Q07845
Gene name |
GRC3 (YLL035W) |
Protein name |
Polynucleotide 5'-hydroxyl-kinase GRC3 |
Names |
Protein GRC3 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YLL035W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q07845
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7Y18 | X-ray | 369 A | A/B/E | 1-632 | PDB |
| AF-Q07845-F1 | Predicted | AlphaFoldDB |
16 variants for Q07845
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s12-68625 | 16 | S>L | No | SGRP | |
| s12-68670 | 31 | E>G | No | SGRP | |
| s12-68740 | 54 | E>D | No | SGRP | |
| s12-69005 | 143 | F>I | No | SGRP | |
| s12-69011 | 145 | M>L | No | SGRP | |
| s12-69039 | 154 | R>K | No | SGRP | |
| s12-69077 | 167 | V>I | No | SGRP | |
| s12-69089 | 171 | N>D | No | SGRP | |
| s12-69381 | 268 | R>Q | No | SGRP | |
| s12-69395 | 273 | S>G | No | SGRP | |
| s12-70043 | 489 | D>N | No | SGRP | |
| s12-70055 | 493 | Q>E | No | SGRP | |
| s12-70064 | 496 | K>Q | No | SGRP | |
| s12-70134 | 519 | S>F | No | SGRP | |
| s12-70179 | 534 | K>R | No | SGRP | |
| s12-70305 | 576 | V>A | No | SGRP |
No associated diseases with Q07845
1 regional properties for Q07845
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain | 246 - 402 | IPR032319 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| Las1 complex | A four subunit complex, that comprises all the necessary RNA processing enzymes (endonuclease, polynucleotide kinase, and exonuclease) to mediate 'cistronic rRNA transcript ITS2 (internal transcribed spacer) cleavage' (GO:0000448). |
| nucleolar chromatin | The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| polynucleotide 5'-hydroxyl-kinase activity | Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| RNA processing | Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
| termination of RNA polymerase I transcription | A transcription termination process that completes the production of a ribosomal RNA transcript. RNAP I termination requires binding of a terminator protein to specific sequences downstream of the transcription unit. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q08685 | CLP1 | mRNA cleavage and polyadenylation factor CLP1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5SY16 | NOL9 | Polynucleotide 5'-hydroxyl-kinase NOL9 | Homo sapiens (Human) | PR |
| Q9U3B6 | nol-9 | Polynucleotide 5'-hydroxyl-kinase nol-9 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVIDSKQDLP | QYTKDSGSES | DSDSSNNFIV | ESPSIPSSKS | ATVVLNSEEY | EDDEGDDLNG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDAELIDNIT | YEGDEDETMF | VGLKEKQKLH | LSGVFRLQVV | KGGIVYNNVH | YNASREILTF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WHPLSQSIPT | IDFSHFAGWQ | DTFFMPRNNR | FKIRDEEFKS | FPCVLRVFNS | NHTGLLEAGH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LYRDVNYLWK | PKEPYFPLNE | RTTYHLLHES | DRIQSLSVPG | YWSTPLEKLY | LSHKNAAYDT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RIMVIGGKNS | GKSTFLRLLL | EKFTQDIRDS | TTSQEELVYL | DLDPGQPEYS | LPDSISLNKI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSSPISLGQH | LCQGSNFQTL | LQFYAGSSSP | QDEPTSYLNC | ADKLIDHLEE | QAFFGTSLLN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LPGWIKGFGM | QILNHIIRKY | KPTHLLFLET | ANSKRHLDEL | TIPQSFSTSL | RDAYAPEVVR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VPAHSLNHTL | SSRFHASQLR | TFKILALFHK | ITQFDYDFAP | LLKSAPLQIS | YGKGKSGIKG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IQFPMEFQDL | NPQDIKSALE | GTVIGIYTYS | GEDSLEVKSL | NTFPILQSCT | SSSKNFITLG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LIHSIDTSQQ | IMNIYVPPCH | TQILDKQPED | AQWIIVRNKT | ETPFCDFLPS | PRTITWDDNI |
| 610 | 620 | 630 | |||
| QIPFATFERR | KKLEHVWKVR | KNVMRRGQFM | KR |