Q0P5I0

PR
Gene name
MEN1
Protein name
Menin
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:539431
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

355-610 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0P5I0

Entry ID Method Resolution Chain Position Source
AF-Q0P5I0-F1 Predicted AlphaFoldDB

183 variants for Q0P5I0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs445252949 5 A>V No EVA
rs459868218 8 K>T No EVA
rs441345549 11 F>C No EVA
rs474343482 12 P>A No EVA
rs474343482 12 P>T No EVA
rs462272755 18 D>N No EVA
rs442424050 25 A>D No EVA
rs475358751 34 L>M No EVA
rs457030250 41 L>M No EVA
rs471626868 43 F>L No EVA
rs453153559 50 V>G No EVA
rs434559052 58 V>A No EVA
rs467719285 64 Q>K No EVA
rs455583032 77 Y>H No EVA
rs437199472 78 F>I No EVA
rs470135463 84 S>P No EVA
rs445350353 92 R>P No EVA
rs478378724 93 F>S No EVA
rs478378724 93 F>Y No EVA
rs466086690 94 T>I No EVA
rs480618805 96 Q>E No EVA
rs462283369 97 I>F No EVA
rs443851572 97 I>T No EVA
rs463287104 99 G>V No EVA
rs438359173 101 V>F No EVA
rs453023908 102 D>A No EVA
rs441049588 104 S>P No EVA
rs473953709 105 L>P No EVA
rs455646293 106 Y>N No EVA
rs437053031 106 Y>S No EVA
rs470077250 107 P>R No EVA
rs433160311 109 E>G No EVA
rs466149784 111 G>A No EVA
rs466149784 111 G>V No EVA
rs480629361 112 V>A No EVA
rs468569463 113 S>P No EVA
rs458430632 126 W>R No EVA
rs444841884 128 S>T No EVA
rs477753127 129 L>I No EVA
rs459453553 130 S>G No EVA
rs474015250 135 K>E No EVA
rs443397850 136 D>E No EVA
rs476562849 137 R>H No EVA
rs451578557 139 H>Y No EVA
rs478607115 154 S>R No EVA
rs460287267 161 V>G No EVA
rs441834870 165 C>W No EVA
rs481501132 170 L>I No EVA
rs462990256 174 H>L No EVA
rs462990256 174 H>P No EVA
rs444376660 180 D>E No EVA
rs452627620 217 E>D No EVA
rs443530707 254 L>V No EVA
rs458902726 267 L>P No EVA
rs446842647 269 D>E No EVA
rs461431560 272 H>N No EVA
rs440958879 273 L>R No EVA
rs436201488 276 Y>C No EVA
rs465248294 287 E>D No EVA
rs432274314 287 E>G No EVA
rs446901893 292 T>S No EVA
rs479802420 293 P>A No EVA
rs473505147 296 P>S No EVA
rs467872578 299 L>H No EVA
rs449246799 301 L>H No EVA
rs463951337 302 Y>S No EVA
rs876059591 319 Y>S No EVA
rs134622482 344 T>P No EVA
rs459441395 347 V>D No EVA
rs475184278 351 Y>F No EVA
rs462966354 352 N>D No EVA
rs444658193 355 R>C No EVA
rs452850963 357 D>A No EVA
rs434294787 358 E>A No EVA
rs473677669 359 E>D No EVA
rs453732350 360 I>S No EVA
rs468296870 361 Y>S No EVA
rs449660596 363 E>* No EVA
rs464163272 363 E>D No EVA
rs437771272 363 E>G No EVA
rs449660596 363 E>K No EVA
rs437771272 363 E>V No EVA
rs478747894 365 F>L No EVA
rs460401162 366 E>K No EVA
rs481437671 367 V>A No EVA
rs481437671 367 V>G No EVA
rs448473341 367 V>I No EVA
rs448473341 367 V>L No EVA
rs463076369 368 A>P No EVA
rs471066178 369 N>K No EVA
rs459175482 370 D>A No EVA
rs440634441 370 D>E No EVA
rs459175482 370 D>G No EVA
rs459175482 370 D>V No EVA
rs473772031 371 V>L No EVA
rs435181637 372 I>L No EVA
rs474573711 372 I>N No EVA
rs474573711 372 I>T No EVA
rs437683186 373 P>T No EVA
rs464075186 374 N>H No EVA
rs445845869 374 N>T No EVA
rs466900175 375 L>R No EVA
rs448251168 377 K>T No EVA
rs481485704 379 A>P No EVA
rs462941740 380 A>S No EVA
rs450906907 381 S>G No EVA
rs477540550 381 S>I No EVA
rs440642827 382 L>M No EVA
rs480027068 382 L>R No EVA
rs443065569 383 L>V No EVA
rs476127528 386 G>C No EVA
rs456009063 388 E>A No EVA
rs456009063 388 E>V No EVA
rs443986949 389 R>G No EVA
rs433784434 392 E>* No EVA
rs466699912 392 E>G No EVA
rs454693876 394 T>P No EVA
rs437294530 397 T>P No EVA
rs470103475 405 Q>R No EVA
rs445453326 406 D>G No EVA
rs433303600 407 P>Q No EVA
rs466437458 410 F>C No EVA
rs447922812 410 F>L No EVA
rs479474702 427 S>R No EVA
rs448883308 429 T>P No EVA
rs481955803 431 V>M No EVA
rs438619777 432 L>M No EVA
rs477955795 432 L>P No EVA
rs459609741 433 H>P No EVA
rs441124861 433 H>Q No EVA
rs474092524 435 G>V No EVA
rs455761174 438 T>S No EVA
rs443586844 439 F>V No EVA
rs476517839 442 Q>* No EVA
rs451655385 443 S>T No EVA
rs433367475 444 L>I No EVA
rs466354753 444 L>P No EVA
rs435919289 445 G>C No EVA
rs435919289 445 G>S No EVA
rs468838043 448 E>V No EVA
rs471282136 452 R>W No EVA
rs451367915 453 Q>* No EVA
rs465891088 469 E>V No EVA
rs447265065 481 R>G No EVA
rs468232461 486 E>A No EVA
rs449774071 486 E>D No EVA
rs468232461 486 E>G No EVA
rs482763073 487 S>T No EVA
rs457874704 487 S>Y No EVA
rs446029143 488 K>Q No EVA
rs460668680 489 P>A No EVA
rs475085395 490 E>G No EVA
rs442064169 490 E>Q No EVA
rs463193756 491 E>A No EVA
rs463193756 491 E>G No EVA
rs444642171 492 P>A No EVA
rs444642171 492 P>T No EVA
rs439205146 494 P>A No EVA
rs472147596 495 P>A No EVA
rs468093379 498 P>A No EVA
rs464301969 500 L>P No EVA
rs437707484 500 L>V No EVA
rs479077663 501 D>E No EVA
rs445858500 501 D>G No EVA
rs463007612 505 G>A No EVA
rs473710489 511 V>G No EVA
rs440724078 511 V>L No EVA
rs453682051 512 P>A No EVA
rs441562238 514 P>A No EVA
rs441562238 514 P>T No EVA
rs474509595 516 R>L No EVA
rs456033659 518 P>A No EVA
rs464295079 524 G>R No EVA
rs452260407 530 E>D No EVA
rs466887692 533 S>R No EVA
rs448389936 534 A>T No EVA
rs481374447 534 A>V No EVA
rs450992289 535 A>S No EVA
rs459117651 546 P>T No EVA
rs480217159 551 L>R No EVA
rs461608461 553 F>C No EVA
rs441574446 555 S>R No EVA
rs462503981 592 V>G No EVA

