P54812
PR
Gene name |
cdc-48.2 (C41C4.8) |
Protein name |
Transitional endoplasmic reticulum ATPase homolog 2 |
Names |
Cell division cycle-related protein 48.2, p97/CDC48 homolog 2 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_C41C4.8 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P54812
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P54812-F1 | Predicted | AlphaFoldDB |
No variants for P54812
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P54812 | |||||
No associated diseases with P54812
11 regional properties for P54812
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CDC48, N-terminal subdomain | 31 - 113 | IPR003338 |
| domain | AAA+ ATPase domain | 242 - 378 | IPR003593-1 |
| domain | AAA+ ATPase domain | 515 - 654 | IPR003593-2 |
| domain | ATPase, AAA-type, core | 246 - 375 | IPR003959-1 |
| domain | ATPase, AAA-type, core | 519 - 652 | IPR003959-2 |
| conserved_site | ATPase, AAA-type, conserved site | 346 - 364 | IPR003960-1 |
| conserved_site | ATPase, AAA-type, conserved site | 622 - 640 | IPR003960-2 |
| domain | CDC48, domain 2 | 130 - 196 | IPR004201 |
| domain | Spastin/Vps4, C-terminal | 726 - 769 | IPR015415 |
| domain | AAA ATPase, AAA+ lid domain | 398 - 439 | IPR041569-1 |
| domain | AAA ATPase, AAA+ lid domain | 674 - 716 | IPR041569-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| VCP-NPL4-UFD1 AAA ATPase complex | A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry). |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| identical protein binding | Binding to an identical protein or proteins. |
| polyubiquitin modification-dependent protein binding | Binding to a protein upon poly-ubiquitination of the target protein. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome maturation | Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling. |
| embryo development ending in birth or egg hatching | The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. |
| ER-associated misfolded protein catabolic process | The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. |
| mitotic spindle disassembly | The controlled breakdown of the spindle during a mitotic cell cycle. |
| negative regulation of protein localization to centrosome | Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to centrosome. |
| protein localization to nucleus | A process in which a protein transports or maintains the localization of another protein to the nucleus. |
| retrograde protein transport, ER to cytosol | The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8NB90 | SPATA5 | Ribosome biogenesis protein SPATA5 | Homo sapiens (Human) | PR |
| P55072 | VCP | Transitional endoplasmic reticulum ATPase | Homo sapiens (Human) | PR |
| Q01853 | Vcp | Transitional endoplasmic reticulum ATPase | Mus musculus (Mouse) | PR |
| P54811 | cdc-48.1 | Transitional endoplasmic reticulum ATPase homolog 1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASVPTQRDE | KEKKNDELAT | AILKDKKRPN | RLIIDQSDND | DNSMVMLSQA | KMDELGLFRG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DSVILKGKKR | RETVSIVLNA | DNCPNDKIKM | NKVVRNNLRS | RLGDVVSISS | AQLEYGKRVH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VLPIDDTIEG | LTGNLFDVFL | RPYFTDAYRP | VHKGDIFTVQ | AAMRTVEFKV | VETDPAPACI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VAPDTVIHYE | GDPIKREEEE | EALNEVGYDD | LGGVRKQLAQ | IKEMVELPLR | HPQLFKAIGV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KPPRGILLFG | PPGTGKTLIA | RAVANETGAF | FFLINGPEIM | SKMSGESESN | LRKAFAECEK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NSPAILFIDE | IDAIAPKREK | AHGEVEKRIV | SQLLTLMDGL | KTRAHVVVIA | ATNRPNSIDG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ALRRFGRFDR | EIDIGIPDAV | GRLEILRIHT | KNMKLGEDVD | LEQVANECHG | FVGADLASLC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SEAAIQQIRE | KMELIDLEDD | TIDAEVLNSL | AVTMENFRFA | MGKSSPSALR | EAVVETPNTT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WSDIGGLQNV | KRELQELVQY | PVEHPEKYLK | FGMQPSRGVL | FYGPPGCGKT | LLAKAIANEC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QANFISIKGP | ELLTMWFGES | EANVRDVFDK | ARAAAPCVLF | FDELDSIAKA | RGGSVGDAGG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AADRVINQVL | TEMDGMNAKK | NVFIIGATNR | PDIIDPAVLR | PGRLDQLIYI | PLPDEASRLQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IFKASLRKTP | LSADLDLNFL | AKNTVGFSGA | DLTEICQRAC | KLAIRESIER | EIRQEKERQD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| RSARGEELME | DELADPVPEI | TRAHFEEAMK | FARRSVTDND | IRKYEMFAQT | LQQSRGFGNN |
| 790 | 800 | ||||
| FKFPGEAPSA | GQPVGGNGGS | GGNDDDDLYN |