AiPD: Autoinhibited Protein Database

P30040

Gene name	ERP29 (C12orf8, ERP28)
Protein name	Endoplasmic reticulum resident protein 29
Names	ERp29, Endoplasmic reticulum resident protein 28, ERp28, Endoplasmic reticulum resident protein 31, ERp31
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10961
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-112 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-112 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for P30040

Entry ID	Method	Resolution	Chain	Position	Source
2QC7	X-ray	290 A	A/B	34-261	PDB
5V8Z	X-ray	210 A	A/C	158-261	PDB
5V90	X-ray	325 A	A/C	158-261	PDB
AF-P30040-F1	Predicted				AlphaFoldDB

223 variants for P30040

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs754475719 CA6794070	3	A>G		No	ClinGen ExAC gnomAD
rs754475719 CA386758404	3	A>V		No	ClinGen ExAC gnomAD
rs1460610600 CA386758413	4	A>G		No	ClinGen gnomAD
rs752354151 CA6794072	4	A>S		No	ClinGen ExAC gnomAD
CA386758415 rs1460610600	4	A>V		No	ClinGen gnomAD
rs1236120791 CA386758420	5	V>L		No	ClinGen gnomAD
COSM3792200 rs772553444 CA6794076	6	P>L	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs772553444 CA386758436	6	P>R		No	ClinGen ExAC TOPMed gnomAD
rs368334361 CA6794075	6	P>S		No	ClinGen ESP ExAC gnomAD
CA6794074 rs368334361	6	P>T		No	ClinGen ESP ExAC gnomAD
rs1464192555 CA386758440	7	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA386758445 rs1325791288	7	R>H		No	ClinGen TOPMed
TCGA novel	7	R>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6794079 rs369530971	8	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA6794078 rs375049550	8	A>T		No	ClinGen ESP ExAC gnomAD
CA6794080 rs141517360	9	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA6794082 rs553491906	10	F>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs553491906 CA6794083	10	F>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs762655268 CA6794084	11	L>F		No	ClinGen ExAC TOPMed gnomAD
rs751471173 CA6794086	12	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1565985855 CA386758495	12	S>T		No	ClinGen Ensembl
rs1047440176 CA243690417	13	P>S		No	ClinGen TOPMed gnomAD
CA6794087 rs759574747	14	L>Q		No	ClinGen ExAC gnomAD
CA6794088 rs767084110	15	L>I		No	ClinGen ExAC gnomAD
CA6794089 rs752231140	16	P>R		No	ClinGen ExAC TOPMed gnomAD
rs542501885 CA243690428	17	L>F		No	ClinGen 1000Genomes
CA6794091 rs763648928	17	L>P		No	ClinGen ExAC gnomAD
rs780409590 CA6794094	23	L>F		No	ClinGen ExAC gnomAD
rs367717851 CA6794096	24	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs367717851 CA6794095	24	L>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs367717851 CA243690446	24	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA243690453 rs373057753	26	A>P		No	ClinGen Ensembl
CA243690454 rs373057753	26	A>S		No	ClinGen Ensembl
CA6794097 COSM935128 rs781692469	26	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs748152416 CA386758674	28	H>P		No	ClinGen ExAC gnomAD
CA6794098 rs748152416	28	H>R		No	ClinGen ExAC gnomAD
CA6794100 rs773298381	29	G>D		No	ClinGen ExAC TOPMed gnomAD
CA386759038 rs1278227057	30	G>S		No	ClinGen gnomAD
CA386759043 rs1311479545	31	S>R		No	ClinGen TOPMed
CA6794102 rs770804673	32	G>S		No	ClinGen ExAC gnomAD
CA6794103 rs774322037	34	H>P		No	ClinGen ExAC gnomAD
CA243690477 rs886272772	34	H>Y		No	ClinGen TOPMed
rs200299339 CA243690500	36	K>E		No	ClinGen 1000Genomes gnomAD
CA386759086 rs1284011921	38	A>T		No	ClinGen gnomAD
CA386759096 rs1593720230	39	L>P		No	ClinGen Ensembl
CA6794105 rs767542071	39	L>V		No	ClinGen ExAC gnomAD
rs1003499004 CA243690508	40	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1003499004 CA386759097	40	P>T		No	ClinGen gnomAD
CA386759105 rs1362818389	41	L>P		No	ClinGen TOPMed
CA243690534 rs149494744	42	D>A		No	ClinGen ESP TOPMed gnomAD
rs137981237 CA243690519	42	D>Y		No	ClinGen ESP TOPMed gnomAD
CA6794106 rs143957874	43	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA6794107 rs1300496866	43	T>M		No	ClinGen TOPMed
rs1300496866 CA386759122	43	T>R		No	ClinGen TOPMed
CA386759130 rs1173196781	44	V>I		No	ClinGen TOPMed
rs763665909 CA6794110	46	F>Y		No	ClinGen ExAC gnomAD
CA6794139 rs756678846	56	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1461097844 CA386760415	59	K>N		No	ClinGen gnomAD
rs778187023 CA386760454	60	F>L		No	ClinGen ExAC TOPMed gnomAD
rs200676577 CA243693129	61	D>G		No	ClinGen 1000Genomes
rs1401945138 CA386760471	61	D>N		No	ClinGen TOPMed gnomAD
rs753934196 CA6794141	62	T>A		No	ClinGen ExAC gnomAD
rs1479371074 CA386760530	63	Q>*		No	ClinGen TOPMed
CA6794143 rs757471812	66	Y>H		No	ClinGen ExAC gnomAD
rs879118935 CA243693151	67	G>C		No	ClinGen TOPMed
rs879118935 CA243693145	67	G>R		No	ClinGen TOPMed
rs879118935 CA386760623	67	G>S		No	ClinGen TOPMed
