P59889

PR
Gene name
slc39a1 (zip1, sb:cb629, zgc:111852)
Protein name
Zinc transporter ZIP1
Names
DrZIP1, Solute carrier family 39 member 1, Zrt- and Irt-like protein 1, ZIP-1
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:321324
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

83-178 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P59889

Entry ID Method Resolution Chain Position Source
AF-P59889-F1 Predicted AlphaFoldDB

No variants for P59889

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P59889

No associated diseases with P59889

2 regional properties for P59889

Type Name Position InterPro Accession
domain SH3 domain 283 - 344 IPR001452
domain Pleckstrin homology domain 109 - 214 IPR001849

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
zinc ion binding Binding to a zinc ion (Zn).
zinc ion transmembrane transporter activity Enables the transfer of zinc (Zn) ions from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
zinc ion transmembrane transport A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
zinc ion transport The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O81123 ZIP1 Zinc transporter 1 Arabidopsis thaliana (Mouse-ear cress) PR
O23039 ZIP5 Zinc transporter 5 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDYLLQVKVG ALVGLLLLTL FFGFIPARMK WFHVTGGTEL HKAVLSFVSC FAGGVFLSAC
70 80 90 100 110 120
LLDIIPDYLS DIHGELQKRD LDDGFPLPEF IMACGFFTVL ILEKMVLSCT EGHRNEETAP
130 140 150 160 170 180
LLAPAAPNGH AHGHPSVNDL EGSGHHVHVD FHAHSSFRSF MLFLSLSLHS VFEGLAIGLQ
190 200 210 220 230 240
TTNAKVLEIC IAILVHKSII VFSLSVKLVQ SAVKPLWVVL YVTVFAIMSP LGIGIGIVVI
250 260 270 280 290 300
ETERQAGGLI QAVLEGLAAG TFIYITFLEI LPHELNSSER PLLKVLFLLC GFSIMAALCF
LG