMed gnomAD
CA404247661 rs1215954843	52	A>G		No	ClinGen TOPMed gnomAD
CA404247670 rs1404267178	53	P>R		No	ClinGen TOPMed
rs570057440 CA9231345	53	P>S		No	ClinGen 1000Genomes ExAC
CA404247679 rs1385480818	54	G>E		No	ClinGen gnomAD
CA404247701 rs1402249326	56	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9231346 rs781257277	56	R>P		No	ClinGen ExAC
CA404247707 rs1320462888	57	G>R		No	ClinGen TOPMed gnomAD
rs748304885 CA9231347	57	G>V		No	ClinGen ExAC TOPMed gnomAD
CA404247726 rs917127281	58	P>H		No	ClinGen TOPMed gnomAD
CA305483884 rs917127281	58	P>R		No	ClinGen TOPMed gnomAD
rs1315876476 CA404247768	62	G>S		No	ClinGen gnomAD
rs1243337013 CA404247799	64	G>V		No	ClinGen gnomAD
rs144512497 CA9231349	67	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9231350 rs749248636	67	S>T		No	ClinGen ExAC TOPMed gnomAD
CA9231351 rs770800888	68	Y>C		No	ClinGen ExAC gnomAD
CA9231352 rs774203546	70	S>P		No	ClinGen ExAC TOPMed gnomAD
CA404247888 rs774203546	70	S>T		No	ClinGen ExAC TOPMed gnomAD
CA404247926 rs1244520205	72	Q>R		No	ClinGen gnomAD
rs367885167 CA9231353	73	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA404247949 rs1186683105	73	G>V		No	ClinGen gnomAD
CA404247980 rs1156709805	75	D>A		No	ClinGen gnomAD
rs1187256679 CA404248008	77	G>C		No	ClinGen gnomAD
CA404248060 rs1418867576	80	L>F		No	ClinGen gnomAD
rs763730409 CA9231357	83	A>V		No	ClinGen ExAC gnomAD
CA404248164 rs1260381083	86	E>K		No	ClinGen TOPMed
CA9231359 rs758977122	88	E>G		No	ClinGen ExAC gnomAD
CA404248239 rs766988061	89	R>H		No	ClinGen ExAC TOPMed gnomAD
rs766988061 CA9231360	89	R>L		No	ClinGen ExAC TOPMed gnomAD
CA9231362 rs372072460	91	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs781514054 CA9231363	93	P>S		No	ClinGen ExAC gnomAD
rs1251089961 CA404248346	95	S>N		No	ClinGen gnomAD
rs748346774 CA9231364	96	N>S		No	ClinGen ExAC gnomAD
rs1250883191 CA404248410	99	I>S		No	ClinGen gnomAD
CA305483933 rs980577138	102	T>M		No	ClinGen TOPMed
rs927787776 CA305483941	104	T>K		No	ClinGen TOPMed
CA404248474 rs1599523145	105	P>H		No	ClinGen Ensembl
rs1464567544 CA404248465	105	P>T		No	ClinGen TOPMed gnomAD
rs1393717100 CA404248493	107	G>A		No	ClinGen gnomAD
CA9231367 rs749301986	107	G>R		No	ClinGen ExAC gnomAD
TCGA novel	108	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404248552 rs1336529156	110	F>L		No	ClinGen TOPMed
rs1306549669 CA404248560	111	Y>F		No	ClinGen gnomAD
CA404248554 rs1466447660	111	Y>N		No	ClinGen TOPMed
rs770925811 CA9231368	112	P>T		No	ClinGen ExAC gnomAD
CA404248582 rs774146698	113	R>C		No	ClinGen ExAC gnomAD
CA404248590 rs1284764179	113	R>L		No	ClinGen gnomAD
CA9231369 rs774146698	113	R>S		No	ClinGen ExAC gnomAD
rs1329014840 CA404248594	114	G>R		No	ClinGen gnomAD
rs893825151 CA305483964	115	G>D		No	ClinGen Ensembl
CA305483965 rs960436516	116	G>D		No	ClinGen TOPMed
CA404248639 rs1251421252	117	S>G		No	ClinGen gnomAD
rs1341377695 CA404248647	117	S>I		No	ClinGen gnomAD
rs1203005432 CA404248657	117	S>R		No	ClinGen gnomAD
CA305483970 rs746632492	118	G>A		No	ClinGen TOPMed
CA404248662 rs1273846175	118	G>S		No	ClinGen gnomAD
CA9231370 rs199665194	119	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1431703781 CA404248697	120	G>S		No	ClinGen gnomAD