CA243693159 rs996973780	69	K>Q		No	ClinGen TOPMed
CA386760722 rs1256238880	70	Q>H		No	ClinGen gnomAD
TCGA novel	70	Q>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771935142 CA6794147	71	D>Y		No	ClinGen ExAC gnomAD
rs529253196 COSM1205659 CA6794148	75	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs913695833 CA243693173	77	A>T		No	ClinGen Ensembl
CA386760870 rs1565988931	78	E>K		No	ClinGen Ensembl
CA386760920 rs200713981	80	S>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA6794150 rs200713981	80	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1183521751 CA386760913	80	S>T		No	ClinGen gnomAD
CA386760922 rs200713981	80	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs749020999 CA6794152	83	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1175321123 CA386760989	84	D>H		No	ClinGen TOPMed gnomAD
rs1175321123 CA386760986	84	D>N		No	ClinGen TOPMed gnomAD
CA386760988 rs1175321123	84	D>Y		No	ClinGen TOPMed gnomAD
CA386761000 rs1308957376	85	D>N		No	ClinGen gnomAD
CA6794154 rs772780822	88	V>M		No	ClinGen ExAC
rs1593726962 CA386761085	89	A>T		No	ClinGen Ensembl
CA243693201 rs770918866	90	E>Q		No	ClinGen Ensembl
CA386761138 rs1196346207	91	V>L		No	ClinGen gnomAD
CA6794155 rs550719981	92	G>E		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	93	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1593726971 CA386761175	93	I>V		No	ClinGen Ensembl
CA243693204 rs1007170753	94	S>A		No	ClinGen Ensembl
CA386750240 rs1365707665	96	Y>C		No	ClinGen gnomAD
CA6794185 rs751793734	96	Y>D		No	ClinGen ExAC TOPMed gnomAD
CA6794186 rs754731938	97	G>S		No	ClinGen ExAC gnomAD
rs1352771033 CA386750266	99	K>R		No	ClinGen TOPMed gnomAD
CA6794187 rs780975580	102	M>V		No	ClinGen ExAC gnomAD
rs184215050 CA6794188	103	E>K		No	ClinGen 1000Genomes ExAC
CA6794189 rs201886997	104	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1593728453 CA386750312	105	S>R		No	ClinGen Ensembl
rs1220096040 CA386750333	108	Y>C		No	ClinGen gnomAD
CA6794192 rs748785895	109	K>N		No	ClinGen ExAC TOPMed gnomAD
CA6794193 rs770417320	110	L>V		No	ClinGen ExAC gnomAD
CA386750360 rs1396035416	112	K>R		No	ClinGen gnomAD
rs769016601 CA6794196	113	E>D		No	ClinGen ExAC gnomAD
rs1439540555 CA386750368	113	E>G		No	ClinGen gnomAD
CA386750365 rs1388345466	113	E>Q		No	ClinGen TOPMed
CA6794197 rs777167354	114	S>G		No	ClinGen ExAC gnomAD
CA6794198 rs762307012	114	S>N		No	ClinGen ExAC TOPMed gnomAD
rs765817231 CA6794199	116	P>Q		No	ClinGen ExAC gnomAD
CA386750437 rs1348261147	117	V>I		No	ClinGen TOPMed gnomAD
rs763082456 CA6794201	118	F>L		No	ClinGen ExAC gnomAD
CA6794202 rs766370416	118	F>S		No	ClinGen ExAC gnomAD
rs1045932440 CA243649880	119	Y>C		No	ClinGen TOPMed
COSM1358812 rs146674309 CA6794203	120	L>F	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA386750496 rs146674309	120	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs755173279 CA243649896	122	R>G		No	ClinGen ExAC TOPMed gnomAD
CA386750537 rs1463418907	122	R>Q		No	ClinGen TOPMed
COSM430347 rs755173279 CA6794204	122	R>W	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA386750554 rs1354274865	123	D>G		No	ClinGen gnomAD
CA243649899 rs937640190	123	D>H		No	ClinGen TOPMed
rs1323038694 CA386750635	127	E>G		No	ClinGen gnomAD
rs1237250754 CA386750671	129	P>R		No	ClinGen gnomAD
CA243649931 rs1056433471	130	V>L		No	ClinGen TOPMed
CA6794206 rs752470142	137	K>N		No	ClinGen ExAC gnomAD
CA386750820 rs1411716624	138	V>A		No	ClinGen gnomAD
CA386750842 rs1165770208	141	I>M		No	ClinGen gnomAD
rs1363420587 CA386750843	142	Q>*		No	ClinGen TOPMed gnomAD
rs532086881 CA6794208	142	Q>R		No	ClinGen 1000Genomes ExAC gnomAD
rs749188876 CA6794209	143	R>C		No	ClinGen ExAC TOPMed gnomAD
rs895507250 CA243649967	143	R>H		No	ClinGen Ensembl
rs1013931699 CA243649983	144	W>C		No	ClinGen Ensembl
CA6794210 rs756736294	145	L>M		No	ClinGen ExAC gnomAD
rs149787238 CA6794211	147	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6794212 rs145773903	149	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA243650010 rs145773903	149	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA6794213 rs771592614	151	Y>H		No	ClinGen ExAC gnomAD
CA386750916 rs1398024209	153	G>S		No	ClinGen TOPMed
rs1400262815 CA386750940	154	M>T		No	ClinGen TOPMed
CA386750965 rs1228336476	155	P>L		No	ClinGen gnomAD
CA386750974 rs1281351844	156	G>A		No	ClinGen gnomAD
CA6794214 rs200774449	157	C>Y		No	ClinGen ExAC gnomAD
rs1302336697 CA386751024	159	P>L		No	ClinGen TOPMed
CA243650066 rs967675451	161	Y>H		No	ClinGen TOPMed
CA6794220 rs201620890	162	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA6794221 rs759714503	162	D>V		No	ClinGen ExAC gnomAD
rs1033170199 CA243650100	163	A>D		No	ClinGen TOPMed gnomAD
