O62846
Gene name |
PRKACG |
Protein name |
cAMP-dependent protein kinase catalytic subunit gamma |
Names |
PKA C-gamma |
Species |
Macaca mulatta (Rhesus macaque) |
KEGG Pathway |
|
EC number |
2.7.11.11: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O62846
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O62846-F1 | Predicted | AlphaFoldDB |
No variants for O62846
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O62846 | |||||
1 associated diseases with O62846
Without disease ID
No regional properties for O62846
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O62846 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.11 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| AMP-activated protein kinase activity | Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cAMP-dependent protein kinase activity | cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P00517 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Bos taurus (Bovine) | PR |
| P16911 | Pka-C2 | cAMP-dependent protein kinase catalytic subunit 2 | Drosophila melanogaster (Fruit fly) | PR |
| Q03043 | for | cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B | Drosophila melanogaster (Fruit fly) | SS |
| P17612 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (Human) | PR |
| P05132 | Prkaca | cAMP-dependent protein kinase catalytic subunit alpha | Mus musculus (Mouse) | PR |
| Q922R0 | Prkx | cAMP-dependent protein kinase catalytic subunit PRKX | Mus musculus (Mouse) | PR |
| P36887 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | Sus scrofa (Pig) | PR |
| Q7JP68 | F47F2.1 | cAMP-dependent protein kinase, catalytic subunit-like | Caenorhabditis elegans | PR |
| P21137 | kin-1 | cAMP-dependent protein kinase catalytic subunit | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNAAAKKDT | EQETVNEFLA | KARGDFLYRW | GNPAQNTASS | DQFERLKTLG | TGSYGRVMLV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RHRETGNHYA | MKILDKQKVV | RLKQVEHTLN | EKRILQAINF | PFLVKLQFSF | KDNSNLYLVM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EYVPGGEMFS | HLRRVGRFSE | PQACFYAAQV | VLAFQYLHSL | DLIHRDLKPE | NLLIDQQGYL |
| 190 | 200 | ||||
| QVTDFGFAKR | VKGRTWTLCG | TPEYLAPEI |