Q2HJ18

PR
Gene name
VPS33B
Protein name
Vacuolar protein sorting-associated protein 33B
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:526538
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

284-353 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q2HJ18

Entry ID Method Resolution Chain Position Source
AF-Q2HJ18-F1 Predicted AlphaFoldDB

163 variants for Q2HJ18

Variant ID(s) Position Change Description Diseaes Association Provenance
rs466093423 7 P>A No EVA
rs436241739 8 D>N No EVA
rs443728705 14 D>G No EVA
rs452509635 18 L>I No EVA
rs470869233 20 R>M No EVA
rs470869233 20 R>T No EVA
rs459845699 28 Y>C No EVA
rs459845699 28 Y>S No EVA
rs442280847 32 Q>P No EVA
rs471656666 63 V>G No EVA
rs468675765 178 Q>K No EVA
rs440325181 199 C>G No EVA
rs456464338 215 D>E No EVA
rs471954538 216 G>D No EVA
rs438866721 217 E>G No EVA
rs472627479 228 I>T No EVA
rs442943893 232 D>H No EVA
rs439733539 232 D>V No EVA
rs470278337 264 F>L No EVA
rs437289222 269 T>P No EVA
rs441767475 291 N>H No EVA
rs457236660 292 E>Q No EVA
rs475669805 293 H>D No EVA
rs439623954 293 H>P No EVA
rs458129019 294 F>S No EVA
rs479937425 296 N>H No EVA
rs440519164 298 F>L No EVA
rs462206552 302 S>R No EVA
rs480836037 303 Q>K No EVA
rs469707549 310 A>P No EVA
rs463977312 312 Y>* No EVA
rs445668816 312 Y>D No EVA
rs445668816 312 Y>N No EVA
rs452913389 313 D>A No EVA
rs434315847 313 D>Y No EVA
rs445006391 317 G>A No EVA
rs466907379 319 D>E No EVA
rs433858103 320 I>L No EVA
rs455754638 323 M>L No EVA
rs474227666 324 K>R No EVA
rs456580152 325 N>K No EVA
rs437966343 325 N>S No EVA
rs471874474 332 K>R No EVA
rs439003105 334 L>V No EVA
rs136476449 338 H>P No EVA
rs460577660 342 S>R No EVA
rs433349728 347 A>S No EVA
rs442642417 348 C>* No EVA
rs461129555 352 M>L No EVA
rs483026211 353 K>* No EVA
rs449984926 354 K>* No EVA
rs458649004 355 K>E No EVA
rs447555742 357 K>E No EVA
rs466143637 358 Q>H No EVA
rs436487280 360 F>C No EVA
rs448607537 360 F>L No EVA
rs470381787 361 Q>P No EVA
rs437345025 364 I>S No EVA
rs475820708 373 G>W No EVA
rs458243116 374 F>I No EVA
rs458243116 374 F>L No EVA
rs458243116 374 F>V No EVA
rs473483269 376 I>L No EVA
rs440633871 376 I>N No EVA
rs440633871 376 I>S No EVA
rs451106313 378 E>D No EVA
rs481625850 379 S>R No EVA
rs463231848 379 S>R No EVA
rs445563556 380 T>S No EVA
rs434428117 381 N>H No EVA
rs446670351 381 N>S No EVA
rs446670351 381 N>T No EVA
rs434428117 381 N>Y No EVA
rs468364443 382 Y>S No EVA
rs435347321 385 E>V No EVA
rs457176723 386 H>D No EVA
rs475659261 387 I>T No EVA
rs451718815 390 Q>R No EVA
rs455710020 392 S>* No EVA
rs433981302 392 S>A No EVA
rs438074824 403 L>F No EVA
rs467873835 403 L>S No EVA
rs456443249 405 I>S No EVA
rs437976011 425 S>G No EVA
rs440636451 427 G>V No EVA
rs455892060 428 P>S No EVA
rs474343425 430 H>N No EVA
rs444714630 434 F>L No EVA
rs463057259 436 N>T No EVA
rs439178490 439 R>P No EVA
rs457814352 441 G>W No EVA
rs446641593 445 E>G No EVA
rs468389979 448 P>T No EVA
rs480387191 451 T>P No EVA
rs450825005 452 L>V No EVA
rs469228844 453 T>P No EVA
rs451672663 455 V>G No EVA
rs467062650 457 S>I No EVA
rs434054519 457 S>R No EVA
rs455721207 459 V>E No EVA
rs455721207 459 V>G No EVA
rs474228630 460 S>R No EVA
rs438110615 461 K>T No EVA
rs471904585 463 V>G No EVA
rs1116632523 464 T>M No EVA
rs439213888 465 D>G No EVA
rs457726869 466 K>M No EVA
rs440113816 467 A>P No EVA
rs464101489 469 G>A No EVA
rs431908561 486 A>D No EVA
rs447308154 487 I>S No EVA
rs465691502 491 L>P No EVA
rs459499309 492 N>I No EVA
rs436202592 493 L>M No EVA
rs719026906 519 P>H No EVA
rs473071163 528 V>E No EVA
rs462781447 534 W>C No EVA
rs444320752 534 W>G No EVA
rs444320752 534 W>R No EVA
rs478287390 535 Q>E No EVA
rs445187723 535 Q>R No EVA
rs466930171 536 G>S No EVA
rs449261475 537 L>P No EVA
rs449261475 537 L>R No EVA
rs456860580 538 D>E No EVA
rs438117162 538 D>G No EVA
rs465621794 539 E>A No EVA
rs465621794 539 E>G No EVA
rs451175808 540 V>E No EVA
rs451175808 540 V>G No EVA
rs432794551 540 V>M No EVA
rs472954492 541 V>G No EVA
rs440151271 542 R>G No EVA
rs474004880 543 L>R No EVA
rs455378493 543 L>V No EVA
rs462906555 544 L>R No EVA
rs444184666 544 L>V No EVA
rs478134001 545 N>H No EVA
rs438822776 545 N>T No EVA
rs460393557 547 S>G No EVA
rs460393557 547 S>R No EVA
rs478786762 547 S>R No EVA
rs449306161 548 E>G No EVA
rs483276342 549 L>P No EVA
rs483276342 549 L>R No EVA
rs467695235 549 L>V No EVA
rs450177937 550 A>G No EVA
rs465710803 551 F>C No EVA
rs432691030 552 T>I No EVA
rs432691030 552 T>K No EVA
rs447993401 554 M>I No EVA
rs466461600 558 D>E No EVA
rs433610557 561 S>A No EVA
rs448881405 561 S>C No EVA
rs467527862 563 E>Q No EVA
rs437702844 564 S>P No EVA
rs432146262 571 V>G No EVA
rs449642991 593 Y>D No EVA
rs465057408 605 S>R No EVA
rs716688967 606 A>V No EVA
rs476920988 609 M>R No EVA
rs447272923 612 M>T No EVA
rs436108568 618 A>R No EVA

