Q02883
Gene name |
FMP30 (YPL103C) |
Protein name |
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrial |
Names |
NAPE-PLD, NAPE-hydrolyzing phospholipase D, Found in mitochondrial proteome protein 30 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPL103C |
EC number |
3.1.4.54: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q02883
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q02883-F1 | Predicted | AlphaFoldDB |
8 variants for Q02883
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-359255 | 50 | C>S | No | SGRP | |
| s16-359172 | 78 | V>M | No | SGRP | |
| s16-359112 | 98 | V>L | No | SGRP | |
| s16-358958 | 149 | R>P | No | SGRP | |
| s16-358905 | 167 | P>S | No | SGRP | |
| s16-358626 | 260 | I>V | No | SGRP | |
| s16-358555 | 283 | D>E | No | SGRP | |
| s16-358184 | 407 | Q>P | No | SGRP |
No associated diseases with Q02883
1 regional properties for Q02883
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Metallo-beta-lactamase | 224 - 426 | IPR001279 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.54 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of mitochondrial inner membrane | The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity | Catalysis of the reaction: H2O + an N-acylphosphatidylethanolamine = H+ + an N-acylethanolamine + a 1,2-diacyl-sn-glycerol 3-phosphate. |
| N-acylphosphatidylethanolamine-specific phospholipase D activity | Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| N-acylethanolamine metabolic process | The chemical reactions and pathways involving N-acylethanolamines. An N-acylethanolamine is an ethanolamine substituted at nitrogen by an acyl group. |
| N-acylphosphatidylethanolamine metabolic process | The chemical reactions and pathways involving N-acylphosphatidylethanolamines. An N-acylphosphatidylethanolamine is a phosphatidylethanolamine substituted at nitrogen by an acyl group. |
| phospholipid catabolic process | The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q58CN9 | NAPEPLD | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | Bos taurus (Bovine) | PR |
| Q6IQ20 | NAPEPLD | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | Homo sapiens (Human) | PR |
| Q8BH82 | Napepld | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | Mus musculus (Mouse) | PR |
| Q769K2 | Napepld | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNFVTCHVQM | RLLLQRRLVR | LRESELFRPQ | TSLSTFKRHA | SQKTRPIQKC | SRKYARILLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SVLVPYTGYA | FYVSLATVKQ | IDLRNEMCQR | LEENNNEVTY | KGSLLKYSPL | EVLGRFENPF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEYRIQTVFE | FFANRVFELF | ERNRGGIPRD | VHQMNKLMPV | HKPTWGPNLV | DVDPAEETAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLECKVLDEL | HIPTAVEENE | GSKCPVYNTW | LGQSCNYTVY | NGLRILTDPL | FSDFLIHKTL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GPKRITQMPS | QITEVPKPDI | ILVSHNHPDH | LDLESLEYWS | GKDSPLWIVP | KGMKSYMTSN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GCDNVLELSW | WETLQVKKNN | EIYHISATPA | MHWSGRSLLD | TNKSLWCSFL | LTHHGNPILF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HAGDTGYVKD | LFVRIKERFG | KGCKLALLPC | GQYCPEWHQK | PRHINPQEVL | KIMKDLEARN |
| 430 | 440 | 450 | 460 | ||
| VLGVHWGTFV | LSGEYFLEPK | EKLEMLAEWG | GFKDRCYCPE | LGKTECFD |