O35054
PR
Gene name |
Cldn4 |
Protein name |
Claudin-4 |
Names |
Clostridium perfringens enterotoxin receptor, CPE-R, CPE-receptor |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12740 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O35054
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O35054-F1 | Predicted | AlphaFoldDB |
12 variants for O35054
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388778860 | 4 | M>L | No | EVA | |
| rs3388797549 | 7 | Q>* | No | EVA | |
| rs219051708 | 21 | I>V | No | EVA | |
| rs3388794783 | 28 | P>L | No | EVA | |
| rs3388799687 | 52 | M>K | No | EVA | |
| rs3388799710 | 67 | Y>H | No | EVA | |
| rs3388778916 | 81 | R>* | No | EVA | |
| rs3388789058 | 122 | G>E | No | EVA | |
| rs3388794802 | 156 | Q>L | No | EVA | |
| rs3388790687 | 177 | G>E | No | EVA | |
| rs3388786416 | 194 | Y>* | No | EVA | |
| rs3388798661 | 199 | S>A | No | EVA |
No associated diseases with O35054
2 regional properties for O35054
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | UbiE/COQ5 methyltransferase, conserved site | 79 - 94 | IPR023576-1 |
| conserved_site | UbiE/COQ5 methyltransferase, conserved site | 234 - 248 | IPR023576-2 |
Functions
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| apicolateral plasma membrane | The apical end of the lateral plasma membrane of epithelial cells. |
| basal plasma membrane | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| bicellular tight junction | An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. |
| cell-cell junction | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. |
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lateral plasma membrane | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| tight junction | A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloride channel activity | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
| identical protein binding | Binding to an identical protein or proteins. |
| structural molecule activity | The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| bicellular tight junction assembly | The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. |
| calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules | The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. |
| cell adhesion | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
| circadian rhythm | Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
| establishment of skin barrier | Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability. |
| female pregnancy | The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of metallopeptidase activity | Any process that activates or increases the frequency, rate or extent of metallopeptidase activity. |
| positive regulation of wound healing | Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. |
| regulation of cell morphogenesis | Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. |
| renal absorption | A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). |
| response to progesterone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASMGLQVLG | ISLAVLGWLG | IILSCALPMW | RVTAFIGSNI | VTAQTSWEGL | WMNCVVQSTG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QMQCKMYDSM | LALPQDLQAA | RALMVISIIV | GALGMLLSVV | GGKCTNCMED | ETVKAKIMIT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AGAVFIVASM | LIMVPVSWTA | HNVIRDFYNP | MVASGQKREM | GASLYVGWAA | SGLLLLGGGL |
| 190 | 200 | ||||
| LCCSCPPRSN | DKPYSAKYSA | ARSVPASNYV |