rs1198243931 CA404248706	120	G>V		No	ClinGen gnomAD
rs1599523193 CA404248712	121	A>T		No	ClinGen Ensembl
TCGA novel	121	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1431724001 CA404248739	122	G>R		No	ClinGen gnomAD
rs1568381884 CA404248747	122	G>V		No	ClinGen Ensembl
rs1167192798 CA404248762	123	G>D		No	ClinGen gnomAD
CA404248755 rs1446148725	123	G>S		No	ClinGen TOPMed
CA9231373 rs541000941	124	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA404248769 rs541000941	124	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1295700988 CA404248790	125	G>E		No	ClinGen gnomAD
rs1425641451	126	G>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs760427973 CA9231374	126	G>C		No	ClinGen ExAC gnomAD
CA404248797 rs1385933363	126	G>D		No	ClinGen gnomAD
CA404248795 rs760427973	126	G>S		No	ClinGen ExAC gnomAD
rs761390844 CA9231377	129	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1360135665 CA404248868	130	E>*		No	ClinGen gnomAD
rs901459201 CA305483993	133	E>K		No	ClinGen gnomAD
CA404249010 rs1262706824	137	D>E		No	ClinGen gnomAD
CA404249061 rs1186782662	140	V>I		No	ClinGen gnomAD
rs1445806166 CA404249098	142	A>V		No	ClinGen gnomAD
rs1338655988 CA404249137	146	L>M		No	ClinGen TOPMed
TCGA novel	147	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1432201177 CA404249186	149	M>I		No	ClinGen TOPMed gnomAD
rs1390419713 CA404249182	149	M>T		No	ClinGen gnomAD
CA9231385 rs753977029	150	N>K		No	ClinGen ExAC
rs757312121 CA9231386	152	V>L		No	ClinGen ExAC gnomAD
rs552829543 CA305484015	153	T>A		No	ClinGen 1000Genomes TOPMed
CA9231389 rs771999822	153	T>K		No	ClinGen ExAC gnomAD
rs779715555 CA9231390	154	P>H		No	ClinGen ExAC TOPMed gnomAD
rs779715555 CA404249240	154	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1310504842 CA404249234	154	P>T		No	ClinGen gnomAD
CA404249247 rs1261486147	155	P>H		No	ClinGen TOPMed gnomAD
CA404249249 rs1261486147	155	P>R		No	ClinGen TOPMed gnomAD
CA404249261 rs574468971	156	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA404249278 rs1206864789	158	S>F		No	ClinGen gnomAD
rs868043822 CA305484027	159	L>M		No	ClinGen Ensembl
rs983898357 CA305484029	161	A>V		No	ClinGen TOPMed gnomAD
rs1184045320 CA404249310	162	T>A		No	ClinGen gnomAD
rs563477406 CA9231393	162	T>S		No	ClinGen 1000Genomes ExAC gnomAD
CA9231394 rs761448856	164	G>V		No	ClinGen ExAC gnomAD
rs769217729 CA404249325	165	P>A		No	ClinGen ExAC gnomAD
CA305484040 rs769217729	165	P>S		No	ClinGen ExAC gnomAD
CA9231395 rs769217729	165	P>T		No	ClinGen ExAC gnomAD
CA404249341 rs1599523316	167	A>V		No	ClinGen Ensembl
rs1599523322 CA404249350	168	G>A		No	ClinGen Ensembl
CA404249362 rs1406106205	169	P>L		No	ClinGen gnomAD
CA404249357 rs1175755412	169	P>S		No	ClinGen TOPMed gnomAD
CA404249364 rs1449594379 CA404249365	170	G>R		No	ClinGen gnomAD
CA404249376 rs1378385060	171	G>D		No	ClinGen gnomAD
rs772728902 CA9231396	171	G>S		No	ClinGen ExAC
rs1391742278 CA404249382	172	V>F		No	ClinGen gnomAD
TCGA novel	172	V>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	172	V>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs530685477 CA9231397	174	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA305484054 rs972415074	175	G>V		No	ClinGen Ensembl
