P59016
PR
Gene name |
Vps33b |
Protein name |
Vacuolar protein sorting-associated protein 33B |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:233405 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P59016
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P59016-F1 | Predicted | AlphaFoldDB |
21 variants for P59016
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388908903 | 42 | E>D | No | EVA | |
| rs1134520272 | 51 | R>* | No | EVA | |
| rs3388918119 | 71 | N>D | No | EVA | |
| rs3388921032 | 106 | G>D | No | EVA | |
| rs3388893392 | 115 | L>I | No | EVA | |
| rs3388879686 | 126 | V>E | No | EVA | |
| rs3388903994 | 159 | E>* | No | EVA | |
| rs3388924059 | 174 | N>D | No | EVA | |
| rs3388914958 | 221 | R>W | No | EVA | |
| rs3388924895 | 274 | S>C | No | EVA | |
| rs3388917981 | 279 | L>P | No | EVA | |
| rs3388914924 | 313 | D>Y | No | EVA | |
| rs3388912498 | 359 | D>N | No | EVA | |
| rs3388912558 | 402 | L>I | No | EVA | |
| rs3388912541 | 499 | G>E | No | EVA | |
| rs3388912507 | 502 | D>H | No | EVA | |
| rs3388908928 | 549 | F>C | No | EVA | |
| rs3397910073 | 559 | K>M | No | EVA | |
| rs3398197800 | 559 | K>Q | No | EVA | |
| rs3398000266 | 590 | E>Q | No | EVA | |
| rs3388912494 | 617 | S>F | No | EVA |
No associated diseases with P59016
No regional properties for P59016
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P59016 | |||
Functions
17 GO annotations of cellular component
| Name | Definition |
|---|---|
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
| CORVET complex | A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| HOPS complex | A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| platelet alpha granule | A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). |
| recycling endosome | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
| vesicle tethering complex | Any protein complex that plays a role in vesicle tethering. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein-containing complex binding | Binding to a macromolecular complex. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| collagen fibril organization | Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. |
| collagen metabolic process | The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). |
| endosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| lysosome localization | Any process in which a lysosome is transported to, and/or maintained in, a specific location. |
| megakaryocyte development | The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. |
| melanosome localization | Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell. |
| membrane fusion | The membrane organization process that joins two lipid bilayers to form a single membrane. |
| peptidyl-lysine hydroxylation | The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine. |
| platelet alpha granule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of platelet aggregation | Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2HJ18 | VPS33B | Vacuolar protein sorting-associated protein 33B | Bos taurus (Bovine) | PR |
| Q9H267 | VPS33B | Vacuolar protein sorting-associated protein 33B | Homo sapiens (Human) | PR |
| Q64324 | Stxbp2 | Syntaxin-binding protein 2 | Mus musculus (Mouse) | PR |
| O08599 | Stxbp1 | Syntaxin-binding protein 1 | Mus musculus (Mouse) | PR |
| Q63616 | Vps33b | Vacuolar protein sorting-associated protein 33B | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFPHRLDAP | ELPDFSMLKR | LARDQLIYLL | EQLPGKKDLF | IEADLMSPLD | RIANVSILKQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HEVDKLYKVE | NKPALSANEQ | LCFLVRPRIK | NMRYIASLVN | ADKLAGRIRK | YKVILSPQKF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YACEMVLEEE | GVYGDVSCDE | WAFSLLPLDV | DLLSMELPEF | FRDYFLEGDQ | RWINTVAQAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HLLSTLYGPF | PNCYGIGRCA | KMSYDLWRKL | EEEEDSETKG | RKPEIGHIFL | LDRDVDFVTA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LCSQVVYEGL | VDDTFRIKCG | SVDFGPEVTS | SDKSLKVLLN | AEDKVFSEIR | NEHFSNVFGF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSQKARNLQA | QYDRRRGMDI | KQMKNFVSQE | LKGLKQEHRL | LSLHIGACES | IMKKKTKQDF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QELIKTEHAL | LEGFNIREST | SYIEEHIDRQ | VSPIESLRLM | CLLSITENGL | IPKDYRSLKT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QYLQSYGPEH | LLTFSNLRRA | GLLTEQAPGD | TLTAVESKVS | KLVTDKAAGK | ITDAFSSLAK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RSNFRAISKK | LNLIPRVDGE | YDLKVPRDMA | YVFSGAYVPL | SCRIIEQVLD | RRSWQGLDEV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VRLLNCSEFA | FTDTAKEDKA | SSESLRLILV | VFLGGCTFSE | ISALRFLGRE | KGYRFIFLTT |
| 610 | |||||
| AVTNSARLME | AMSEVKS |