AiPD: Autoinhibited Protein Database

Gene name	Bckdk
Protein name	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
Names	Branched-chain alpha-ketoacid dehydrogenase kinase, BCKD-kinase, BCKDHKIN
Species	Rattus norvegicus (Rat)
KEGG Pathway	rno:29603
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-67 (Predicted disordered autoinhibitory region) PR

1-67 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1GJV	X-ray	270 A	A	31-412	PDB
1GKX	X-ray	230 A	A	31-412	PDB
1GKZ	X-ray	220 A	A	31-412	PDB
3TZ0	X-ray	250 A	A	1-412	PDB
3TZ2	X-ray	285 A	A	1-412	PDB
3TZ4	X-ray	225 A	A	1-412	PDB
3TZ5	X-ray	240 A	A	1-412	PDB
3VAD	X-ray	260 A	A	1-412	PDB
4DZY	X-ray	210 A	A	1-412	PDB
4E00	X-ray	215 A	A	1-412	PDB
4E01	X-ray	197 A	A	1-412	PDB
4E02	X-ray	215 A	A	1-412	PDB
4H7Q	X-ray	210 A	A	1-412	PDB
4H81	X-ray	205 A	A	1-412	PDB
4H85	X-ray	210 A	A	1-412	PDB
8EGD	X-ray	205 A	A	31-412	PDB
8EGF	X-ray	185 A	A	31-412	PDB
8EGQ	X-ray	196 A	A	31-412	PDB
8EGU	X-ray	192 A	A	31-412	PDB
8F4Q	X-ray	215 A	A	31-412	PDB
AF-Q00972-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs197560774	80	R>H	No	EVA
rs198804998	99	P>S	No	EVA
rs198586775	108	G>A	No	EVA
rs197934398	195	T>K	No	EVA
rs198044318	261	R>G	No	EVA
rs197801776	286	E>G	No	EVA
rs197547988	331	Y>H	No	EVA
rs197006299	336	A>S	No	EVA
rs198618360	344	R>Q	No	EVA
rs198459511	346	S>G	No	EVA
rs198297098	401	R>C	No	EVA

Type	Name	Position	InterPro Accession
domain	Histidine kinase/HSP90-like ATPase	264 - 404	IPR003594
domain	Signal transduction histidine kinase-related protein, C-terminal	309 - 323	IPR004358-1
domain	Signal transduction histidine kinase-related protein, C-terminal	364 - 382	IPR004358-2
domain	Signal transduction histidine kinase-related protein, C-terminal	388 - 401	IPR004358-3
domain	Histidine kinase domain	269 - 404	IPR005467
domain	Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal	73 - 222	IPR018955

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Mitochondrion matrix Mitochondrion	Detected in the cytosolic compartment of liver cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrial alpha-ketoglutarate dehydrogenase complex	Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
pyruvate dehydrogenase (acetyl-transferring) kinase activity	Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.

Name	Definition
branched-chain amino acid catabolic process	The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
isoleucine catabolic process	The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R,3R)-2-amino-3-methylpentanoic acid.
leucine catabolic process	The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of glucose metabolic process	Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
valine catabolic process	The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P53170	PKP2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P40530	PKP1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q15118	PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	Homo sapiens (Human)	PR
Q15120	PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	Homo sapiens (Human)	PR
O55028	Bckdk	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Mus musculus (Mouse)	PR