P58798

PR
Gene name
arx-6 (C35D10.16)
Protein name
Probable actin-related protein 2/3 complex subunit 4
Names
Arp2/3 complex 20 kDa subunit, p20-ARC
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C35D10.16
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P58798

Entry ID Method Resolution Chain Position Source
AF-P58798-F1 Predicted AlphaFoldDB

No variants for P58798

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P58798

No associated diseases with P58798

No regional properties for P58798

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P58798

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Arp2/3 protein complex A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

5 GO annotations of biological process

Name Definition
actin filament polymerization Assembly of actin filaments by the addition of actin monomers to a filament.
Arp2/3 complex-mediated actin nucleation The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.
epithelial cell migration The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.
morphogenesis of embryonic epithelium The process in which the anatomical structures of embryonic epithelia are generated and organized.
regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q148J6 ARPC4 Actin-related protein 2/3 complex subunit 4 Bos taurus (Bovine) PR
P59998 ARPC4 Actin-related protein 2/3 complex subunit 4 Homo sapiens (Human) PR
P59999 Arpc4 Actin-related protein 2/3 complex subunit 4 Mus musculus (Mouse) PR
10 20 30 40 50 60
MSATLQPYLE AVRHTLQAAL CLEQFSSQVV ERHNKPEVEV QTSKELLMTP VVVARNKQER
70 80 90 100 110 120
VLIEPSVNSV RISIAIKQSD EIEKILCHKF TRFMCQRADN FFVLRRKPLP GYDISFLITA
130 140 150 160
SHTEAMFKHK LVDFLLHFMQ EIDKEISEMK LSLNARARVS AEEFLKRFN