P59999

PR
Gene name
Arpc4 (Arc20)
Protein name
Actin-related protein 2/3 complex subunit 4
Names
Arp2/3 complex 20 kDa subunit, p20-ARC
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:68089
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P59999

Entry ID Method Resolution Chain Position Source
7AQK EM 900 A f 1-168 PDB
AF-P59999-F1 Predicted AlphaFoldDB

8 variants for P59999

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388853432 5 L>P No EVA
rs3388814776 13 R>Q No EVA
rs3388846723 30 V>L No EVA
rs3388829156 44 K>E No EVA
rs3388840063 128 K>E No EVA
rs3388829183 138 F>I No EVA
rs3388835322 139 M>K No EVA
rs3397394865 169 F>K No EVA

No associated diseases with P59999

4 regional properties for P59999

Type Name Position InterPro Accession
domain ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain 186 - 405 IPR000194
domain AAA+ ATPase domain 198 - 382 IPR003593
domain ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain 63 - 129 IPR004100
active_site ATPase, alpha/beta subunit, nucleotide-binding domain, active site 396 - 405 IPR020003

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Cell projection
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
Arp2/3 protein complex A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

4 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
protein-macromolecule adaptor activity The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
structural constituent of cytoskeleton The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.

3 GO annotations of biological process

Name Definition
actin filament polymerization Assembly of actin filaments by the addition of actin monomers to a filament.
Arp2/3 complex-mediated actin nucleation The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.
regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q148J6 ARPC4 Actin-related protein 2/3 complex subunit 4 Bos taurus (Bovine) PR
P59998 ARPC4 Actin-related protein 2/3 complex subunit 4 Homo sapiens (Human) PR
P58798 arx-6 Probable actin-related protein 2/3 complex subunit 4 Caenorhabditis elegans PR
10 20 30 40 50 60
MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VTISRNEKEK
70 80 90 100 110 120
VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN
130 140 150 160
FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNF