A2SXS5
Gene name |
MEN1 |
Protein name |
Menin |
Names |
|
Species |
Canis lupus familiaris (Dog) (Canis familiaris) |
KEGG Pathway |
cfa:483758 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2SXS5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2SXS5-F1 | Predicted | AlphaFoldDB |
No variants for A2SXS5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2SXS5 | |||||
No associated diseases with A2SXS5
No regional properties for A2SXS5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A2SXS5 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| histone methyltransferase complex | A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
| Y-form DNA binding | Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| negative regulation of cell cycle | Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. |
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLKAAQKTL | FPLRSIDDVV | RLFAAELGRE | EPDLVLLSLV | LGFVEHFLAV | NRVIPTNVPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LTFQPSPAPD | PPGGLTYFPV | ADLSIIAALY | ARFTAQIRGA | VDLSLYPREG | GVSSRELVKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VSDVIWNSLS | RSYFKDRAHI | QSLFSFITGW | SPTGTKLDSS | GVAFAVVGAC | QALGLRDVHL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ALSEDHAWVV | FGPNGEQTAE | VTWHGKGNED | RRGQTVNAGV | AERSWLYLKG | SYMRCDRKME |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VAFMVCAINP | SIDLHTDSLE | LLQLQQKLLW | LLYDLGHLER | YPMALGNLAD | LEELEPTPGR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PDPLTLYHKG | IASAKTYYRD | EHIYPYMYLA | GYHCRNRNVR | EALQAWADTA | TVIQDYNYCR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EDEEIYKEFF | EVANDVIPNL | LKEAASLLEA | GEERPGEQTQ | GVQSQGSALQ | DPECFAHLLR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FYDGICKWEE | GSPTPVLHVG | WATFLVQSLG | RFEGQVRQKV | RIVSREAEAA | EAEELWGEEA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| REGRRRGPRR | ESKPEEPPPP | KKPALDKGPG | GGQGAMSGPP | RKPPGTVPGT | ARGPEGGSTA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PAPAPAASPP | PEGPVLTFQS | EKMKGMKELL | VATKINSSAI | KLQLTAQSQV | QMKKQKVSTP |
| 610 | |||||
| SDYTLSFLKR | QRKGL |