AiPD: Autoinhibited Protein Database

Gene name	Bckdk
Protein name	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
Names	Branched-chain alpha-ketoacid dehydrogenase kinase, BCKD-kinase, BCKDHKIN
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:12041
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-71 (Predicted disordered autoinhibitory region) PR

1-71 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O55028-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs259681526	5	S>T	No	EVA
rs3388953463	9	S>N	No	EVA
rs217194612	14	W>R	No	EVA
rs3388940468	30	R>P	No	EVA
rs3388953456	91	G>D	No	EVA
rs3388940467	96	Q>R	No	EVA
rs3388953485	102	I>N	No	EVA
rs3388956836	127	E>K	No	EVA
rs3388953443	133	F>I	No	EVA
rs3388908165	133	F>L	No	EVA
rs3388946470	134	Q>R	No	EVA
rs3388930072	152	C>Y	No	EVA
rs3388953622	171	E>D	No	EVA
rs3388940427	208	L>M	No	EVA
rs3388953415	221	I>F	No	EVA
rs3388908191	222	C>Y	No	EVA
rs3388955949	228	K>M	No	EVA
rs3388945648	262	F>I	No	EVA
rs3398534063	273	L>Q	No	EVA
rs3388950562	274	P>H	No	EVA
rs3388956886	285	M>L	No	EVA
rs3388908223	290	D>N	No	EVA
rs3388953468	308	D>V	No	EVA
rs3398534055	313	I>M	No	EVA
rs3398390587	362	P>ILGRWGLTHA*	No	EVA
rs3388945631	395	D>E	No	EVA

Type	Name	Position	InterPro Accession
domain	Bicarbonate transporter-like, transmembrane domain	680 - 1168	IPR011531
domain	Band 3 cytoplasmic domain	352 - 619	IPR013769
conserved_site	Anion exchange, conserved site	682 - 693	IPR018241-1
conserved_site	Anion exchange, conserved site	829 - 843	IPR018241-2

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Mitochondrion matrix Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mitochondrial alpha-ketoglutarate dehydrogenase complex	Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity	Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
pyruvate dehydrogenase (acetyl-transferring) kinase activity	Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate.

Name	Definition
branched-chain amino acid catabolic process	The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
isoleucine catabolic process	The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R,3R)-2-amino-3-methylpentanoic acid.
leucine catabolic process	The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid.
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
regulation of glucose metabolic process	Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
valine catabolic process	The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P53170	PKP2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase 2, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P40530	PKP1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q15118	PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	Homo sapiens (Human)	PR
Q15120	PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	Homo sapiens (Human)	PR
Q00972	Bckdk	[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial	Rattus norvegicus (Rat)	PR