No associated diseases with Q2HJ18

No regional properties for Q2HJ18

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q2HJ18

Functions

Description
EC Number
Subcellular Localization
  • Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Early endosome
  • Cytoplasmic vesicle, clathrin-coated vesicle
  • Recycling endosome
  • Colocalizes in clusters with VIPAS39 at cytoplasmic organelles
  • Colocalizes with RAB11A and VIPAS39 on recycling endosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

14 GO annotations of cellular component

Name Definition
clathrin-coated vesicle A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
CORVET complex A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
early endosome membrane The lipid bilayer surrounding an early endosome.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
HOPS complex A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion.
late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
late endosome membrane The lipid bilayer surrounding a late endosome.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
platelet alpha granule A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

1 GO annotations of molecular function

Name Definition
protein-containing complex binding Binding to a macromolecular complex.

13 GO annotations of biological process

Name Definition
collagen fibril organization Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.
collagen metabolic process The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
endosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
lysosome localization Any process in which a lysosome is transported to, and/or maintained in, a specific location.
megakaryocyte development The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.
melanosome localization Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell.
membrane fusion The membrane organization process that joins two lipid bilayers to form a single membrane.
peptidyl-lysine hydroxylation The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine.
platelet alpha granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of platelet aggregation Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H267 VPS33B Vacuolar protein sorting-associated protein 33B Homo sapiens (Human) PR
P59016 Vps33b Vacuolar protein sorting-associated protein 33B Mus musculus (Mouse) PR
Q63616 Vps33b Vacuolar protein sorting-associated protein 33B Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAFPHRPDAP ELPDFSMLKR LARDQLIYLL EQLPGKKDLF IEADLMSPLD RIANVSILKQ
70 80 90 100 110 120
HEVDKLYKVE NKPALSSSEQ LCFLVRPRIK NMRYIASLVN ADKMAGRTRK YKVIFSPQKF
130 140 150 160 170 180
YACEMVLEEE GVYGDVSCDE WAFSLLPLDV DLLSMELPEF FRDYFLEGDQ RWINTLAQAL
190 200 210 220 230 240
HLLSTLYGPF PNCYGIGRCA KMSYELWKRL EEEEDGETKG RRPEIGHIFL LDRDVDFVTA
250 260 270 280 290 300
LCSQVVYEGL VDDTFRIKCG SVDFGPEVTS SDKSLKVLLN AEDKVFNEIR NEHFSNVFGF
310 320 330 340 350 360
LSQKARNLQA QYDRRRGMDI KQMKNFVSQE LKGLKQEHRL LSLHIGACES IMKKKTKQDF
370 380 390 400 410 420
QELIKTEHAL LEGFNIREST NYIEEHIDRQ VSPIESLRLM CLLSITENGL IPKDYRSLKT
430 440 450 460 470 480
QYLQSYGPEH LLTFFNLRRA GLLTEQAPGD TLTAVESKVS KLVTDKAAGK ITDAFSSLAK
490 500 510 520 530 540
RSNFRAISKK LNLIPRVDGE YDLKVPRDMA YVFSGAYVPL SCRIIEQVLE RRGWQGLDEV
550 560 570 580 590 600
VRLLNCSELA FTDMTKDDKA SSESLRLILV VFLGGCTFSE ISALRFLGRE KGYRFIFLTT
610
AVTNSARLME AMSEVKA