Q08685
Gene name |
CLP1 |
Protein name |
mRNA cleavage and polyadenylation factor CLP1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOR250C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q08685
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2NPI | X-ray | 295 A | A/B | 2-445 | PDB |
| 4C0B | X-ray | 277 A | A/B | 1-445 | PDB |
| 4C0H | X-ray | 270 A | A/B | 1-445 | PDB |
| 4OI4 | X-ray | 240 A | A/C | 1-445 | PDB |
| AF-Q08685-F1 | Predicted | AlphaFoldDB |
4 variants for Q08685
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-801821 | 163 | Q>P | No | SGRP | |
| s15-801746 | 188 | T>I | No | SGRP | |
| s15-801594 | 239 | L>M | No | SGRP | |
| s15-801099 | 404 | P>S | No | SGRP |
No associated diseases with Q08685
4 regional properties for Q08685
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Neurotransmitter-gated ion-channel transmembrane domain | 242 - 355 | IPR006029-1 |
| domain | Neurotransmitter-gated ion-channel transmembrane domain | 370 - 431 | IPR006029-2 |
| domain | Neurotransmitter-gated ion-channel ligand-binding domain | 33 - 234 | IPR006202 |
| conserved_site | Neurotransmitter-gated ion-channel, conserved site | 155 - 169 | IPR018000 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mRNA cleavage factor complex | Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| polynucleotide 5'-hydroxyl-kinase activity | Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA 3'-end processing | Any process involved in forming the mature 3' end of an mRNA molecule. |
| mRNA polyadenylation | The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. |
| pre-mRNA cleavage required for polyadenylation | The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation. |
| RNA processing | Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. |
| tRNA splicing, via endonucleolytic cleavage and ligation | Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASLPGIDEH | TTSEELITGD | NEWHKLVIPK | GSDWQIDLKA | EGKLIVKVNS | GIVEIFGTEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AVDDEYTFQN | WKFPIYAVEE | TELLWKCPDL | TTNTITVKPN | HTMKYIYNLH | FMLEKIRMSN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FEGPRVVIVG | GSQTGKTSLS | RTLCSYALKF | NAYQPLYINL | DPQQPIFTVP | GCISATPISD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ILDAQLPTWG | QSLTSGATLL | HNKQPMVKNF | GLERINENKD | LYLECISQLG | QVVGQRLHLD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PQVRRSGCIV | DTPSISQLDE | NLAELHHIIE | KLNVNIMLVL | CSETDPLWEK | VKKTFGPELG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NNNIFFIPKL | DGVSAVDDVY | KRSLQRTSIR | EYFYGSLDTA | LSPYAIGVDY | EDLTIWKPSN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VFDNEVGRVE | LFPVTITPSN | LQHAIIAITF | AERRADQATV | IKSPILGFAL | ITEVNEKRRK |
| 430 | 440 | ||||
| LRVLLPVPGR | LPSKAMILTS | YRYLE |