Q08213
Gene name |
NGL1 (YOL042W) |
Protein name |
RNA exonuclease NGL1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YOL042W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q08213
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q08213-F1 | Predicted | AlphaFoldDB |
4 variants for Q08213
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s15-249953 | 44 | V>I | No | SGRP | |
| s15-250091 | 90 | H>Y | No | SGRP | |
| s15-250174 | 117 | K>N | No | SGRP | |
| s15-250538 | 239 | V>I | No | SGRP |
No associated diseases with Q08213
1 regional properties for Q08213
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Endonuclease/exonuclease/phosphatase | 30 - 353 | IPR005135 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| CCR4-NOT complex | The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5'-exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| poly(A)-specific ribonuclease activity | Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| nuclear-transcribed mRNA poly(A) tail shortening | Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. |
2 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P31384 | CCR4 | CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q03210 | NGL3 | Probable RNA exonuclease NGL3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFTRRFIPVV | QSTKQNIGKY | VRKDARFTLL | TYNMLSPSYM | WPQVYTYVAE | PYKNWSYRHR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLEKELLNTF | KADIMCLQEM | TARDYEDYWH | DSIGVDVNYG | SKFISKTPPK | YWKKPVKDMD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GVSIFYNLAK | FDFISSSGIY | LNQLLNVFNQ | RELKYLYNKK | VTLTDGASNV | IGEDSLLDVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KGKNQVCLFV | SLRHKETGTI | FVVLNTHLYW | KYDEVKLTQC | MIIMRELSKI | IKQLLPGDVK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GQERVKILFT | GDLNSTRDSL | VVNFLQGQIV | SHGDLNLINP | MRPYLDRCVY | DDIPKDYFVH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TCYSGKLKGI | FDYVWYHDSD | FLLTKILTGN | EVSDELLASN | QLGLPNENHP | SDHIPLLTEF |
| KIL |