Q03043
SS
Gene name |
for (DG2, PGK2, Pkg24A, CG10033) |
Protein name |
cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B |
Names |
cGK , EC 2.7.11.12 , Foraging protein |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
|
EC number |
2.7.11.12: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
PKG is a major intracellular receptor of cGMP and modulates diverse cellular signalings. The activity of PKG1B is regulated by its N-terminal regulatory (R) domain, which includes a leucine zipper (LZ) domain, a linker region with an autoinhibitory (AI) sequence, and two cyclic nucleotide-binding (CNB-A and -B) domains. In the autoinhibition of PKG1B, the AI sequence from R domain binds to the catalytic cleft of the C domain, blocking substrate access and inhibiting the enzymatic activity. This autoinhibition is alleviated by the binding of cyclic guanosine monophosphate (cGMP) to the CNB domains, which destabilizes the autoinhibited state and allows the active kinase to phosphorylate downstream substrate.
Autoinhibitory domains (AIDs)
Target domain |
772-1088 (C-terminal catalytic domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for Q03043
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| No available structures | |||||
No variants for Q03043
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q03043 | |||||
No associated diseases with Q03043
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.12 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cGMP binding | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| cGMP-dependent protein kinase activity | cGMP dependent catalysis of the reaction |
| protein serine kinase activity | Catalysis of the reactions |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| feeding behavior | Behavior associated with the intake of food. |
| habituation | A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented. |
| larval feeding behavior | Feeding behavior in a larval (immature) organism. |
| larval locomotory behavior | Locomotory behavior in a larval (immature) organism. |
| long-term memory | The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. |
| motor neuron axon guidance | The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. |
| positive regulation of Toll signaling pathway | Any process that activates or increases the frequency, rate or extent of the Tl signaling pathway. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| receptor guanylyl cyclase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| regulation of heart contraction | Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. |
| regulation of response to food | Any process that modulates the frequency, rate or extent of a response to a food stimulus. |
| response to sucrose | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus. |
| short-term memory | The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation. |
16 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P00517 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Bos taurus (Bovine) | PR |
| P00516 | PRKG1 | cGMP-dependent protein kinase 1 | Bos taurus (Bovine) | SS |
| P16911 | Pka-C2 | cAMP-dependent protein kinase catalytic subunit 2 | Drosophila melanogaster (Fruit fly) | PR |
| P17612 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (Human) | PR |
| Q13237 | PRKG2 | cGMP-dependent protein kinase 2 | Homo sapiens (Human) | PR |
| Q13976 | PRKG1 | cGMP-dependent protein kinase 1 | Homo sapiens (Human) | EV |
| P05132 | Prkaca | cAMP-dependent protein kinase catalytic subunit alpha | Mus musculus (Mouse) | PR |
| Q922R0 | Prkx | cAMP-dependent protein kinase catalytic subunit PRKX | Mus musculus (Mouse) | PR |
| P0C605 | Prkg1 | cGMP-dependent protein kinase 1 | Mus musculus (Mouse) | SS |
| Q61410 | Prkg2 | cGMP-dependent protein kinase 2 | Mus musculus (Mouse) | PR |
| P36887 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Sus scrofa (Pig) | PR |
| Q64595 | Prkg2 | cGMP-dependent protein kinase 2 | Rattus norvegicus (Rat) | PR |
| O62846 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | Macaca mulatta (Rhesus macaque) | PR |
| Q7JP68 | F47F2.1 | cAMP-dependent protein kinase, catalytic subunit-like | Caenorhabditis elegans | PR |
| P21137 | kin-1 | cAMP-dependent protein kinase catalytic subunit | Caenorhabditis elegans | PR |
| O76360 | egl-4 | cGMP-dependent protein kinase egl-4 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRFCFDRLCF | ATKRPAQNSN | SNAPHSSTTV | DAPPRPADVD | VATVPVATPA | PPPQQPVSNL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FYADYQKLQP | AIIDRDWERD | RDTDTDTRSE | AKPPDIVEHI | EPVEEQRQIH | TQIQSPAEIQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IQIPPTPPAP | SIQIQIQQRY | RRHSSAEDRN | LNTRRNDSNI | TEALRKAASM | QQEPNANYQF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PTDLGLVSIV | NNNNNTNTHP | SGSNSGSNNN | SNINNNLVGG | IVTLPAAGGL | IGLEHTASGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLIPAPPTHS | DVLTHTLIYG | TPPSGAQQLN | QDPRSLLHQQ | ELQLQQRYQQ | LQQLQAQTQG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LYTSQGSPVL | YHQPSPGSSQ | PVAIPGATCH | SPTQLQPPNT | LNLQQQMQSL | RISGCTPSGT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GGSATPSPVG | LVDPNFIVSN | YVAASPQEER | FIQIIQAKEL | KIQEMQRALQ | FKDNEIAELK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SHLDKFQSVF | PFSRGSAAGC | AGTGGASGSG | AGGSGGSGPG | TATGATRKSG | QNFQRQRALG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ISAEPQSESS | LLLEHVSFPK | YDKDERSREL | IKAAILDNDF | MKNLDLTQIR | EIVDCMYPVK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YPAKNLIIKE | GDVGSIVYVM | EDGRVEVSRE | GKYLSTLSGA | KVLGELAILY | NCQRTATITA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ITECNLWAIE | RQCFQTIMMR | TGLIRQAEYS | DFLKSVPIFK | DLAEDTLIKI | SDVLEETHYQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RGDYIVRQGA | RGDTFFIISK | GKVRVTIKQQ | DTQEEKFIRM | LGKGDFFGEK | ALQGDDLRTA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NIICESADGV | SCLVIDRETF | NQLISNLDEI | KHRYDDEGAM | ERRKINEEFR | DINLTDLRVI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ATLGVGGFGR | VELVQTNGDS | SRSFALKQMK | KSQIVETRQQ | QHIMSEKEIM | GEANCQFIVK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LFKTFKDKKY | LYMLMESCLG | GELWTILRDK | GNFDDSTTRF | YTACVVEAFD | YLHSRNIIYR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DLKPENLLLN | ERGYVKLVDF | GFAKKLQTGR | KTWTFCGTPE | YVAPEVILNR | GHDISADYWS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LGVLMFELLT | GTPPFTGSDP | MRTYNIILKG | IDAIEFPRNI | TRNASNLIKK | LCRDNPAERL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| GYQRGGISEI | QKHKWFDGFY | WWGLQNCTLE | PPIKPAVKSV | VDTTNFDDYP | PDPEGPPPDD |
| VTGWDKDF |