Q61410
Gene name |
Prkg2 (Prkgr2) |
Protein name |
cGMP-dependent protein kinase 2 |
Names |
cGK 2, cGK2, cGMP-dependent protein kinase II, cGKII |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
|
EC number |
2.7.11.12: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
593-615 (Activation loop from InterPro)
Target domain |
453-711 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for Q61410
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q61410-F1 | Predicted | AlphaFoldDB |
No variants for Q61410
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q61410 | |||||
No associated diseases with Q61410
10 regional properties for Q61410
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Death domain | 850 - 941 | IPR000488 |
| repeat | Thrombospondin type-1 (TSP1) repeat | 250 - 304 | IPR000884-1 |
| repeat | Thrombospondin type-1 (TSP1) repeat | 306 - 358 | IPR000884-2 |
| domain | ZU5 domain | 543 - 685 | IPR000906 |
| domain | Immunoglobulin subtype 2 | 169 - 236 | IPR003598 |
| domain | Immunoglobulin subtype | 163 - 248 | IPR003599 |
| domain | Immunoglobulin-like domain | 164 - 242 | IPR007110 |
| domain | Immunoglobulin I-set | 158 - 246 | IPR013098 |
| domain | UPA domain | 690 - 829 | IPR033772 |
| domain | UNC5D, Death domain | 856 - 953 | IPR042058 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.12 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| cGMP binding | Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). |
| cGMP-dependent protein kinase activity | cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. |
| identical protein binding | Binding to an identical protein or proteins. |
| mitogen-activated protein kinase binding | Binding to a mitogen-activated protein kinase. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular hypotonic response | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. |
| circadian regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. |
| circadian rhythm | Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
| negative regulation of cell volume | Any process that decreases cell volume. |
| negative regulation of chloride transport | Any process that stops, prevents or reduces the frequency, rate or extent of chloride transport. |
| negative regulation of chondrocyte proliferation | Any process that stops, prevents, or reduces the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. |
| peptidyl-serine autophosphorylation | The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of chondrocyte differentiation | Any process that modulates the frequency, rate or extent of chondrocyte differentiation. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P00516 | PRKG1 | cGMP-dependent protein kinase 1 | Bos taurus (Bovine) | SS |
| Q03043 | for | cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B | Drosophila melanogaster (Fruit fly) | SS |
| Q13976 | PRKG1 | cGMP-dependent protein kinase 1 | Homo sapiens (Human) | EV |
| Q13237 | PRKG2 | cGMP-dependent protein kinase 2 | Homo sapiens (Human) | PR |
| P0C605 | Prkg1 | cGMP-dependent protein kinase 1 | Mus musculus (Mouse) | SS |
| P05132 | Prkaca | cAMP-dependent protein kinase catalytic subunit alpha | Mus musculus (Mouse) | PR |
| Q922R0 | Prkx | cAMP-dependent protein kinase catalytic subunit PRKX | Mus musculus (Mouse) | PR |
| Q64595 | Prkg2 | cGMP-dependent protein kinase 2 | Rattus norvegicus (Rat) | PR |
| O76360 | egl-4 | cGMP-dependent protein kinase egl-4 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNGSVKPKH | AKHPDGHSGN | LSNEALRSKV | LELERELRRK | DAELQEREYH | LKELREQLAK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QTVAIAELTE | ELQSKCIQLN | KLQDVIHVQG | GSPLQASPDK | VPLDVHRKTS | GLVSLHSRRG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AKAGVSAEPT | TRTYDLNKPP | EFSFEKARVR | KDSSEKKLIT | DALNKNQFLK | RLDPQQIKDM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VECMYGEKLS | TGSYVIKQGE | PGNHIFVLAE | GRLEVFQGEK | LLSSIPMWTT | FGELAILYNC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TRTASVKAIT | NVKTWALDRE | VFQNIMRRTA | QARDEEYRNF | LRSVSLLKNL | PEDKLTKIID |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CLEVEYYDKG | DYIIREGEEG | STFFILAKGK | VKVTQSTEGH | DQPQLIKTLQ | KGEYFGEKAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ISDDVRSANI | IAEENDVACL | VIDRETFNQT | VGTFDELQKY | LEGYVATLNR | DDEKRHAKRS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MSSWKLSKAL | SLEMIQLKEK | VARFSSTSPF | QNLEIIATLG | VGGFGRVELV | KVKNENVAFA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MKCIRKKHIV | DTKQQEHVYS | EKRILEELCS | PFIVKLYRTF | KDNKYVYMLL | EACLGGELWS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ILRDRGSFDE | PTSKFCVACV | TEAFDYLHLL | GIIYRDLKPE | NLILDADGYL | KLVDFGFAKK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IGSGQKTWTF | CGTPEYVAPE | VILNKGHDFS | VDFWSLGILV | YELLTGNPPF | SGIDQMMTYN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LILKGIEKMD | FPRKITRRPE | DLIRRLCRQN | PTERLGNLKN | GINDIKKHRW | LNGFNWEGLK |
| 730 | 740 | 750 | 760 | ||
| ARSLPSPLRR | ELSGPIDHSY | FDKYPPEKGV | PPDEMSGWDK | DF |