P57759
Gene name |
Erp29 |
Protein name |
Endoplasmic reticulum resident protein 29 |
Names |
ERp29 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67397 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P57759
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P57759-F1 | Predicted | AlphaFoldDB |
10 variants for P57759
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs253457863 | 7 | V>A | No | EVA | |
| rs3388782715 | 77 | R>H | No | EVA | |
| rs234693021 | 87 | E>D | No | EVA | |
| rs3388783074 | 94 | G>V | No | EVA | |
| rs33691089 | 135 | N>S | No | EVA | |
| rs248431512 | 179 | R>Q | No | EVA | |
| rs3388786978 | 184 | K>R | No | EVA | |
| rs13473216 | 187 | Q>L | No | EVA | |
| rs3388783155 | 233 | K>M | No | EVA | |
| rs48978392 | 256 | E>G | No | EVA |
No associated diseases with P57759
1 regional properties for P57759
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | SsrA-binding protein, conserved site | 33 - 45 | IPR020081 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum lumen | The volume enclosed by the membranes of the endoplasmic reticulum. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| smooth endoplasmic reticulum | The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. |
| transport vesicle | Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| chaperone binding | Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| endoplasmic reticulum to Golgi vesicle-mediated transport | The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| negative regulation of protein secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of MAP kinase activity | Any process that activates or increases the frequency, rate or extent of MAP kinase activity. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| protein secretion | The controlled release of proteins from a cell. |
| regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAAAGVSGA | ASLSPLLSVL | LGLLLLFAPH | GGSGLHTKGA | LPLDTVTFYK | VIPKSKFVLV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KFDTQYPYGE | KQDEFKRLAE | NSASSEELLV | AEVGISDYGD | KLNMELSEKY | KLDKESYPVF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YLFRDGDLEN | PVLYNGAVKV | GAIQRWLKGQ | GVYLGMPGCL | PAYDALAGEF | IKASSIEARQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AILKQGQDGL | LSVKETEKKW | ASQYLKIMGK | ILDQGEDFPA | SEMARIGKLI | ENKMSDSKKE |
| 250 | 260 | ||||
| ELQKSLNILT | AFRKKEAEKE | EL |