Q2TBW2

PR
Gene name
COQ7
Protein name
5-demethoxyubiquinone hydroxylase, mitochondrial
Names
DMQ hydroxylase, Timing protein clk-1 homolog, Ubiquinone biosynthesis monooxygenase COQ7
Species
Bos taurus (Bovine)
KEGG Pathway
bta:504771
EC number
1.14.99.60: Miscellaneous
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2TBW2

Entry ID Method Resolution Chain Position Source
AF-Q2TBW2-F1 Predicted AlphaFoldDB

No variants for Q2TBW2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q2TBW2

No associated diseases with Q2TBW2

No regional properties for Q2TBW2

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q2TBW2

Functions

Description
EC Number 1.14.99.60 Miscellaneous
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
extrinsic component of mitochondrial inner membrane The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
3-demethoxyubiquinol 3-hydroxylase activity Catalysis of the reaction: a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O.
metal ion binding Binding to a metal ion.
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor.

4 GO annotations of biological process

Name Definition
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of reactive oxygen species metabolic process Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P97478 Coq7 5-demethoxyubiquinone hydroxylase, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MSCARALAAC CLWRLRTGAL QPLSAYGRRI SVRFCSSGMT LDNINREAVD RIIRVDHAGE
70 80 90 100 110 120
YGANRIYAGQ MAVLGRTSIG PVIQKMWDQE KDHLKKFNEL MVAFRVRPTV LMPFWNVVGF
130 140 150 160 170 180
ALGAGTALLG KEGAMACTVA VEESIAHHYN NQIRTLMEKE PEKYEELLQV IKKFRDEELE
190 200 210
HHDIGLEHDA ELAPAYVVLK SVIQAGCKVA IYLSERL