CA9231398 rs768002938	176	P>L		No	ClinGen ExAC gnomAD
rs1226853530 CA404249449	178	P>T		No	ClinGen TOPMed gnomAD
rs1290476249 CA404249477	181	V>I		No	ClinGen TOPMed
rs1236180660 CA404249538	186	S>T		No	ClinGen gnomAD
rs1483236669 CA404249550	187	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1254489511 CA404249577	189	S>F		No	ClinGen gnomAD
CA305484061 rs950028337	189	S>P		No	ClinGen Ensembl
rs1471823839 CA404249584	190	P>L		No	ClinGen TOPMed gnomAD
rs12151069 CA305484064	191	A>S		No	ClinGen TOPMed gnomAD
rs12151069 CA404249586	191	A>T		No	ClinGen TOPMed gnomAD
rs1429597994 CA404249591	191	A>V		No	ClinGen gnomAD
CA404249612 rs1173408858	193	A>V		No	ClinGen gnomAD
CA404249628 rs1241163103	195	S>A		No	ClinGen TOPMed
rs980409552 CA305484072	196	G>R		No	ClinGen Ensembl
rs757464520 CA9231403	197	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1348329488 CA404249670	198	A>G		No	ClinGen gnomAD
CA404249692 rs1287919541	200	A>P		No	ClinGen gnomAD
CA404249690 rs1287919541	200	A>T		No	ClinGen gnomAD
CA404249719 rs1368598215	202	V>I		No	ClinGen gnomAD
CA305484085 rs867100888	203	G>W		No	ClinGen Ensembl
CA9231406 CA305484096 rs758331384	205	G>R		No	ClinGen ExAC TOPMed gnomAD
rs17881800 CA404249786	206	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA404249807 rs1277405323	207	S>L		No	ClinGen gnomAD
CA404249843 rs1181936871	210	T>A		No	ClinGen gnomAD
rs1599523447 CA404249857	211	T>A		No	ClinGen Ensembl
CA9231408 rs746846753	211	T>N		No	ClinGen ExAC gnomAD
rs754784488 CA9231409	212	T>A		No	ClinGen ExAC gnomAD
rs1188943207 CA404249879	213	I>V		No	ClinGen gnomAD
CA404249935 rs1428604281	216	L>F		No	ClinGen gnomAD
rs1420005431 CA404249937	216	L>H		No	ClinGen TOPMed
rs1170334932 CA404249952	217	P>L		No	ClinGen gnomAD
CA9231412 rs769429431	218	H>Q		No	ClinGen ExAC gnomAD
rs747823735 CA9231411	218	H>R		No	ClinGen ExAC TOPMed gnomAD
rs893934130 CA305484133	219	A>T		No	ClinGen TOPMed gnomAD
CA305484139 rs1002071250	219	A>V		No	ClinGen TOPMed gnomAD
rs1366919180 CA404249987	220	P>L		No	ClinGen gnomAD
rs373004953 CA9231413	220	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs772513594 CA9231415	221	P>L		No	ClinGen ExAC gnomAD
rs748828172 CA9231414	221	P>S		No	ClinGen ExAC TOPMed gnomAD
rs775954192 CA9231417	223	A>D		No	ClinGen ExAC gnomAD
rs775954192 CA9231416	223	A>V		No	ClinGen ExAC gnomAD
CA9231419 rs776935129	224	G>S		No	ClinGen ExAC gnomAD
rs111454909 CA305484185	226	H>P		No	ClinGen Ensembl
rs765490204 CA9231421	227	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA404250127 rs1217424977	227	P>S		No	ClinGen TOPMed
CA404250150 rs1448833943	228	A>E		No	ClinGen TOPMed gnomAD
rs766454731 CA9231424	228	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1448833943 CA404250155	228	A>V		No	ClinGen TOPMed gnomAD
rs1346165904 CA404250188	230	L>P		No	ClinGen TOPMed gnomAD
CA404250185 rs1346165904	230	L>R		No	ClinGen TOPMed gnomAD
VAR_021081 rs17880705 CA9231425	230	L>V		No	ClinGen UniProt 1000Genomes ExAC dbSNP gnomAD
CA404250221 rs1403399172	232	L>S		No	ClinGen gnomAD
rs1285525204 CA404250250	234	R>H		No	ClinGen TOPMed
rs747907900 CA9231428	235	G>D		No	ClinGen ExAC gnomAD
