O64823
Gene name |
At2g23790 (F27L4.3) |
Protein name |
Calcium uniporter protein 2, mitochondrial |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G23790 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O64823
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O64823-F1 | Predicted | AlphaFoldDB |
34 variants for O64823
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_10127447_C_G | 3 | M>I | No | 1000Genomes | |
| ENSVATH01877582 | 6 | L>F | No | 1000Genomes | |
| tmp_2_10127389_T_A | 23 | M>L | No | 1000Genomes | |
| ENSVATH00243898 | 46 | T>A | No | 1000Genomes | |
| tmp_2_10127308_G_C | 50 | P>A | No | 1000Genomes | |
| tmp_2_10127292_A_C | 55 | L>W | No | 1000Genomes | |
| ENSVATH00243897 | 62 | M>T | No | 1000Genomes | |
| ENSVATH14539592 | 76 | M>I | No | 1000Genomes | |
| tmp_2_10127226_G_C | 77 | P>R | No | 1000Genomes | |
| ENSVATH05570011 | 81 | S>I | No | 1000Genomes | |
| tmp_2_10127202_T_C | 85 | K>R | No | 1000Genomes | |
| ENSVATH00243896 | 88 | E>Q | No | 1000Genomes | |
| ENSVATH01877579 | 102 | S>A | No | 1000Genomes | |
| ENSVATH05570010 | 102 | S>F | No | 1000Genomes | |
| tmp_2_10127146_G_C | 104 | P>A | No | 1000Genomes | |
| ENSVATH05570008 | 109 | S>I | No | 1000Genomes | |
| ENSVATH05570007 | 118 | L>M | No | 1000Genomes | |
| ENSVATH05570005 | 120 | R>K | No | 1000Genomes | |
| tmp_2_10127092_C_T | 122 | A>T | No | 1000Genomes | |
| tmp_2_10127087_C_A | 123 | Q>H | No | 1000Genomes | |
| tmp_2_10127038_G_T | 140 | P>T | No | 1000Genomes | |
| ENSVATH05570004 | 150 | E>K | No | 1000Genomes | |
| ENSVATH05570003 | 156 | D>Y | No | 1000Genomes | |
| ENSVATH13359738 | 161 | I>F | No | 1000Genomes | |
| tmp_2_10126107_T_C | 199 | H>R | No | 1000Genomes | |
| ENSVATH01877565 | 200 | N>H | No | 1000Genomes | |
| ENSVATH13359718 | 212 | L>R | No | 1000Genomes | |
| ENSVATH05569988 | 222 | K>E | No | 1000Genomes | |
| tmp_2_10126018_T_C | 229 | K>E | No | 1000Genomes | |
| tmp_2_10125780_T_A | 308 | D>V | No | 1000Genomes | |
| ENSVATH01877556 | 308 | D>Y | No | 1000Genomes | |
| ENSVATH05569987 | 309 | L>V | No | 1000Genomes | |
| ENSVATH14539585 | 310 | E>D | No | 1000Genomes | |
| tmp_2_10125741_G_T | 321 | S>Y | No | 1000Genomes |
No associated diseases with O64823
1 regional properties for O64823
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Calcium uniporter protein, C-terminal | 156 - 315 | IPR006769 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of mitochondrial inner membrane | The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| uniplex complex | A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium channel activity | Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| uniporter activity | Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium import into the mitochondrion | A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix. |
| mitochondrial calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8NE86 | MCU | Calcium uniporter protein, mitochondrial | Homo sapiens (Human) | PR |
| F4I111 | At1g09575 | Calcium uniporter protein 6, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q08BI9 | mcu | Calcium uniporter protein, mitochondrial | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAMRKLLSKK | LFNITNVASQ | SLMNCRISSS | SLAVRTRVPN | DSTDTTKIAP | EPGDLAMSRR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FMHNSAMIRP | AEIMQMPVGE | SLIEKLREID | GSKDRIRLDG | LSPPERETSL | TVADTKKLLR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AAQIEIVKSK | LRETGRSWMP | YKEFVSVCGE | ASSDPDLGSK | IAKMLDDSAN | VIVLGDSVCI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RPDQVTKSIE | GLLPLPKIHN | PNDPRRIEFK | ELEAEKAVID | VKAHTLVRKE | LWAGLGYLIL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QTAGFMRLTF | WELSWDVMEP | ICFYVTSVYF | MAGYAFFLRT | SKEPSFEGFY | QSRFEAKQRK |
| 310 | 320 | 330 | |||
| LMNEYEFDLE | RYNELKKLFC | SKPSDHVSKI | LGAIKS |