P56857
Gene name |
Cldn18 |
Protein name |
Claudin-18 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56492 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P56857
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P56857-F1 | Predicted | AlphaFoldDB |
14 variants for P56857
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389010647 | 7 | Q>* | No | EVA | |
| rs3389068635 | 35 | L>M | No | EVA | |
| rs3389060517 | 77 | Q>H | No | EVA | |
| rs3389042390 | 95 | L>I | No | EVA | |
| rs3389010650 | 119 | L>P | No | EVA | |
| rs3389062928 | 165 | V>M | No | EVA | |
| rs47808961 | 174 | F>L | No | EVA | |
| rs3389064899 | 232 | T>A | No | EVA | |
| rs3389053445 | 239 | R>K | No | EVA | |
| rs3389032717 | 241 | K>M | No | EVA | |
| rs247143258 | 249 | R>H | No | EVA | |
| rs3389074226 | 254 | E>K | No | EVA | |
| rs3389010673 | 257 | H>L | No | EVA | |
| rs3389010623 | 259 | T>I | No | EVA |
No associated diseases with P56857
1 regional properties for P56857
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Claudin, conserved site | 48 - 63 | IPR017974 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| bicellular tight junction | An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| bicellular tight junction assembly | The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. |
| calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules | The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| digestive tract development | The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. |
| negative regulation of bone resorption | Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. |
| negative regulation of osteoclast development | Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development. |
| negative regulation of protein localization to nucleus | Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus. |
| protein localization to nucleus | A process in which a protein transports or maintains the localization of another protein to the nucleus. |
| response to ethanol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. |
| TNFSF11-mediated signaling pathway | The series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q0VCN0 | CLDN18 | Claudin-18 | Bos taurus (Bovine) | PR |
| P56856 | CLDN18 | Claudin-18 | Homo sapiens (Human) | PR |
| O88551 | Cldn1 | Claudin-1 | Mus musculus (Mouse) | PR |
| O35054 | Cldn4 | Claudin-4 | Mus musculus (Mouse) | PR |
| Q9NGJ7 | clc-5 | Clc-like protein 5 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATTTCQVVG | LLLSLLGLAG | CIAATGMDMW | STQDLYDNPV | TAVFQYEGLW | RSCVQQSSGF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TECRPYFTIL | GLPAMLQAVR | ALMIVGIVLG | VIGILVSIFA | LKCIRIGSMD | DSAKAKMTLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGILFIISGI | CAIIGVSVFA | NMLVTNFWMS | TANMYSGMGG | MGGMVQTVQT | RYTFGAALFV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GWVAGGLTLI | GGVMMCIACR | GLTPDDSNFK | AVSYHASGQN | VAYRPGGFKA | STGFGSNTRN |
| 250 | 260 | ||||
| KKIYDGGART | EDDEQSHPTK | YDYV |