F4I111
Gene name |
At1g09575 (F14J9.24) |
Protein name |
Calcium uniporter protein 6, mitochondrial |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G09575 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4I111
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4I111-F1 | Predicted | AlphaFoldDB |
24 variants for F4I111
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_3102811_T_A | 8 | R>W | No | 1000Genomes | |
| ENSVATH10848952 | 9 | R>C | No | 1000Genomes | |
| tmp_1_3102804_G_T | 10 | T>K | No | 1000Genomes | |
| ENSVATH10848951 | 14 | N>S | No | 1000Genomes | |
| tmp_1_3102786_A_G | 16 | I>T | No | 1000Genomes | |
| ENSVATH10848949 | 26 | G>S | No | 1000Genomes | |
| ENSVATH00013743 | 27 | H>N | No | 1000Genomes | |
| ENSVATH04545244 | 33 | C>Y | No | 1000Genomes | |
| tmp_1_3102733_C_T | 34 | V>I | No | 1000Genomes | |
| tmp_1_3102727_C_A | 36 | V>F | No | 1000Genomes | |
| tmp_1_3102710_C_A,CG | 41 | E>D | No | 1000Genomes | |
| ENSVATH04545242 | 41 | E>V | No | 1000Genomes | |
| ENSVATH10848947 | 42 | D>N | No | 1000Genomes | |
| ENSVATH04545239 | 48 | K>I | No | 1000Genomes | |
| ENSVATH04545238 | 64 | V>L | No | 1000Genomes | |
| ENSVATH04545237 | 74 | V>M | No | 1000Genomes | |
| tmp_1_3102598_C_A | 79 | V>F | No | 1000Genomes | |
| tmp_1_3102549_G_C | 95 | A>G | No | 1000Genomes | |
| ENSVATH00013740 | 95 | A>T | No | 1000Genomes | |
| tmp_1_3102495_A_G | 113 | V>A | No | 1000Genomes | |
| ENSVATH00013737 | 139 | D>E | No | 1000Genomes | |
| tmp_1_3102276_T_A | 152 | N>Y | No | 1000Genomes | |
| tmp_1_3102183_G_C | 183 | Q>E | No | 1000Genomes | |
| tmp_1_3101975_T_A | 252 | E>V | No | 1000Genomes |
No associated diseases with F4I111
1 regional properties for F4I111
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Calcium uniporter protein, C-terminal | 99 - 257 | IPR006769 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of mitochondrial inner membrane | The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| uniplex complex | A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| uniporter activity | Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium import into the mitochondrion | A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix. |
| mitochondrial calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8NE86 | MCU | Calcium uniporter protein, mitochondrial | Homo sapiens (Human) | PR |
| O64823 | At2g23790 | Calcium uniporter protein 2, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q08BI9 | mcu | Calcium uniporter protein, mitochondrial | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWSMGLIRRT | AMSNAIRASS | QRTWLGHGGL | RSCVTVKTPS | EDEEEKKKEI | TIAEAKKLMR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVNVEDMKKK | LVGVADRDVV | SYSTLLEASQ | GMGIARSPDE | AHVFARVLDD | AGVVLIFRDK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VYLHPDKVVD | LIRRAMPLDQ | NPEEDQIKEE | FNKLRIMKEE | IDVLAHRQVR | KILWCGLATS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MVQIGLFFRL | TFWEFSWDVM | EPITFFATAT | GIIVGYAYFL | MTSRDPTYQD | FMKRLFLSRQ |
| 250 | 260 | 270 | 280 | 290 | |
| RKLLKSHKFD | CERFKELERL | FKMTSSCHAA | ASIRNRVGLE | LDLEDALQSR | RD |