Q03210

PR
Gene name
NGL3 (YML118W, YM7056.08, YM8339.01)
Protein name
Probable RNA exonuclease NGL3
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YML118W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q03210

Entry ID Method Resolution Chain Position Source
AF-Q03210-F1 Predicted AlphaFoldDB

16 variants for Q03210

Variant ID(s) Position Change Description Diseaes Association Provenance
s13-32342 3 S>R No SGRP
s13-32346 5 V>I No SGRP
s13-32457 42 V>L No SGRP
s13-32646 105 D>N No SGRP
s13-32855 174 K>N No SGRP
s13-32868 179 V>M No SGRP
s13-32986 218 V>A No SGRP
s13-33019 229 A>V No SGRP
s13-33027 232 I>V No SGRP
s13-33068 245 R>S No SGRP
s13-33273 314 L>I No SGRP
s13-33705 458 I>L No SGRP
s13-33754 474 S>C No SGRP
s13-33822 497 G>W No SGRP
s13-33829 499 E>G No SGRP
s13-33845 504 L>F No SGRP

No associated diseases with Q03210

No regional properties for Q03210

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q03210

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
poly(A)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.

1 GO annotations of biological process

Name Definition
polyadenylation-dependent RNA catabolic process The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P31384 CCR4 CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q08213 NGL1 RNA exonuclease NGL1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MDSQVEGKIS PSQKESSSTS GLVSPSEDGP AHQKIHRDQL SVDQIKKIRE ERAQKRQVRR
70 80 90 100 110 120
NSLISQGKDP DFPTPDLQFI ERPFLPINHD NSKGLTPATI QVTQDSLDVK IMTYNTLAQT
130 140 150 160 170 180
LIRRDFFPES GPALKWHKRS KVLVHELKKY RPDVVSLQEV DYNELNFWQE NFHKLGFDVI
190 200 210 220 230 240
FKRHEGKTHG LLVAWNNKKF QLDNDWMLDY DNILAGNVIS ARTRTKNIAL IISLYFKGIT
250 260 270 280 290 300
DSSSRGIIVA NTHLFWHPFG VFERLRQSYL VLQKIQEIKA CSKYNGWHSL LMGDFNTEPE
310 320 330 340 350 360
EPPYLAITKR PLILKGPIRA MVECSLAYRY SKKRNGEESD QDDEECDEKS RGEGHSDQPQ
370 380 390 400 410 420
NPKPESFTAT KEEKALVNQL VALHNSLHVK GVSLYGIGYG KVHPENANGS HGEPGLSNWA
430 440 450 460 470 480
NTWCGLLDYI FYIEGDHNQD TRQKEPLNAF EGNNNVKIIG YLRMPCAQEM PKHSQPFEGE
490 500
YASDHISLMC QIRLFFGGEK VHSLK