Q08BI9

PR
Gene name
mcu (zgc:153607)
Protein name
Calcium uniporter protein, mitochondrial
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:768182
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-79 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q08BI9

Entry ID Method Resolution Chain Position Source
AF-Q08BI9-F1 Predicted AlphaFoldDB

No variants for Q08BI9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q08BI9

No associated diseases with Q08BI9

2 regional properties for Q08BI9

Type Name Position InterPro Accession
domain B3 DNA binding domain 79 - 172 IPR003340-1
domain B3 DNA binding domain 576 - 671 IPR003340-2

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
calcium channel complex An ion channel complex through which calcium ions pass.
integral component of mitochondrial inner membrane The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
uniplex complex A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.

3 GO annotations of molecular function

Name Definition
calcium channel activity Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
identical protein binding Binding to an identical protein or proteins.
uniporter activity Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species.

12 GO annotations of biological process

Name Definition
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
calcium import into the mitochondrion A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix.
calcium-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
chordate embryonic development The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
convergent extension involved in gastrulation The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
glucose homeostasis Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
mitochondrial calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
mitochondrial calcium ion transmembrane transport The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
positive regulation of insulin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
positive regulation of mitochondrial calcium ion concentration Any process that increases the concentration of calcium ions in mitochondria.
protein complex oligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
regulation of heart contraction Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NE86 MCU Calcium uniporter protein, mitochondrial Homo sapiens (Human) PR
O64823 At2g23790 Calcium uniporter protein 2, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
F4I111 At1g09575 Calcium uniporter protein 6, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAAKVCRSVL LLSRSSGAVA SSAYPAFGVS SQRHQGTKTE ALSMSLGGHQ TVRRAHGLRT
70 80 90 100 110 120
GGRCALFCHP SATLTAQGWK GSPSWQVQRL LCSPAAEDVS VVYQNGLPVI SVRLPSRRER
130 140 150 160 170 180
CQFTLKPLSD TVGVFLQQLQ AEDRGIDRVT IYSADGARIA SSTGIDILLM DNFKLVINDT
190 200 210 220 230 240
SYLVQPPRRD LLPHEDGERL NDVKILVQQL YTTLRIEEHQ LNKERELIGR LEDLNSQLQP
250 260 270 280 290 300
LEKVKEELSK KAERRTTWVL WGGMAYMATQ FGILARLTWW EYSWDIMEPV TYFITYGTAM
310 320 330 340 350 360
AMYAYFVLTR QEYLYPDARD RQYLLFFHRG AKRTRFDIEK YNKLKDAIAE AELDLKRLRD
370
PLQLNLPIQQ IDTSKD