rs752987002 COSM1205660 CA6794223	163	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA6794225 rs202069025	166	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA386751135 rs1593728702	167	E>K		No	ClinGen Ensembl
CA6794226 rs753761490	169	I>F		No	ClinGen ExAC TOPMed gnomAD
CA6794228 rs201100555	171	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6794229 rs749877798	172	S>C		No	ClinGen ExAC gnomAD
rs1483124068 CA386751256	173	G>D		No	ClinGen TOPMed
CA6794231 rs34441328	175	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA243650147 rs955603932	175	E>G		No	ClinGen TOPMed
CA6794232 rs145232105	176	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs145232105 CA6794233	176	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA6794234 rs375311941	177	R>C		No	ClinGen ESP ExAC gnomAD
rs367904459 CA6794235	177	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs367904459 CA243650186	177	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs749758716 CA6794236	179	A>G		No	ClinGen ExAC
rs771308412 CA6794237	181	L>F		No	ClinGen ExAC gnomAD
CA6794238 rs147970597	182	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA243650206 rs759534955	183	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1276993419 CA386751430	186	D>G		No	ClinGen TOPMed gnomAD
rs1276993419 CA386751431	186	D>V		No	ClinGen TOPMed gnomAD
CA386751441 rs1444582830	187	N>K		No	ClinGen gnomAD
CA386751456 rs1312342367	190	S>C		No	ClinGen TOPMed
CA386751455 rs1312342367	190	S>G		No	ClinGen TOPMed
CA6794240 rs772146162	191	V>M		No	ClinGen ExAC gnomAD
rs867986030 CA243650208	195	Q>*		No	ClinGen Ensembl
rs1262523991 CA386751492	195	Q>R		No	ClinGen gnomAD
rs1196097238 CA386751525	199	A>G		No	ClinGen gnomAD
CA6794243 rs539717665	200	E>K		No	ClinGen ExAC TOPMed gnomAD
rs763836393 CA6794244	201	Q>E		No	ClinGen ExAC gnomAD
CA6794245 rs753546254	201	Q>H		No	ClinGen ExAC gnomAD
CA386751560 rs866051165	204	K>N		No	ClinGen gnomAD
CA6794247 rs765072647	206	M>L		No	ClinGen ExAC gnomAD
CA386751579 rs1318416259	207	G>E		No	ClinGen gnomAD
rs754819048	208	K>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
COSM1298921 rs200946700 CA243650282	208	K>N	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA6794249 rs370592993	210	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs757913655 CA6794250	212	Q>E		No	ClinGen ExAC gnomAD
rs1345674422 CA386751612	212	Q>R		No	ClinGen gnomAD
CA386751629 rs1235658447	214	E>D		No	ClinGen gnomAD
CA6794252 rs779720718	214	E>K		No	ClinGen ExAC TOPMed gnomAD
rs751205381 CA386751639	216	F>I		No	ClinGen ExAC TOPMed gnomAD
rs751205381 CA6794253	216	F>L		No	ClinGen ExAC TOPMed gnomAD
CA6794255 rs754704655	217	P>L		No	ClinGen ExAC gnomAD
CA6794256 rs140712353	218	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs749606802 CA6794257	221	M>V		No	ClinGen ExAC gnomAD
CA6794258 rs192249992	222	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746390284 CA6794260	223	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA386751683 rs1157844138	223	R>W		No	ClinGen gnomAD
CA386751693 rs1158594765	225	A>T		No	ClinGen TOPMed gnomAD
rs1389445913 CA386751705	226	R>S		No	ClinGen gnomAD
CA243650378 rs1056002430	228	I>F		No	ClinGen TOPMed
CA6794262 rs775580113	229	E>G		No	ClinGen ExAC TOPMed gnomAD
CA243650380 rs867013003	229	E>K		No	ClinGen TOPMed
CA6794263 CA6794264 rs747131827	230	K>N		No	ClinGen ExAC gnomAD
rs748312022 CA243650412	232	K>Q		No	ClinGen Ensembl
CA386751745 rs1373628299	233	M>V		No	ClinGen gnomAD
CA386751755 rs1355979030	234	S>G		No	ClinGen TOPMed gnomAD
rs765083552 CA6794267	236	G>E		No	ClinGen ExAC
CA6794266 rs377230317	236	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1352097022	238	K>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs772964573 CA6794268	238	K>E		No	ClinGen ExAC TOPMed gnomAD
rs367709685 CA6794271	239	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs765945493 CA6794270	239	E>G		No	ClinGen ExAC gnomAD
rs763003414 CA6794269	239	E>K		No	ClinGen ExAC gnomAD
rs754580189 CA6794272	240	E>K		No	ClinGen ExAC gnomAD
CA6794273 rs767076764	241	L>F		No	ClinGen ExAC gnomAD
rs752403892 CA6794274	244	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1014400414 CA243650463	246	N>I		No	ClinGen Ensembl
CA243650471 rs997584842	246	N>K		No	ClinGen TOPMed
rs1457450905 CA386751891	251	F>V		No	ClinGen TOPMed
rs1051778649 CA243650480	251	F>Y		No	ClinGen TOPMed gnomAD
CA6794277 rs746335215	257	E>D		No	ClinGen ExAC gnomAD
CA6794276 rs779360111	257	E>K		No	ClinGen ExAC TOPMed gnomAD
CA386752011 rs1331041379	257	E>V		No	ClinGen gnomAD
rs561392506 CA6794280	259	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs561392506 CA386752053	259	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1041395932 CA243650549	261	L>V		No	ClinGen Ensembl

