Q08204

PR
Gene name
SMC5 (YOL034W)
Protein name
Structural maintenance of chromosomes protein 5
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YOL034W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q08204

Entry ID Method Resolution Chain Position Source
3HTK X-ray 231 A PDB
7P47 X-ray 331 A B 737-777 PDB
7QCD EM 800 A A 1-1093 PDB
7TVE EM 380 A E 1-1093 PDB
7YQH EM 560 A A 1-1093 PDB
8T8F EM 480 A D 1-1093 PDB
AF-Q08204-F1 Predicted AlphaFoldDB

21 variants for Q08204

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-260341 140 I>V No SGRP
s15-260427 168 Q>H No SGRP
s15-260585 221 N>S No SGRP
s15-260608 229 L>F No SGRP
s15-260614 231 F>V No SGRP
s15-260678 252 S>C No SGRP
s15-261119 399 E>G No SGRP
s15-261314 464 E>A No SGRP
s15-261554 544 T>I No SGRP
s15-261557 545 T>N No SGRP
s15-261563 547 P>L No SGRP
s15-261584 554 R>K No SGRP
s15-261589 556 L>V No SGRP
s15-261841 640 I>F No SGRP
s15-261916 665 N>D No SGRP
s15-261928 669 E>Q No SGRP
s15-261980 686 G>V No SGRP
s15-262028 702 N>S No SGRP
s15-262168 749 D>N No SGRP
s15-262453 844 T>A No SGRP
s15-263194 1091 S>T No SGRP

No associated diseases with Q08204

1 regional properties for Q08204

Type Name Position InterPro Accession
domain RecF/RecN/SMC, N-terminal 42 - 1048 IPR003395

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Smc5-Smc6 complex A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
damaged DNA binding Binding to damaged DNA.
single-stranded DNA binding Binding to single-stranded DNA.

7 GO annotations of biological process

Name Definition
chromosome separation The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II).
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
protein sumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
recombinational repair A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.
regulation of telomere maintenance Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
resolution of recombination intermediates The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IY18 SMC5 Structural maintenance of chromosomes protein 5 Homo sapiens (Human) PR
Q8CG46 Smc5 Structural maintenance of chromosomes protein 5 Mus musculus (Mouse) PR
10 20 30 40 50 60
MTSLIDLGRY VERTHHGEDT EPRSKRVKIA KPDLSSFQPG SIIKIRLQDF VTYTLTEFNL
70 80 90 100 110 120
SPSLNMIIGP NGSGKSTFVC AVCLGLAGKP EYIGRSKKVE DFIKNGQDVS KIEITLKNSP
130 140 150 160 170 180
NVTDIEYIDA RDETIKITRI ITRSKRRSDY LINDYQVSES VVKTLVAQLN IQLDNLCQFL
190 200 210 220 230 240
SQERVEEFAR LKSVKLLVET IRSIDASLLD VLDELRELQG NEQSLQKDLD FKKAKIVHLR
250 260 270 280 290 300
QESDKLRKSV ESLRDFQNKK GEIELHSQLL PYVKVKDHKE KLNIYKEEYE RAKANLRAIL
310 320 330 340 350 360
KDKKPFANTK KTLENQVEEL TEKCSLKTDE FLKAKEKINE IFEKLNTIRD EVIKKKNQNE
370 380 390 400 410 420
YYRGRTKKLQ ATIISTKEDF LRSQEILAQT HLPEKSVFED IDIKRKEIIN KEGEIRDLIS
430 440 450 460 470 480
EIDAKANAIN HEMRSIQRQA ESKTKSLTTT DKIGILNQDQ DLKEVRDAVL MVREHPEMKD
490 500 510 520 530 540
KILEPPIMTV SAINAQFAAY LAQCVDYNTS KALTVVDSDS YKLFANPILD KFKVNLRELS
550 560 570 580 590 600
SADTTPPVPA ETVRDLGFEG YLSDFITGDK RVMKMLCQTS KIHTIPVSRR ELTPAQIKKL
610 620 630 640 650 660
ITPRPNGKIL FKRIIHGNRL VDIKQSAYGS KQVFPTDVSI KQTNFYQGSI MSNEQKIRIE
670 680 690 700 710 720
NEIINLKNEY NDRKSTLDAL SNQKSGYRHE LSELASKNDD INREAHQLNE IRKKYTMRKS
730 740 750 760 770 780
TIETLREKLD QLKREARKDV SQKIKDIDDQ IQQLLLKQRH LLSKMASSMK SLKNCQKELI
790 800 810 820 830 840
STQILQFEAQ NMDVSMNDVI GFFNEREADL KSQYEDKKKF VKEMRDTPEF QSWMREIRSY
850 860 870 880 890 900
DQDTKEKLNK VAEKYEEEGN FNLSFVQDVL DKLESEIAMV NHDESAVTIL DQVTAELREL
910 920 930 940 950 960
EHTVPQQSKD LETIKAKLKE DHAVLEPKLD DIVSKISARF ARLFNNVGSA GAVRLEKPKD
970 980 990 1000 1010 1020
YAEWKIEIMV KFRDNAPLKK LDSHTQSGGE RAVSTVLYMI ALQEFTSAPF RVVDEINQGM
1030 1040 1050 1060 1070 1080
DSRNERIVHK AMVENACAEN TSQYFLITPK LLTGLHYHEK MRIHCVMAGS WIPNPSEDPK
1090
MIHFGETSNY SFD