Q03195

PR
Gene name
RLI1 (YDR091C)
Protein name
Translation initiation factor RLI1
Names
ATP-binding cassette sub-family E member RLI1, RNase L inhibitor
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR091C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

553-608 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for Q03195

Entry ID Method Resolution Chain Position Source
3J16 EM - B 1-608 PDB
4CRM EM 875 A P 1-608 PDB
5LL6 EM 390 A h 1-608 PDB
6ZCE EM 530 A k 1-608 PDB
6ZU9 EM 620 A k 1-608 PDB
7A1G EM 300 A x 4-604 PDB
8CAH EM 300 A x 1-608 PDB
8CAS EM 330 A k 1-608 PDB
AF-Q03195-F1 Predicted AlphaFoldDB

No variants for Q03195

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q03195

No associated diseases with Q03195

9 regional properties for Q03195

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 70 - 320 IPR003439-1
domain ABC transporter-like, ATP-binding domain 345 - 568 IPR003439-2
domain AAA+ ATPase domain 102 - 298 IPR003593-1
domain AAA+ ATPase domain 377 - 545 IPR003593-2
domain RNase L inhibitor RLI-like, possible metal-binding domain 7 - 37 IPR007209
conserved_site ABC transporter-like, conserved site 468 - 482 IPR017871
domain 4Fe-4S ferredoxin-type, iron-sulphur binding domain 46 - 75 IPR017896
conserved_site 4Fe-4S ferredoxin, iron-sulphur binding, conserved site 55 - 66 IPR017900
domain RLI, domain 1 78 - 337 IPR034348

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Shuttles between the nucleus and the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
iron ion binding Binding to an iron (Fe) ion.
ribosomal small subunit binding Binding to a small ribosomal subunit.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

7 GO annotations of biological process

Name Definition
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
ribosomal subunit export from nucleus The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.
ribosome disassembly The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9LID6 ABCE1 ABC transporter E family member 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LPJ4 ABCE2 ABC transporter E family member 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSDKNSRIAI VSADKCKPKK CRQECKRSCP VVKTGKLCIE VTPTSKIAFI SEILCIGCGI
70 80 90 100 110 120
CVKKCPFDAI QIINLPTNLE AHVTHRYSAN SFKLHRLPTP RPGQVLGLVG TNGIGKSTAL
130 140 150 160 170 180
KILAGKQKPN LGRFDDPPEW QEIIKYFRGS ELQNYFTKML EDDIKAIIKP QYVDNIPRAI
190 200 210 220 230 240
KGPVQKVGEL LKLRMEKSPE DVKRYIKILQ LENVLKRDIE KLSGGELQRF AIGMSCVQEA
250 260 270 280 290 300
DVYMFDEPSS YLDVKQRLNA AQIIRSLLAP TKYVICVEHD LSVLDYLSDF VCIIYGVPSV
310 320 330 340 350 360
YGVVTLPASV REGINIFLDG HIPAENLRFR TEALQFRIAD ATEDLQNDSA SRAFSYPSLK
370 380 390 400 410 420
KTQGDFVLNV EEGEFSDSEI LVMMGENGTG KTTLIKLLAG ALKPDEGQDI PKLNVSMKPQ
430 440 450 460 470 480
KIAPKFPGTV RQLFFKKIRG QFLNPQFQTD VVKPLRIDDI IDQEVQHLSG GELQRVAIVL
490 500 510 520 530 540
ALGIPADIYL IDEPSAYLDS EQRIICSKVI RRFILHNKKT AFIVEHDFIM ATYLADKVIV
550 560 570 580 590 600
FEGIPSKNAH ARAPESLLTG CNRFLKNLNV TFRRDPNSFR PRINKLDSQM DKEQKSSGNY
FFLDNTGI