rs113612911 CA9231427	235	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1322696442 CA404250270	236	A>S		No	ClinGen gnomAD
rs1322696442 CA404250272	236	A>T		No	ClinGen gnomAD
rs1228380424 CA404250336	238	T>S		No	ClinGen gnomAD
rs1358826438 CA404250346	239	F>L		No	ClinGen gnomAD
rs1210022588 CA404250436	243	P>L		No	ClinGen TOPMed gnomAD
rs777470976 CA9231430	243	P>S		No	ClinGen ExAC gnomAD
TCGA novel	244	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404250463 rs1430795359	246	V>A		No	ClinGen TOPMed
CA404250458 rs1245739918	246	V>M		No	ClinGen gnomAD
TCGA novel	247	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404250493 rs1464060530	249	A>G		No	ClinGen gnomAD
rs1239168473 CA404250502	250	R>C		No	ClinGen gnomAD
CA9231431 rs377604283	250	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA404250508 COSM48457 rs377604283	250	R>L	lung large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
TCGA novel	252	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404250580 rs1599523557	254	A>T		No	ClinGen Ensembl
CA404250603 rs1161449953	255	T>M		No	ClinGen gnomAD
CA404250639 rs1599523564	258	V>A		No	ClinGen Ensembl
CA9231433 rs773814712	258	V>L		No	ClinGen ExAC gnomAD
TCGA novel	259	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404250678 rs1284014450	261	I>L		No	ClinGen TOPMed gnomAD
CA404250680 rs1284014450	261	I>V		No	ClinGen TOPMed gnomAD
CA404250727 rs1329420658	263	M>I		No	ClinGen TOPMed gnomAD
rs1229911819 CA404250737	264	E>K		No	ClinGen gnomAD
rs998464360 CA305484256	268	R>L		No	ClinGen Ensembl
CA404250890 rs1327823383	272	E>K		No	ClinGen gnomAD
rs1200560358 CA404250920	273	R>C		No	ClinGen gnomAD
CA404250944 rs1258158000	275	R>W		No	ClinGen TOPMed gnomAD
TCGA novel	277	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374496104 CA9231436	279	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA404251017 rs1215354308	279	R>P		No	ClinGen TOPMed
rs202032423 CA9231438	281	A>G		No	ClinGen ExAC gnomAD
rs202032423 CA404251060	281	A>V		No	ClinGen ExAC gnomAD
CA404251074 rs1410069842	282	A>G		No	ClinGen gnomAD
CA404251070 rs1599523608	282	A>S		No	ClinGen Ensembl
CA404251141 rs1599523620	285	C>G		No	ClinGen Ensembl
rs1173281612 CA404251162	286	R>W		No	ClinGen gnomAD
CA404251276 rs1333908278	292	R>H		No	ClinGen gnomAD
CA404251278 rs1333908278	292	R>P		No	ClinGen gnomAD
CA404251347 rs1222033802	297	E>D		No	ClinGen TOPMed
CA404251416 rs1286020998	302	T>M		No	ClinGen gnomAD
TCGA novel	304	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770362511 CA9231440	305	A>T		No	ClinGen ExAC gnomAD
CA404251480 rs1257318184	308	A>T		No	ClinGen gnomAD
CA404251518 rs1199753940	311	S>L		No	ClinGen gnomAD
CA404251526 rs1483889136	312	S>N		No	ClinGen gnomAD
rs1599523656 CA404251532	313	T>P		No	ClinGen Ensembl
TCGA novel	314	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9231444 rs767556313	314	A>V		No	ClinGen ExAC gnomAD
CA404251558 rs1199666124	315	G>S		No	ClinGen gnomAD
CA404251592 rs1173518782	318	R>W		No	ClinGen gnomAD
rs755915436 CA9231446	319	E>D		No	ClinGen ExAC gnomAD
rs1599523681 CA404251662	324	L>F		No	ClinGen Ensembl
rs1568382132 CA404251695	326	Q>H		No	ClinGen Ensembl
rs753562214 CA9231448	329	M>T		No	ClinGen ExAC gnomAD
CA9231449 rs756858322	330	T>S		No	ClinGen ExAC gnomAD