No associated diseases with P30040

2 regional properties for P30040

Type	Name	Position	InterPro Accession
domain	Endoplasmic reticulum resident protein 29, C-terminal	156 - 251	IPR011679
domain	ERp29, N-terminal	33 - 155	IPR012883

Functions

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum lumen Melanosome	Identified by mass spectrometry in melanosome fractions from stage I to stage IV
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cell surface	The external part of the cell wall and/or plasma membrane.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.
melanosome	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
smooth endoplasmic reticulum	The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.
transport vesicle	Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.

2 GO annotations of molecular function

Name	Definition
chaperone binding	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
protein homodimerization activity	Binding to an identical protein to form a homodimer.

10 GO annotations of biological process

Name	Definition
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of protein secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of MAP kinase activity	Any process that activates or increases the frequency, rate or extent of MAP kinase activity.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein secretion	The controlled release of proteins from a cell.
protein unfolding	The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P57759	Erp29	Endoplasmic reticulum resident protein 29	Mus musculus (Mouse)	PR
P52555	Erp29	Endoplasmic reticulum resident protein 29	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MAAAVPRAAF	LSPLLPLLLG	FLLLSAPHGG	SGLHTKGALP	LDTVTFYKVI	PKSKFVLVKF
70	80	90	100	110	120
DTQYPYGEKQ	DEFKRLAENS	ASSDDLLVAE	VGISDYGDKL	NMELSEKYKL	DKESYPVFYL
130	140	150	160	170	180
FRDGDFENPV	PYTGAVKVGA	IQRWLKGQGV	YLGMPGCLPV	YDALAGEFIR	ASGVEARQAL
190	200	210	220	230	240
LKQGQDNLSS	VKETQKKWAE	QYLKIMGKIL	DQGEDFPASE	MTRIARLIEK	NKMSDGKKEE
250	260
LQKSLNILTA	FQKKGAEKEE	L