No associated diseases with Q0P5I0

No regional properties for Q0P5I0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q0P5I0

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cleavage furrow The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
histone methyltransferase complex A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.
MLL1 complex A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5.
nuclear matrix The dense fibrillar network lying on the inner side of the nuclear membrane.
transcription repressor complex A protein complex that possesses activity that prevents or downregulates transcription.

8 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
four-way junction DNA binding Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
phosphoprotein binding Binding to a phosphorylated protein.
protein N-terminus binding Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
protein-macromolecule adaptor activity The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
R-SMAD binding Binding to a receptor-regulated SMAD signaling protein.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
Y-form DNA binding Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end.

19 GO annotations of biological process

Name Definition
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone H3-K4 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
negative regulation of cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of cyclin-dependent protein serine/threonine kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
negative regulation of DNA-binding transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
negative regulation of JNK cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
negative regulation of osteoblast differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.
negative regulation of telomerase activity Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
osteoblast development The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.
positive regulation of protein binding Any process that activates or increases the frequency, rate or extent of protein binding.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of transforming growth factor beta receptor signaling pathway Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to gamma radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
response to UV Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2SXS5 MEN1 Menin Canis lupus familiaris (Dog) (Canis familiaris) PR
O00255 MEN1 Menin Homo sapiens (Human) PR
O88559 Men1 Menin Mus musculus (Mouse) PR
Q9WVR8 Men1 Menin Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE
70 80 90 100 110 120
LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK
130 140 150 160 170 180
VSDVIWNSLS RSYFKDRAHI QSLFSFITGT KLDSSGVAFA VVGACQALGL RDVHLALSED
190 200 210 220 230 240
HAWVVFGPNG EQTAEVTWHG KGNEDRRGQT VNAGVAERSW LYLKGSYMRC DRKMEVAFMV
250 260 270 280 290 300
CAINPSIDLH TDSLELLQLQ QKLLWLLYDL GHLERYPMAL GNLADLEELE PTPGRPDPLT
310 320 330 340 350 360
LYHKGIASAK TYYRDEHIYP YMYLAGYHCR NRNVREALQA WADTATVIQD YNYCREDEEI
370 380 390 400 410 420
YKEFFEVAND VIPNLLKEAA SLLEAGEERP GEQTQGTQSQ GSALQDPECF AHLLRFYDGI
430 440 450 460 470 480
CKWEEGSPTP VLHVGWATFL VQSLGRFEGQ VRQKVRIVSR EAEAAEAEEP WGEEAREGRR
490 500 510 520 530 540
RGPRRESKPE EPPPPKKPAL DKGPGAGQGA VPGPPRKPPG TVPGTARGAE GGSAAPVPAP
550 560 570 580 590 600
AASPPPEGPV LTFQSEKMKG MKELLVATKI NSSAIKLQLT AQSQVQMKKQ KVSTPSDYTL
SFLKRQRKGL