CA404251773 rs1302978545	332	V>I		No	ClinGen TOPMed gnomAD
rs1302978545 CA404251771	332	V>L		No	ClinGen TOPMed gnomAD
TCGA novel	335	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA305484334 rs201669552	337	Q>H		No	ClinGen Ensembl
rs566081553 CA305484336	340	L>F		No	ClinGen 1000Genomes
CA9231450 rs778411292	341	G>E		No	ClinGen ExAC gnomAD
rs1599523705 CA404251953	342	V>G		No	ClinGen Ensembl
rs745319469 CA9231451	346	A>T		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with P17275

2 regional properties for P17275

Type	Name	Position	InterPro Accession
domain	Basic-leucine zipper domain	266 - 331	IPR004827
domain	Jun-like transcription factor	6 - 256	IPR005643

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase II transcription regulator complex	A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
transcription factor AP-1 complex	A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes.
transcription regulator complex	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

5 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

17 GO annotations of biological process

Name	Definition
cellular response to calcium ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
decidualization	The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.
embryonic process involved in female pregnancy	A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.
integrated stress response signaling	The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.
labyrinthine layer blood vessel development	The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.
osteoblast differentiation	The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
osteoblast proliferation	The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.
osteoclast differentiation	The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
osteoclast proliferation	The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.
positive regulation of cell differentiation	Any process that activates or increases the frequency, rate or extent of cell differentiation.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.
regulation of cell population proliferation	Any process that modulates the frequency, rate or extent of cell proliferation.
regulation of T-helper 17 cell differentiation	Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
trophectodermal cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.
vasculogenesis	The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0VBZ5	JUNB	Transcription factor JunB	Bos taurus (Bovine)	PR
P09450	Junb	Transcription factor JunB	Mus musculus (Mouse)	PR
P24898	Junb	Transcription factor JunB	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MCTKMEQPFY	HDDSYTATGY	GRAPGGLSLH	DYKLLKPSLA	VNLADPYRSL	KAPGARGPGP
70	80	90	100	110	120
EGGGGGSYFS	GQGSDTGASL	KLASSELERL	IVPNSNGVIT	TTPTPPGQYF	YPRGGGSGGG
130	140	150	160	170	180
AGGAGGGVTE	EQEGFADGFV	KALDDLHKMN	HVTPPNVSLG	ATGGPPAGPG	GVYAGPEPPP
190	200	210	220	230	240
VYTNLSSYSP	ASASSGGAGA	AVGTGSSYPT	TTISYLPHAP	PFAGGHPAQL	GLGRGASTFK
250	260	270	280	290	300
EEPQTVPEAR	SRDATPPVSP	INMEDQERIK	VERKRLRNRL	AATKCRKRKL	ERIARLEDKV
310	320	330	340
KTLKAENAGL	SSTAGLLREQ	VAQLKQKVMT	HVSNGCQLLL	GVKGHAF