P97478

PR
Gene name
Coq7
Protein name
5-demethoxyubiquinone hydroxylase, mitochondrial
Names
DMQ hydroxylase, Timing protein clk-1 homolog, Ubiquinone biosynthesis monooxygenase COQ7
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:12850
EC number
1.14.99.60: Miscellaneous
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P97478

Entry ID Method Resolution Chain Position Source
AF-P97478-F1 Predicted AlphaFoldDB

15 variants for P97478

Variant ID(s) Position Change Description Diseaes Association Provenance
rs259750667 14 R>C No EVA
rs3388945815 68 A>V No EVA
rs3388944632 75 G>D No EVA
rs3388946673 95 K>N No EVA
rs3388939693 96 K>R No EVA
rs3388946694 121 A>V No EVA
rs3388913632 136 A>G No EVA
rs3388929854 157 M>T No EVA
rs3388899069 158 E>K No EVA
rs3388934912 161 P>T No EVA
rs3388939864 165 E>K No EVA
rs3388920144 174 F>S No EVA
rs3388934916 182 H>L No EVA
rs3388939821 186 L>M No EVA
rs222667909 189 D>G No EVA

No associated diseases with P97478

No regional properties for P97478

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P97478

Functions

Description
EC Number 1.14.99.60 Miscellaneous
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
extrinsic component of mitochondrial inner membrane The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ubiquinone biosynthesis complex The cytosolic ubiquinone biosynthesis complex is composed of enzymes and accessory factors of the ubiquinone biosynthesis pathway and enables synthesis of the extremely hydrophobic molecule ubiquinone. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K.

4 GO annotations of molecular function

Name Definition
3-demethoxyubiquinol 3-hydroxylase activity Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
metal ion binding Binding to a metal ion.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.

14 GO annotations of biological process

Name Definition
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
in utero embryonic development The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
mitochondrial ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.
mitochondrion morphogenesis The process in which the anatomical structures of a mitochondrion are generated and organized.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
neural tube formation The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
neurogenesis Generation of cells within the nervous system.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of reactive oxygen species metabolic process Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.
respiratory electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41735 CAT5 5-demethoxyubiquinone hydroxylase, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q2TBW2 COQ7 5-demethoxyubiquinone hydroxylase, mitochondrial Bos taurus (Bovine) PR
10 20 30 40 50 60
MSAAGAIAAA SVGRLRTGVR RPFSEYGRGL IIRCHSSGMT LDNINRAAVD RIIRVDHAGE
70 80 90 100 110 120
YGANRIYAGQ MAVLGRTSVG PVIQKMWDQE KNHLKKFNEL MIAFRVRPTV LMPLWNVAGF
130 140 150 160 170 180
ALGAGTALLG KEGAMACTVA VEESIANHYN NQIRMLMEED PEKYEELLQV IKQFRDEELE
190 200 210
HHDTGLDHDA ELAPAYALLK RIIQAGCSAA IYLSERF